European Journal of Organic Chemistry, Volume 29, Issue 14, 15 April 2026.We report a carbonylation‐homolysis process to access acyl radicals that can undergo decarboxylation or cyclization onto tethered alkenes. In both cases, ligands and additives are shown to influence the outcome to give saturated or unsaturated products, in some cases with isomerization of the initial products.
Jacob N. Hackbarth +4 more
wiley +1 more source
Oxidative Stress in Aging Human Skin
Biomolecules, 2015 Oxidative stress in skin plays a major role in the aging process. This is true for intrinsic aging and even more for extrinsic aging. Although the results are quite different in dermis and epidermis, extrinsic aging is driven to a large extent by ...
Mark Rinnerthaler +4 more
doaj +1 more source
Palladium(II)-Catalysed Aminocarbonylation of Terminal Alkynes for the Synthesis of 2-Ynamides: Addressing the Challenges of Solvents and Gas Mixtures [PDF]
, 2017 2‐Ynamides can be synthesised through Pd(II) catalysed oxidative carbonylation, utilising low catalyst loadings. A variety of alkynes and amines can be used to afford 2‐ynamides in high yields, whilst overcoming the drawbacks associated with previous ...
Brown, Clare L +4 more
core +1 more source
Synthesis of Sulfur Heterocycles by Palladium‐Catalyzed Cyclization
European Journal of Organic Chemistry, Volume 29, Issue 14, 15 April 2026.In spite of the well‐known palladium thiophilicity, sulfur‐containing acyclic substrates may efficiently undergo several different kinds of palladium‐catalyzed cyclization processes leading to highly important sulfur heterocycles in one synthetic step. Advances in this challenging and stimulating field of research are presented in this review.
Bartolo Gabriele
wiley +1 more source
The Multifaceted Legacy of Thalidomide: Chemistry and Biology Driving Modern Drug Design
ChemMedChem, Volume 21, Issue 7, 14 April 2026.Thalidomide serves as a molecular nexus linking chemistry and biology: advances in synthesis and structural understanding enable protein degradation technologies, while its immunomodulatory activity underpins anti‐inflammatory and anticancer therapies.
Konstantina Nikovia +4 more
wiley +1 more source
Synthesis of 11C-Labelled Ureas by Palladium(II)-Mediated Oxidative Carbonylation
Molecules, 2017 Positron emission tomography is an imaging technique with applications in clinical settings as well as in basic research for the study of biological processes.
Sara Roslin +5 more
doaj +1 more source
Amodiaquine-induced toxicity in isolated rat hepatocytes and the cytoprotective effects of taurine and/or N-acetyl cysteine [PDF]
, 2014 Amodiaquine is an antimalarial drug used in the prophylaxis and treatment of this disease. However, hepatotoxicity as a life-threatening adverse effect is associated with its clinical use.
Babaei, H., Eghbal, M.A., Heidari, R.
core +1 more source
FASEB BioAdvancesDiabetic retinopathy (DR) is a major complication of diabetes mellitus. Growing evidence shows that hyperglycemia causes not only microvascular damage but also retinal neural dysfunction.
Elena Morales‐Ramírez +3 more
doaj +1 more source
Effect of chronic supplementation with methylsulfonylmethane on oxidative stress following acute exercise in untrained healthy men [PDF]
Objective This study was conducted to assess the effects of chronic daily methylsulfonylmethane (MSM) supplementation on known markers of oxidative stress following acute bouts of exercise in untrained healthy young men.
Alessio +36 more
core +1 more source
New Methodologies in Transition Metal-Mediated (11C)Radiolabelling for Positron Emission Tomography
, 2011 This thesis focuses on the requirement for new methodologies to incorporate 11C into biologically active compounds for Positron Emission Tomography (PET).
Jennings, Lucy, Jennings, Lucy
core +1 more source