Results 11 to 20 of about 145,404 (307)
CARFMAP: A Curated Pathway Map of Cardiac Fibroblasts. [PDF]
PLoS ONE, 2015 The adult mammalian heart contains multiple cell types that work in unison under tightly regulated conditions to maintain homeostasis. Cardiac fibroblasts are a significant and unique population of non-muscle cells in the heart that have recently gained ...
Hieu T Nim +5 more
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Origins of Cardiac Fibroblasts [PDF]
Circulation Research, 2010 Cardiac fibroblasts play a critical role in maintenance of normal cardiac function. They are indispensable for damage control and tissue remodeling on myocardial injury and principal mediators of pathological cardiac remodeling and fibrosis. Despite their manyfold functions, cardiac fibroblasts remain poorly characterized in molecular terms.
Zeisberg, Elisabeth M., Kalluri, Raghu
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Direct Cardiac Reprogramming: Progress and Promise. [PDF]
, 2018 The human adult heart lacks a robust endogenous repair mechanism to fully restore cardiac function after insult; thus, the ability to regenerate and repair the injured myocardium remains a top priority in treating heart failure.
Ardehali, Reza, Engel, James L
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Origins of cardiac fibroblasts [PDF]
Journal of Molecular and Cellular Cardiology, 2016 Cardiac fibroblasts produce the extracellular matrix (ECM) scaffold within which the various cellular components of the heart are organized. As well as providing structural support, it is becoming evident that the quality and quantity of ECM is a key factor for determining cardiac cell behavior during development and in pathological contexts such as ...
Moore-Morris T. +3 more
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Cardiac Fibrosis and Cardiac Fibroblast Lineage-Tracing: Recent Advances
Frontiers in Physiology, 2020 Cardiac fibrosis is a common pathological change associated with cardiac injuries and diseases. Even though the accumulation of collagens and other extracellular matrix (ECM) proteins may have some protective effects in certain situations, prolonged ...
Xing Fu +4 more
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Journal of Extracellular Biology, 2023 Pathological reprogramming of cardiomyocyte and fibroblast proteome landscapes drive the initiation and progression of cardiac fibrosis. Although the secretome of dysfunctional cardiomyocytes is emerging as an important driver of pathological fibroblast ...
Bethany Claridge +5 more
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Frontiers in Cardiovascular Medicine, 2021 Evidence suggests the existence of an intracardiac dopaminergic system that plays a pivotal role in regulating cardiac function and fibrosis through G-protein coupled receptors, particularly mediated by dopamine receptor 3 (D3R).
Andrew Kisling +9 more
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Herzschrittmachertherapie + Elektrophysiologie, 2018 Fibrotic areas in cardiac muscle-be it in ventricular or atrial tissue-are considered as obstacles for conduction of the excitatory wave and can therefore facilitate re-entry, which may contribute to the sustenance of cardiac arrhythmias. Persistence of one of the most frequent arrhythmias, atrial fibrillation (AF), is accompanied by enhanced atrial ...
Klesen, Alexander +5 more
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Toll-like receptor 9 mediated responses in cardiac fibroblasts. [PDF]
PLoS ONE, 2014 Altered cardiac Toll-like receptor 9 (TLR9) signaling is important in several experimental cardiovascular disorders. These studies have predominantly focused on cardiac myocytes or the heart as a whole.
Ingrid Kristine Ohm +9 more
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JCI Insight, 2021 Cardiac inflammation and fibrosis contribute significantly to hypertension-related adverse cardiac remodeling. IκB kinase β (IKK-β), a central coordinator of inflammation through activation of NF-κB, has been demonstrated as a key molecular link between ...
Weiwei Lu +3 more
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