Results 91 to 100 of about 182,384 (307)

Cardiac‐Derived ECM Microspheres for Enhanced hiPSC‐CMs Maturation

Advanced Functional Materials, EarlyView.
Cardiac extracellular matrix microspheres derived from decellularized porcine heart provide a biomimetic 3D microenvironment for human induced pluripotent stem cell–derived cardiomyocytes (hiPSC‐CMs). This platform supports short‐ and long‐term culture, enhances structural organization, and promotes electrophysiological and functional maturation of ...
Jiazhu Xu, Joel Aboagye, Marcella Edwards, Nick Rogozinski, Yufeng Wen, Angello Huerta Gomez, Zui Pan, Ge Zhang, Huaxiao Yang, Yi Hong   +9 more
wiley   +1 more source

STAT1/3 and ERK1/2 Synergistically Regulate Cardiac Fibrosis Induced by High Glucose

Cellular Physiology and Biochemistry, 2013
Background: Hyperglycaemia promotes the proliferation of cardiac fibroblasts (CFs) and collagen synthesis in CFs. However, the molecular mechanism underlying the effects of HG on proliferation and collagen synthesis of CF, is not completely understood ...
Bin Dai, Meng Cui, Mei Zhu, Wen-Ling Su, Ming-Cai Qiu, Hong Zhang   +5 more
doaj   +1 more source

Nanodiamond‐Based Quantum Sensing Reveals Changes in Endo‐Lysosomal Activity of Stimulated Cardiac Fibroblasts in a Cellular Fibrosis Model

Advanced Functional Materials, EarlyView.
Quantum sensing reveals intricate patterns linking endo‐lysosomal maturation to cardiac fibrosis progression, highlighting complexity in cellular remodeling. This study investigates fibroblast‐to‐myofibroblast transition under cell aging, stiffness, and TGF‐β stimulation, comparing nanodiamond uptake, endo‐lysosomal dynamics, and free radical ...
Aldona Mzyk, Ezgi Yilmaz, Giovanni D Angelo, Kirstine Berg‐Sørensen   +3 more
wiley   +1 more source

Characterization of multiple ion channels in cultured human cardiac fibroblasts. [PDF]

PLoS ONE, 2009
BACKGROUND: Although fibroblast-to-myocyte electrical coupling is experimentally suggested, electrophysiology of cardiac fibroblasts is not as well established as contractile cardiac myocytes.
Gui-Rong Li, Hai-Ying Sun, Jing-Bo Chen, Yuan Zhou, Hung-Fat Tse, Chu-Pak Lau   +5 more
doaj   +1 more source

Mechanically Stable and Tunable Photoactivated Peptide‐Based Hydrogels for Soft Tissue Adhesion

Advanced Functional Materials, EarlyView.
A collagen‐like peptide hydrogel platform is developed using supramolecular self‐assembly and light‐triggered crosslinking. It creates mechanically stable, tunable hydrogels with cytocompatibility and biodegradability, making them potential soft tissue adhesives.
Alex Ross, Daniel Nguyen, Aidan J. MacAdam, German A. Mercado Salazar, Micaela Gianetti, Ramis Ileri, Marc Ruel, Erik J. Suuronen, Emilio I. Alarcon   +8 more
wiley   +1 more source

Fibroblasts in the Infarcted, Remodeling, and Failing Heart

JACC: Basic to Translational Science, 2019
Summary: Expansion and activation of fibroblasts following cardiac injury is important for repair but may also contribute to fibrosis, remodeling, and dysfunction.
Claudio Humeres, PhD, Nikolaos G. Frangogiannis, MD   +1 more
doaj   +1 more source

Cardiac Fibrosis and Cardiac Fibroblast Lineage-Tracing: Recent Advances

Frontiers in Physiology, 2020
Cardiac fibrosis is a common pathological change associated with cardiac injuries and diseases. Even though the accumulation of collagens and other extracellular matrix (ECM) proteins may have some protective effects in certain situations, prolonged ...
Xing Fu, Qianglin Liu, Chaoyang Li, Yuxia Li, Leshan Wang   +4 more
doaj   +1 more source

IL-1β-mediated adaptive reprogramming of endogenous human cardiac fibroblasts to cells with immune features during fibrotic remodeling

Communications Biology, 2023
The source and roles of fibroblasts and T-cells during maladaptive remodeling and myocardial fibrosis in the setting of pulmonary arterial hypertension (PAH) have been long debated.
Jamila H. Siamwala, Francesco S. Pagano, Patrycja M. Dubielecka, Malina J. Ivey, Jose Pedro Guirao-Abad, Alexander Zhao, Sonja Chen, Haley Granston, Jae Yun Jeong, Sharon Rounds, Onur Kanisicak, Sakthivel Sadayappan, Richard J. Gilbert   +12 more
doaj   +1 more source

Effect of myocyte-fibroblast coupling on the onset of pathological dynamics in a model of ventricular tissue [PDF]

, 2017
Managing lethal cardiac arrhythmias is one of the biggest challenges in modern cardiology, and hence it is very important to understand the factors underlying such arrhythmias.
Panfilov, Alexander, Sridhar, S, Vandersickel, Nele   +2 more
core   +2 more sources

Cardiac Fibrosis [PDF]

Circulation Research, 2016
Myocardial fibrosis is a significant global health problem associated with nearly all forms of heart disease. Cardiac fibroblasts comprise an essential cell type in the heart that is responsible for the homeostasis of the extracellular matrix; however, upon injury, these cells transform to a myofibroblast phenotype and contribute to cardiac fibrosis ...
Joshua G, Travers, Fadia A, Kamal, Jeffrey, Robbins, Katherine E, Yutzey, Burns C, Blaxall   +4 more
openaire   +2 more sources