Results 21 to 30 of about 145,404 (307)

Regulation of Cardiac Fibroblast GLS1 Expression by Scleraxis

Cells, 2022
Fibrosis is an energy-intensive process requiring the activation of fibroblasts to myofibroblasts, resulting in the increased synthesis of extracellular matrix proteins.
Sikta Chattopadhyaya, Raghu S. Nagalingam, D. Allison Ledingham, Teri L. Moffatt, Danah S. Al-Hattab, Pavit Narhan, Matthew T. Stecy, Kimberley A. O’Hara, Michael P. Czubryt   +8 more
doaj   +1 more source

Long noncoding RNA Cfast regulates cardiac fibrosis

Molecular Therapy: Nucleic Acids, 2021
Cardiac fibrosis occurs in most cardiac diseases, which reduces cardiac muscle compliance, impairs both systolic and diastolic heart function and, ultimately, leads to heart failure.
Feng Zhang, Xuyang Fu, Masaharu Kataoka, Ning Liu, Yingchao Wang, Feng Gao, Tian Liang, Xiaoxuan Dong, Jianqiu Pei, Xiaoyun Hu, Wei Zhu, Hong Yu, Douglas B. Cowan, Xinyang Hu, Zhan-Peng Huang, Jian’an Wang, Da-Zhi Wang, Jinghai Chen   +17 more
doaj   +1 more source

Novel Techniques Targeting Fibroblasts after Ischemic Heart Injury

Cells, 2022
The great plasticity of cardiac fibroblasts allows them to respond quickly to myocardial injury and to contribute to the subsequent cardiac remodeling.
Sirin N. Cakir, Kaitlin M. Whitehead, Hanifah K. L. Hendricks, Lisandra E. de Castro Brás   +3 more
doaj   +1 more source

Complex Relationship Between Cardiac Fibroblasts and Cardiomyocytes in Health and Disease

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2021
Cardiac fibroblasts are the primary cell type responsible for deposition of extracellular matrix in the heart, providing support to the contracting myocardium and contributing to a myriad of physiological signaling processes.
Caitlin Hall, Katja Gehmlich, Chris Denning, Davor Pavlovic   +3 more
doaj   +1 more source

Cardiac fibroblast-specific p38α MAP kinase promotes cardiac hypertrophy via a putative paracrine interleukin-6 signaling mechanism [PDF]

, 2018
Recent studies suggest that cardiac fibroblast-specific p38α MAPK contributes to the development of cardiac hypertrophy, but the underlying mechanism is unknown.
Ainscough, JFX, Bageghni, SA, Denton, CP, Drinkhill, MJ, Hemmings, KE, Porter, KE, Turner, NA, Zava, N   +7 more
core   +1 more source

Cardiac Cell Patterning on Customized Microelectrode Arrays for Electrophysiological Recordings

Micromachines, 2021
Cardiomyocytes (CMs) and fibroblast cells are two essential elements for cardiac tissue structure and function. The interactions between them can alter cardiac electrophysiology and thus contribute to cardiac diseases, such as arrhythmogenesis.
Jiaying Ji, Xiang Ren, Pinar Zorlutuna
doaj   +1 more source

Comparison of Non-human Primate versus Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes for Treatment of Myocardial Infarction. [PDF]

, 2018
Non-human primates (NHPs) can serve as a human-like model to study cell therapy using induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs). However, whether the efficacy of NHP and human iPSC-CMs is mechanistically similar remains unknown.
Aguirre, Aitor, Chen, Haodong, Chour, Tony, Holmström, Alexandra, Itzhaki, Ilanit, Jain, Mohit, Kim, Youngkyun, Lehmann, Kim, Ndoye, Babacar C, Neofytou, Evgenios, Qin, Xulei, Shukla, Praveen, Wu, Joseph C, Xiao, Dan, Yang, Huaxiao, Zhang, Joe Z, Zhao, Mingtao, Zhao, Xin, Zhuge, Yan, Zimmermann, Wolfram-Hubertus   +19 more
core   +3 more sources

Cardiac fibroblast heat shock protein 47 aggravates cardiac fibrosis post myocardial ischemia–reperfusion injury by encouraging ubiquitin specific peptidase 10 dependent Smad4 deubiquitination

Acta Pharmaceutica Sinica B, 2022
Despite complications were significantly reduced due to the popularity of percutaneous coronary intervention (PCI) in clinical trials, reperfusion injury and chronic cardiac remodeling significantly contribute to poor prognosis and rehabilitation in AMI ...
Saiyang Xie, Yun Xing, Wenke Shi, Min Zhang, Mengya Chen, Wenxi Fang, Shiqiang Liu, Tong Zhang, Xiaofeng Zeng, Si Chen, Shasha Wang, Wei Deng, Qizhu Tang   +12 more
doaj   +1 more source

Confocal laser scanning microscope, raman microscopy and western blotting to evaluate inflammatory response after myocardial infarction [PDF]

, 2015
Cardiac muscle necrosis is associated with inflammatory cascade that clears the infarct from dead cells and matrix debris, and then replaces the damaged tissue with scar, through three overlapping phases: the inflammatory phase, the proliferative phase
Cantatore, S, De Carlo, D, Fineschi, Vittorio, Fiore, C, Neri, M, Riezzo, I, Turillazzi, E   +6 more
core   +1 more source

The long noncoding RNA Wisper controls cardiac fibrosis and remodeling [PDF]

, 2017
Long noncoding RNAs (lncRNAs) are emerging as powerful regulators of cardiac development and disease. However, our understanding of the importance of these molecules in cardiac fibrosis is limited. Using an integrated genomic screen, we identified Wisper
Abraham, Brian J., Alexanian, Michael, González, Arantxa, Maison, Damien, Maric, Daniel, Micheletti, Rudi, Nemir, Mohamed, Ounzain, Samir, Pedrazzini, Thierry, Plaisance, Isabelle, Sarre, Alexandre, Schroen, Blanche, Ting, Ching-Chia, Young, Richard A   +13 more
core   +2 more sources