Results 241 to 250 of about 235,116 (346)

AK112 (PD-1/VEGF-a bispecific antibody) combined with chemotherapy in locally advanced pancreatic cancer: a case report. [PDF]

Front Oncol
Yan J, Dong H, Wu C, Gu H, Qi Z, Chen T, Hu B, Zhou H, Long J.   +8 more
europepmc   +1 more source

Personalized Models of Biological Barriers and Their Diseases: Recent Progress with Organs‐On‐Chips

Advanced Biology, Volume 10, Issue 2, February 2026.
Buck and Bugter et al. explore the architectural diversity and physiological functions of human barrier systems and reveal how organ‐on‐chip platforms, particularly those integrating patient‐derived cells, are advancing barrier disease modeling. They highlight how emerging biological and technological advances can be used to bridge the gap between ...
Franziska Buck, Jeroen Bugter, Gizem Yorukoglu, Mina Kazemzadeh Dastjerd, Thomas E. Winkler   +4 more
wiley   +1 more source

Integrative analysis of pancreatic microbiota and metabolome in patients with pancreatic ductal adenocarcinoma. [PDF]

Sci Rep
Zhu Y, Liang X, Li F, Xu J, Chen C, Tang H, Wang Y, Li L, Xing L, Dong Y, Li Z.   +10 more
europepmc   +1 more source

The Space Within: How Architected Voids Promote Tissue Formation

Advanced Materials, Volume 38, Issue 7, 2 February 2026.
This review explores the role of void spaces in tissue engineering scaffolds and examines four key methods for introducing porosity into hydrogels at different scales. It discusses sacrificial templating, microgels, phase separation, and 3D printing, highlighting principles, advantages, and limitations. It also addresses emerging strategies integrating
Anna Puiggalí‐Jou, Isabel B. Hui, Carla Fernandez‐Rico, Marcy Zenobi‐Wong   +3 more
wiley   +1 more source

QSOX1: A Mysterious Golgi-Localized Disulfide Bond Catalyst and an Emerging Cancer Regulator. [PDF]

Cancers (Basel)
Wang S, Xiao GY, Tan X.
europepmc   +1 more source

Phase‐Separation of YAP Mediates AJUBA Super Enhancer Activation to Promote Aberrant Mitosis in Breast Cancer

Advanced Science, Volume 13, Issue 8, 9 February 2026.
YAP undergoes phase separation to activate the AJUBA super‐enhancer, driving aberrant mitosis through spindle checkpoint dysregulation in breast cancer. This study uncovers a mechanistic link between YAP condensates, super‐enhancer activation, and aneuploidy formation.
Rui Zhang, Qingwen Huang, Zhuo Chen, Weijian Meng, Hongliang Dong, Zhihong Qi, Liang Liu, Jie Shen, Daxing Xie   +8 more
wiley   +1 more source

A 5-marker immunohistochemical panel of CK17, MEP1A, PAX8, SMAD4, and CDX2 to distinguish ovarian mucinous carcinoma from metastatic pancreatic ductal adenocarcinoma. [PDF]

Histopathology
De Boeck A, Kang EY, Meagher NS, Gorringe KL, Lee CH, Minoo P, Köbel M.   +6 more
europepmc   +1 more source

Positive Feedback Loop of Histone Lactylation‐Driven HNRNPC Promotes Autophagy to Confer Pancreatic Ductal Adenocarcinoma Gemcitabine Resistance

Advanced Science, Volume 13, Issue 8, 9 February 2026.
Histone 3 lysine18 lactylation (H3K18la) drives heterogeneous nuclear ribonucleoprotein C (HNRNPC) overexpression, activating autophagy to mediate gemcitabine resistance by stabilizing TNF receptor‐associated factor 6 (TRAF6) mRNA. Concurrently, HNRNPC stabilizes aldehyde dehydrogenase 1 family member A3 (ALDH1A3) mRNA, which enhances glycolysis and ...
Xi‐Tai Huang, Jiao Chen, En‐Liang Zhu, Ming‐Jian Ma, Yang‐Yin‐Hui Yu, Ying‐Qin Zhu, Jing‐Yuan Ye, Jin‐Zhao Xie, Zi‐Yi Zhao, Xiao‐Yu Yin   +9 more
wiley   +1 more source

A Cystic Variant of Acinar Cell Carcinoma of the Pancreas with Repeated Bleeding from a Pseudoaneurysm: A Case Report. [PDF]

Surg Case Rep
Morishima K, Endo K, Sasanuma H, Sakuma Y, Fukushima N, Yamaguchi H, Sata N.   +6 more
europepmc   +1 more source

scPER: A Rigorous Computational Approach to Determine Cellular Subtypes in Tumors Aligned With Cancer Phenotypes From Total RNA Sequencing

Advanced Science, Volume 13, Issue 8, 9 February 2026.
scPER presents an adversarial‐autoencoder framework that deconvolves bulk total RNA‐seq to quantify tumor‐microenvironment cell types and uncover phenotype‐linked subclusters. Across diverse benchmarks, scPER improves accuracy over existing tools.
Bingrui Li, Xiaobo Zhou, Raghu Kalluri
wiley   +1 more source