Results 81 to 90 of about 28,716 (215)

Inhibiting Na+/K+ ATPase can impair mitochondrial energetics and induce abnormal Ca2+ cycling and automaticity in guinea pig cardiomyocytes.

PLoS ONE, 2014
Cardiac glycosides have been used for the treatment of heart failure because of their capabilities of inhibiting Na+/K+ ATPase (NKA), which raises [Na+]i and attenuates Ca2+ extrusion via the Na+/Ca2+ exchanger (NCX), causing [Ca2+]i elevation.
Qince Li, Steven M Pogwizd, Sumanth D Prabhu, Lufang Zhou   +3 more
doaj   +1 more source

Anti‐Inflammatory, Antioxidant, Molecular Docking and Pharmacokinetics Properties of Cycloeucalenone Isolated From Musa × paradisiaca L. Fruit Peels

Chemistry &Biodiversity, Volume 23, Issue 1, January 2026.
ABSTRACT This study isolated a compound with anti‐inflammatory properties from Musa × paradisiaca fruit peels. The methanol extract was partitioned, and the hexane fraction with the best bioactivity was subjected to column chromatography before characterization via Fourier transform infrared (FTIR), UV–visible (UV–VIS) and NMR analysis.
Ibeabuchi J. Ali, Kolawole A. Olofinsan, Goodnews O. Ikeh, Ndidiamaka H. Okorie, Cyril C. Adonu, Romanus C. Omeh, Blessing C. Idoko, Pamela E. Nnamani   +7 more
wiley   +1 more source

Allamanda cathartica leaves do not contain cardioactive glycosides [PDF]

Arquivo Brasileiro de Medicina Veterinária e Zootecnia
Allamanda cathartica, a plant used in traditional medicine for different purposes, has been considered a cardiotoxic plant. However, the alleged cardiac glycoside was not further studied. Thus, the present study aimed to determine whether the leaves of A.
B.P. Santos, G.P.P. Ataíde, C.J.C. Saraiva, M.S. Teixeira, B. Soto-Blanco   +4 more
doaj   +1 more source

Evaluating the cancer therapeutic potential of cardiac glycosides [PDF]

, 2014
Cardiac glycosides, also known as cardiotonic steroids, are a group of natural products that share a steroid-like structure with an unsaturated lactone ring and the ability to induce cardiotonic effects mediated by a selective inhibition of the Na(+)/K(+)
Burgos Morón, Estefanía, Calderón Montaño, José Manuel, García Domínguez, Irene, López Lázaro, Miguel, Maldonado Navas, Dolores, Orta Vázquez, Manuel Luis   +5 more
core   +3 more sources

Exploring the Chemical Fingerprint and In Vitro Biocompatibility of Wild‐Growing and Ex Situ Cultivated Stachys cretica subsp. cretica in the Same Region (Crete, Greece)

Chemistry &Biodiversity, Volume 23, Issue 1, January 2026.
Methanol extracts and infusions of wild and cultivated Stachys cretica subsp. cretica share similar profiles. ABSTRACT The genus Stachys (Lamiaceae) comprises numerous species recognized for their ethnopharmacological importance and rich chemical profiles. In this study, we investigated the chemical composition and biocompatibility of both wild‐growing
Ekaterina‐Michaela Tomou, Maria Anagnostou, Francesco Cesare Battisti, Anastasia Karioti, Nikos Krigas, Nefeli Lagopati, Helen Skaltsa   +6 more
wiley   +1 more source

A New Cytotoxic Pregnanone from Calotropis gigantea

Molecules, 2008
A new pregnanone, named calotropone (1), was isolated from the EtOH extract of the roots of Calotropis gigantea L. together with a known cardiac glycoside. The structures were elucidated by a study of their physical and spectral data.
Mao-Yuan Wang, Zhu-Nian Wang, Wen-Li Mei, Zhuang Han, Hao-Fu Dai   +4 more
doaj   +1 more source

Exploring the anticancer mechanism of cardiac glycosides using proteome integral solubility alteration approach

Cancer Medicine
Background and Aims Cardiac glycosides (CGs), traditionally used for heart failure, have shown potential as anti‐cancer agents. This study aims to explore their multifaceted mechanisms in cancer cell biology using proteome integral solubility alteration (
Wenjie Qin, Yinhua Deng, Huan Ren, Yanling Liu, Ling Liu, Wenhui Liu, Yuxi Zhao, Chen Li, Zhiling Yang   +8 more
doaj   +1 more source

Total Synthesis of Cardenolides Acospectoside A and Acovenoside B

Molecules
Acospectoside A (1) and acovenoside B (2), two cytotoxic cardenolides extracted from the venomous South African bush Acokanthera oppositifolia, are distinguished by their unique structural motifs of the l-acovenose moiety at C-3 and a 1β-O-acetylated ...
Benzhang Liu, Peng Xu, Biao Yu
doaj   +1 more source

Preliminary qualitative screening for cancer chemopreventive agents in Telfairia occidentalis Hook.f., Gnetum africanum Welw., Gongronema latifolium Benth. and Ocimum gratissimum L. from Nigeria [PDF]

, 2009
The leaves of four plant foods commonly consumed in Nigeria namely Gnetum africanum (Igbo name: Ukazi), Gongronema latifolium (Igbo name: Utazi), Telfairia occidentalis (Igbo name: Ugu), Ocimum gratissimum (Igbo name: Nchoanwu), were each screened for ...
Iweala, E. E. J.
core  

Two preclinical tests to evaluate anticancer activity and to help validate drug candidates for clinical trials. [PDF]

, 2015
Current approaches to assessing preclinical anticancer activity do not reliably predict drug efficacy in cancer patients. Most of the compounds that show remarkable anticancer effects in preclinical models actually fail when tested in clinical trials. We
López Lázaro, Miguel
core   +2 more sources