Results 51 to 60 of about 1,572 (155)

Optimizing Growth Conditions for Digoxin Production in Digitalis lanata Ehrh

World Journal of Traditional Chinese Medicine, 2016
Objective: Digoxin is a therapeutic cardenolide widely used to treat various heart conditions such as atrial flutter, atrial fibrillation and heart failure in both Western as well as Chinese medicine. Digoxin is extracted from cultivated Digitalis lanata
Herman A. van Wietmarschen, Hansjörg Hagels, Ron Peters, Jolanda Heistek, Jan van der Greef, Mei Wang   +5 more
doaj   +1 more source

Both synergism and interaction diversity explain the mixtures of defensive monoterpenes in spruce oleoresin

Functional Ecology, Volume 39, Issue 9, Page 2539-2551, September 2025.
Read the free Plain Language Summary for this article on the Journal blog. Abstract Chemical defences, such as the monoterpenes of conifer oleoresin, frequently occur as complex blends of many components, but the selective pressures that maintain these mixtures are not yet known.
Rashaduz Zaman, Akanksha Jain, Almuth Hammerbacher, Jonathan Gershenzon, Dineshkumar Kandasamy   +4 more
wiley   +1 more source

Biosynthetic approach to combine the first steps of cardenolide formation in Saccharomyces cerevisiae

MicrobiologyOpen, 2019
A yeast expression plasmid was constructed containing a cardenolide biosynthetic module, referred to as CARD II, using the AssemblX toolkit, which enables the assembly of large DNA constructs.
Christoph Rieck, Daniel Geiger, Jennifer Munkert, Katrin Messerschmidt, Jan Petersen, Juliane Strasser, Nadine Meitinger, Wolfgang Kreis   +7 more
doaj   +1 more source

Within‐plant variation in chemical defence of Erysimum cheiranthoides does not explain Plutella xylostella feeding preference

Plant Biology, Volume 27, Issue 5, Page 861-872, August 2025.
Novel cardenolide defences co‐vary with other defences among leaves of Erysimum cheiranthoides, but while caterpillars avoid well‐defended leaves, cardenolides alone cannot explain herbivore behaviour. Abstract Plants invest a substantial fraction of their resources into defence against herbivores, with the highest levels of defence often allocated ...
K. Wang, T. Züst
wiley   +1 more source

Allamanda cathartica leaves do not contain cardioactive glycosides [PDF]

Arquivo Brasileiro de Medicina Veterinária e Zootecnia
Allamanda cathartica, a plant used in traditional medicine for different purposes, has been considered a cardiotoxic plant. However, the alleged cardiac glycoside was not further studied. Thus, the present study aimed to determine whether the leaves of A.
B.P. Santos, G.P.P. Ataíde, C.J.C. Saraiva, M.S. Teixeira, B. Soto-Blanco   +4 more
doaj   +1 more source

Transforming Growth Factor‐β Pathway: Biological Functions and Therapeutic Targets

MedComm, Volume 6, Issue 7, July 2025.
Natural compounds modulate the TGF‐β pathway, which acts as both a tumor suppressor and promoter during cancer progression. Agents such as ginsenosides, halofuginone, and EGCG influence cell proliferation, apoptosis, and angiogenesis. These bioactive molecules may complement standard therapies, highlighting the need for advanced formulations ...
Reham Hassan Mekky, Mohammed E. Abo‐El Fetoh, Safaa A. Faheem, Abdullah F. Radwan, Mariam H. Fawzy, Aya M. Mustafa, Mohamed A. Said, Daniela Calina, Javad Sharifi‐Rad, William C. Cho   +9 more
wiley   +1 more source

Cardenolides source and therapeutic effects

JKKI (Jurnal Kedokteran dan Kesehatan Indonesia), 2017
No ...
Zahia Kabouche
doaj   +1 more source

Drug discovery with an RBM20 dependent titin splice reporter identifies cardenolides as lead structures to improve cardiac filling.

PLoS ONE, 2018
Diastolic dysfunction is increasingly prevalent in our ageing society and an important contributor to heart failure. The giant protein titin could serve as a therapeutic target, as its elastic properties are a main determinant of cardiac filling in ...
Martin Liss, Michael H Radke, Jamina Eckhard, Martin Neuenschwander, Vita Dauksaite, Jens-Peter von Kries, Michael Gotthardt   +6 more
doaj   +1 more source

Arbuscular mycorrhizal fungi alter above- and below-ground chemical defense expression differentially among Asclepias species

Frontiers in Plant Science, 2013
Belowground symbionts of plants can have substantial influence on plant growth and nutrition. Recent work demonstrates that mycorrhizal fungi can affect plant resistance to herbivory and the performance of above and belowground herbivores. Although these
Rachel L Vannette, Rachel L Vannette, Mark D. Hunter, Sergio eRasmann   +3 more
doaj   +1 more source

Advancement in research of anti-cancer effects of toad venom (ChanSu) and perspectives

World Journal of Traditional Chinese Medicine, 2015
Toad venom, called as ChanSu in China, is a widely used traditional Chinese medicine (TCM) whose active components are mainly bufadienolides. ChanSu could exhibit cardiotonic, anti-microbial, anti-inflammatory and, most importantly, anti-cancer effects ...
Miao Liu, Li-Xing Feng, Li-Hong Hu, Xuan Liu, De-An Guo   +4 more
doaj   +1 more source