Results 1 to 10 of about 145,404 (307)

Circular RNA circIGF1R controls cardiac fibroblast proliferation through regulation of carbohydrate metabolism [PDF]

Scientific Reports
Excessive fibroblast proliferation and metabolic reprogramming are hallmarks of pathological cardiac remodeling, contributing significantly to impaired cardiac function. This study investigates the role of circular RNAs (circRNAs) in fibroblast metabolic
Arne Schmidt, Kevin Schmidt, Sonja Groß, Dongchao Lu, Ke Xiao, Dimyana Neufeldt, Sarah Cushman, Nele Lehmann, Sabrina Thum, Angelika Pfanne, Annette Just, Andreas Pich, Alexander Heinz, Karsten Hiller, Hannah Jill Hunkler, Wilson Lek Wen Tan, Roger Foo, Christian Bär, Thomas Thum, Mira Jung   +19 more
doaj   +2 more sources

Sulfenylation of ERK1/2: A novel mechanism for SO2-mediated inhibition of cardiac fibroblast proliferation [PDF]

Heliyon
Background: Endogenous sulfur dioxide (SO2) plays a crucial role in protecting heart from myocardial fibrosis by inhibiting the excessive growth of cardiac fibroblasts.
Mei Ge, Lulu Zhang, Junbao Du, Hongfang Jin, Boyang Lv, Yaqian Huang   +5 more
doaj   +2 more sources

Yoda1 Inhibits TGFβ-Induced Cardiac Fibroblast Activation via a BRD4-Dependent Pathway [PDF]

Cells
Fibrosis represents a pivotal pathological process in numerous diseases, characterized by excessive deposition of extracellular matrix (ECM) that disrupts normal tissue architecture and function.
Perwez Alam, Sara M. Stiens, Hunter J. Bowles, Hieu Bui, Douglas K. Bowles   +4 more
doaj   +2 more sources

Voltage-dependent anion channel 1 (VDAC1) overexpression alleviates cardiac fibroblast activation in cardiac fibrosis via regulating fatty acid metabolism

Redox Biology, 2023
Cardiac fibrosis is characterized by the excessive deposition of extracellular matrix in the myocardium with cardiac fibroblast activation, leading to chronic cardiac remodeling and dysfunction.
Geer Tian, Junteng Zhou, Yue Quan, Qihang Kong, Junli Li, Yanguo Xin, Wenchao Wu, Xiaoqiang Tang, Xiaojing Liu   +8 more
doaj   +1 more source

Cardiac Fibroblasts and Myocardial Regeneration [PDF]

Frontiers in Bioengineering and Biotechnology, 2021
The billions of cardiomyocytes lost to acute myocardial infarction (MI) cannot be replaced by the limited regenerative capacity of adult mammalian hearts, and despite decades of research, there are still no clinically effective therapies for remuscularizing and restoring damaged myocardial tissue.
Wangping Chen, Wangping Chen, Weihua Bian, Yang Zhou, Jianyi Zhang   +4 more
openaire   +3 more sources

WTAP boosts lipid oxidation and induces diabetic cardiac fibrosis by enhancing AR methylation

iScience, 2023
Summary: Dysregulated lipid metabolism occurs in pathological processes characterized by cell proliferation and migration. Nonetheless, the mechanism of increased mitochondrial lipid oxidation is poorly appreciated in diabetic cardiac fibrosis, which is ...
Kai Song, He Sun, Bin Tu, Yang Zhou, Li-Chan Lin, Zhi-Yan Liu, Rui Li, Jing-Jing Yang, Ye Zhang, Jian-Yuan Zhao, Hui Tao   +10 more
doaj   +1 more source

Mechanism of fibroblast growth factor 21 in cardiac remodeling

Frontiers in Cardiovascular Medicine, 2023
Cardiac remodeling is a basic pathological process that enables the progression of multiple cardiac diseases to heart failure. Fibroblast growth factor 21 is considered a regulator in maintaining energy homeostasis and shows a positive role in preventing
Zeyu Zhao, Xuemei Cui, Zhangping Liao
doaj   +1 more source

Cardiac Fibroblast [PDF]

Circulation Research, 2009
The permanent cellular constituents of the heart include cardiac fibroblasts, myocytes, endothelial cells, and vascular smooth muscle cells. Previous studies have demonstrated that there are undulating changes in cardiac cell populations during embryonic development, through neonatal development and into the adult.
Colby A, Souders, Stephanie L K, Bowers, Troy A, Baudino   +2 more
openaire   +2 more sources

Cardiac Fibrosis and Fibroblasts [PDF]

Cells, 2021
Cardiac fibrosis is the excess deposition of extracellular matrix (ECM), such as collagen. Myofibroblasts are major players in the production of collagen, and are differentiated primarily from resident fibroblasts. Collagen can compensate for the dead cells produced by injury.
openaire   +3 more sources

METTL3 boosts mitochondrial fission and induces cardiac fibrosis by enhancing LncRNA GAS5 methylation

Pharmacological Research, 2023
Dysregulated mitochondrial metabolism occurs in several pathological processes characterized by cell proliferation and migration. Nonetheless, the role of mitochondrial fission is not well appreciated in cardiac fibrosis, which is accompanied by enhanced
Bin Tu, Kai Song, Yang Zhou, He Sun, Zhi-Yan Liu, Li-Chan Lin, Ji-Fei Ding, Ji-Ming Sha, Yan Shi, Jing-Jing Yang, Rui Li, Ye Zhang, Jian-Yuan Zhao, Hui Tao   +13 more
doaj   +1 more source