Results 11 to 20 of about 28,716 (215)
Enhanced genome editing in human iPSCs with CRISPR-CAS9 by co-targeting ATP1a1 [PDF]
PeerJ, 2020 Genome editing in human induced pluripotent stem cells (iPSCs) provides the potential for disease modeling and cell therapy. By generating iPSCs with specific mutations, researchers can differentiate the modified cells to their lineage of interest for ...
Jui-Tung Liu +3 more
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Pharmacological aspects of acute treatment glycoside intoxication
Вестник медицинского института «Реавиз»: Реабилитация, врач и здоровье, 2021 Despite the active introduction of surgical treatments for cardiac pathology and new synthetic cardiotonic drugs, cardiac glycosides (CG) remain an important component of the pharmacological treatment of heart diseases.
M. I. Sperling +2 more
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Cardiac Glycosides and Cardiomyopathy [PDF]
Hypertension, 2006 Digitalis-like steroids and related agents have been a mainstay in the treatment of congestive heart failure ever since the publication, in 1785, of Withering’s seminal monograph on foxglove. Heart failure refers to the clinical syndrome that results when the heart is unable to pump sufficient blood to keep up with the metabolic demands of the body ...
MANUNTA , PAOLO, FERRANDI M.
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Molecular Modes of Action of an Aqueous Nerium oleander Extract in Cancer Cells In Vitro and In Vivo
Molecules, 2023 Cancer drug resistance remains a major obstacle in clinical oncology. As most anticancer drugs are of natural origin, we investigated the anticancer potential of a standardized cold-water leaf extract from Nerium oleander L., termed Breastin.
Luay J. Rashan +9 more
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Activated charcoal hemadsorption in Cerbera odollam poisoning
Apollo Medicine, 2022 Cerbera odollam belongs to the poisonous Apocynaceae family, which grows in coastal salt swamps, creeks and along river banks found in South India. The poisonous part of the plant is the kernel containing the toxin cerberin which is a cardiac glycoside ...
Dyna Jones +3 more
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Onderstepoort Journal of Veterinary Research, 2005 Poisoning with cardiac glycoside-containing plants is collectively the most important plant-associated poisoning of livestock in southern Africa. As a diagnosis of this significant poisoning is currently based on circumstantial evidence, a practical ...
R.A. Schultz +2 more
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Cells, 2023 The synergy between Na+-K+ pumps, Na+-Ca2+ exchangers, membrane currents and the sarcoplasmic reticulum (SR) generates the coupled-clock system, which governs the spontaneous electrical activity of heart sinoatrial node cells (SANCs).
Sofia Segal, Yael Yaniv
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CaMKII-dependent regulation of cardiac Na(+) homeostasis. [PDF]
, 2014 Na(+) homeostasis is a key regulator of cardiac excitation and contraction. The cardiac voltage-gated Na(+) channel, NaV1.5, critically controls cell excitability, and altered channel gating has been implicated in both inherited and acquired arrhythmias.
Grandi, Eleonora, Herren, Anthony W
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Bidirectional ventricular tachycardia in cardiac sarcoidosis. [PDF]
, 2016 A 73-year-old man with history of pulmonary sarcoidosis was found to have runs of non-sustained bidirectional ventricular tachycardia (BVT) with two different QRS morphologies on a Holter monitor.
Benjamin, Mina M +4 more
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Characterisation of the Na, K pump current in atrial cells from patients with and without chronic atrial fibrillation [PDF]
, 2003 <b>Objective:</b> To assess the contribution of the Na, K pump current (<i>I</i><sub>p</sub>) to the action potential duration (APD) and effective refractory period (ERP) in human atrial cells, and to investigate ...
Kane, K.A., Rankin, A.C., Workman, A.J.
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