Results 101 to 110 of about 27,691 (270)

Mitochondrial Ca2+ uniporter haploinsufficiency leads to sexually dimorphic redox imbalance and metabolic remodelling in the mouse brain

The Journal of Physiology, EarlyView.
Abstract figure legend The genetic inactivation of one Mcu allele leads to sex‐specific changes in neuronal function in adult mice, that is, the firing of action potentials and the relationship between cytosolic and mitochondrial Ca2+ levels. The ability to produce NAD(P)H by stimulated neural tissue is largely preserved in male mice but delayed in ...
Jenna Gray, Girish Halemirle, Beatriz Ferrán, Hadyn Rose, Traci L. Redwine, Sophia Pham, Bo Hagy, Atul Pranay, Jennifer Giorgione, Stacy A. Hussong, Veronica Galvan, Kenneth Humphries, Holly Van Remmen, Mike Kinter, William E. Sonntag, Pankaj K. Singh, Carlos Manlio Díaz‐García   +16 more
wiley   +1 more source

Mitochondrial physiology in cardiac muscle of deer mice native to high altitude

The Journal of Physiology, EarlyView.
Abstract figure legend High‐altitude deer mice exhibited evolved changes in mitochondrial energy metabolism and reactive oxygen species (ROS) management that may support cardiac performance under cold hypoxic conditions. High‐altitude mice had increased activity of lactate dehydrogenase (LDH) in the heart, probably enhancing the capacity for lactate ...
Ranim Saleem, Samuel G. Robichaud, Simon G. Lamarre, Graham R. Scott   +3 more
wiley   +1 more source

Closing the Carbon Loop: Continuous‐Flow Synthesis of N‐Aroyl Sulfoximines via Electrochemical CO2 Reduction

ChemSusChem, Volume 19, Issue 13, 14 July 2026.
A modular continuous‐flow platform enables the Pd‐catalyzed carbonylative N‐aroylation of sulfoximines using carbon monoxide (CO) generated on demand from carbon dioxide (CO2) via solid oxide electrolysis cell (SOEC). The integration of a heterogeneous palladium catalyst and a biomass‐derived solvent provides a safe, scalable, and sustainable route to ...
Giada Moroni, Maximilian Weiss, Giulia Russo, Gloria Biscontini, Olga Lanaridi, Andreas Limbeck, Tobias Huber, Alexander Karl Opitz, Katharina Bica‐Schröder   +8 more
wiley   +1 more source

Optimization and Scaling up of the Azaindole Derivatives Synthesis

Журнал органічної та фармацевтичної хімії
In this study, an optimized method for the synthesis of azaindoles was developed and successfully scaled up to a 100 g batch. Improved yields were observed when using electron-deficient azaheterocycles and substrates bearing electron-withdrawing ...
Mykyta V. Kordubailo, Andrey A. Tolmachev   +1 more
doaj   +1 more source

Ischemia–Reperfusion Injury: Molecular Mechanisms and Therapeutic Interventions

MedComm, Volume 7, Issue 7, July 2026.
Multiorgan ischemia–reperfusion injury begins with ischemia‐induced ATP depletion and ionic imbalance, followed by reperfusion‐triggered mitochondrial ROS/RNS bursts, regulated cell death, and DAMP release. Sterile inflammation converges on endothelial–immune–coagulation crosstalk, where NETs drive immunothrombosis, no‐reflow, and remote organ injury ...
Peng An, Yi An, Mengwei Chen, Longlong Wu, Rong Wang   +4 more
wiley   +1 more source

Tucum‐do‐Cerrado (Bactris setosa Mart.) Consumption Promoted a Healthier Expansion of Adipose Tissue in High‐Fat Diet‐Induced Obesity Rats

Molecular Nutrition &Food Research, Volume 70, Issue 13, 15 July 2026.
ABSTRACT Tucum‐do‐Cerrado (Bactris setosa Mart.) is a polyphenol‐rich Brazilian fruit known to improve glucose metabolism. This study investigated its effects on brown (BAT), inguinal (iWAT), and epididymal (eWAT) adipose tissues in a diet‐induced obesity model. Rats received control (CT/TUC‐), high‐fat (HF/TUC‐), control with Tucum‐do‐Cerrado (CT/TUC+)
Marilia Hermes Cavalcanti, Amílcar Sabino Damazo, Sandra Fernandes Arruda   +2 more
wiley   +1 more source

Redox signals and oxidative stress in the control of mitochondrial protein import

Protein Science, Volume 35, Issue 7, July 2026.
Abstract Mitochondrial protein import is essential for organelle biogenesis and cellular homeostasis. It operates in an environment that is intrinsically shaped by redox chemistry. Mitochondria are major sources of reactive oxygen species (ROS), which arise as by‐products of oxidative phosphorylation. Cells therefore maintain sophisticated ROS‐handling
Lidwina Hasberg, Viktoria Katharina Lauterbach, Torsten Ochsenreiter, Jan Riemer   +3 more
wiley   +1 more source

Carbonylative synthesis and functionalization of indoles

Beilstein Journal of Organic Chemistry
Carbonylation processes have become widely recognized as a versatile, convenient, and low-cost method for the synthesis of high-value compounds. Given the great importance of heterocyclic compounds, the carbonylative approach has become increasingly ...
Alex De Salvo, Raffaella Mancuso, Xiao-Feng Wu   +2 more
doaj   +1 more source

Reactive Oxygen Species‐Induced Damage in Cryopreserved Bovine Sperm: Mitigation Strategies

Veterinary Medicine and Science, Volume 12, Issue 4, July 2026.
Cryopreservation of bovine sperm results in overproduction of ROS due to osmotic pressure variations, ice crystals and dysfunction of mitochondria, which causes lipid peroxidation, fragmentation of DNA, protein damage and ultimately decline of post‐thaw sperm quality.
Mst. Mahomudha Akhtar, Sakib Hossain, Afia Mahmuda Meem, Afiya Fairuz Lubaba, Md. Kamrul Hasan Kazal   +4 more
wiley   +1 more source

Myosin Post‐Translational Modifications Associated With Critical Illness Myopathy

Acta Physiologica, Volume 242, Issue 7, July 2026.
ABSTRACT Background Critical illness myopathy is a common and devastating consequence of critical care, causing dramatic loss of muscle mass and function in intensive care unit patients. Functional deficits often exceed the loss in muscle mass and myosin content.
Fernando Ribeiro, Bruno Di Geronimo, Nicola Cacciani, Anna Widgren, Yvette Hedström, Anselmo S. Moriscot, Peter M. Kasson, Shina C. L. Kamerlin, Jonas Bergquist, Lars Larsson   +9 more
wiley   +1 more source