Results 11 to 20 of about 14,534 (309)

A Novel Strategy to Predict Carcinogenicity of Antiparasitics Based on a Combination of DNA Lesions and Bacterial Mutagenicity Tests

Frontiers in Public Health, 2017
Genotoxicity and carcinogenicity testing of pharmaceuticals prior to commercialization is requested by regulatory agencies. The bacterial mutagenicity test was considered having the highest accuracy of carcinogenic prediction.
Qianying Liu, Zhixin Lei, Feng Zhu, Awais Ihsan, Xu Wang, Zonghui Yuan, Zonghui Yuan, Zonghui Yuan   +7 more
doaj   +2 more sources

A comprehensive analysis of the animal carcinogenicity data for glyphosate from chronic exposure rodent carcinogenicity studies

Environmental Health, 2020
Since the introduction of glyphosate-tolerant genetically-modified plants, the global use of glyphosate has increased dramatically making it the most widely used pesticide on the planet. There is considerable controversy concerning the carcinogenicity of
Christopher J. Portier
doaj   +2 more sources

Organ accumulation and carcinogenicity of highly dispersed multi-walled carbon nanotubes administered intravenously in transgenic rasH2 mice [PDF]

International Journal of Nanomedicine, 2019
Atsushi Sobajima,1 Hisao Haniu,1,2 Hiroki Nomura,1 Manabu Tanaka,1 Takashi Takizawa,1 Takayuki Kamanaka,1 Kaoru Aoki,1,3 Masanori Okamoto,1 Kazushige Yoshida,1 Jun Sasaki,1 Kumiko Ajima,2 Chika Kuroda,1,2 Haruka Ishida,2 Satomi Okano,2 Katsuya Ueda,2 ...
Sobajima A, Haniu H, Nomura H, Tanaka M, Takizawa T, Kamanaka T, Aoki K, Okamoto M, Yoshida K, Sasaki J, Ajima K, Kuroda C, Ishida H, Okano S, Ueda K, Kato H, Saito N   +16 more
doaj   +2 more sources

Bacterial Reverse Mutation Test of Verbenalin

Journal of Pharmacopuncture, 2022
Objectives: Verbenalin is a compound found in herbs such as Cornus officinalis and Verbena officinalis. This study investigated whether verbenalin is safe by analyzing its mutagenicity.
Hye Jeong Shin, Yi Gun Lim, Ji Su Ha, Gabsik Yang, Tae Han Yook   +4 more
doaj   +1 more source

The Assessment of the Biocompatibility of Dental Alloys and Alloys for Dental Amalgam. Part Second

Česká Stomatologie a Praktické Zubní Lékařství, 2014
Background: The second part of the literature review on the biocompatibility of dental alloys is focused to their possible sensibilizing effects, mutagenicity and carcinogenicity and the methods of their testing.
Z. Broukal, V. Fialová, J. Novotný
doaj   +1 more source

Carcinogenicity of Biopharmaceuticals [PDF]

, 2015
This book provides an overview of the nonclinical testing strategies that are used to asses and de-risk the genotoxicity and carcinogenicity properties of human pharmaceuticals. It includes a review of relevant ICH guidelines, numerous case studies where
van der Laan, JW, Dempster, M, ter Braak, SJ, Graziano, M, Sub Pharmacoepidemiology, Siezen, CLE, Duijnhoven, R.G., Kwa, SG, Pharmacoepidemiology and Clinical Pharmacology, Jacobson-Kram, D, van den Brink, WJ, Emerenciana, A, Bellanti, F   +12 more
core   +1 more source

Degradation of Aflatoxin B₁ in Moldy Maize by Pseudomonas aeruginosa and Safety Evaluation of the Degradation Products

Foods, 2023
Aflatoxin B1 (AFB1) is the most harmful mycotoxin commonly found in food and feed. Pollution from AFB1 causes serious economic and health issues worldwide because it causes strong mutagenicity and carcinogenicity in humans and animals.
Yanhua Xu, Renyong Zhao, Chenxi Liu
doaj   +1 more source

Study on the chronic toxicity and carcinogenicity of iron-based bioabsorbable stents

Nanotechnology Reviews, 2023
Fe-based stents have been made a figure in biodegradable stents by their good mechanical capacity and biocompatibility, appropriate strength–ductility combination. Although the iron corrosion rate was not ideal, which had been optimized by iron alloy and
Shi Xiaoli, Zhang Lu, Liu Yanfen, Wang Jinyu, Zhang Gui, Qi Haiping, Zhang Wanqian, Zhang Deyuan, Wang Jin   +8 more
doaj   +1 more source

Risk assessment of di(2-ethylhexyl) phthalate in the workplace [PDF]

Environmental Health and Toxicology, 2016
Objectives A hazard assessment of di(2-ethylhexyl) phthalate (DEHP), a commonly used workplace chemical, was conducted in order to protect the occupational health of workers.
Hyeon-Yeong Kim
doaj   +1 more source

Predicting Dose-Dependent Carcinogenicity of Chemical Mixtures Using a Novel Hybrid Neural Network Framework and Mathematical Approach

Toxics, 2023
This study addresses the challenge of assessing the carcinogenic potential of hazardous chemical mixtures, such as per- and polyfluorinated substances (PFASs), which are known to contribute significantly to cancer development.
Sarita Limbu, Sivanesan Dakshanamurthy
doaj   +1 more source