Results 91 to 100 of about 160,558 (349)

Micromanaging cardiac regeneration: Targeted delivery of microRNAs for cardiac repair and regeneration

World Journal of Cardiology, 2016
The loss of cardiomyocytes during injury and disease can result in heart failure and sudden death, while the adult heart has a limited capacity for endogenous regeneration and repair. Current stem cell-based regenerative medicine approaches modestly improve cardiomyocyte survival, but offer neglectable cardiomyogenesis.
Kamps, Jan A.A.M., Krenning, Guido
openaire   +2 more sources

An Ionic Gelation Powder for Ultrafast Hemostasis and Accelerated Wound Healing

Advanced Functional Materials, EarlyView.
An ultrafast ionic gelation‐activated hemostatic powder (AGCL) forms a hydrogel within ≈1 s upon contact with blood‐derived calcium ions. The AGCL powder enables rapid hemorrhage control, strong tissue adhesion, and enhanced healing. The powder's pre‐crosslinked polymer network ensures high blood uptake and stability, offering effective treatment for ...
Youngju Son, Kyusoon Pak, Taehoon Lee, Monica Celine Prayogo, Jinyoung Choi, Sukkyung Kang, Minjoo Kang, Byungkook Oh, Sang Yu Sun, Sanha Kim, Sung Gap Im, Sangyong Jon, Steve Park   +12 more
wiley   +1 more source

Safety and efficacy of direct cardiac shockwave therapy in patients with ischemic cardiomyopathy undergoing coronary artery bypass grafting (the CAST-HF trial): study protocol for a randomized controlled trial—an update

Trials, 2022
Background Coronary artery disease (CAD) remains a severe socio-economic burden in the Western world. Coronary obstruction and subsequent myocardial ischemia result in the progressive replacement of contractile myocardium with dysfunctional, fibrotic ...
Felix Nägele, Leo Pölzl, Michael Graber, Jakob Hirsch, Agnes Mayr, Mathias Pamminger, Felix Troger, Markus Theurl, Michael Schreinlechner, Nikolay Sappler, Christian Dorfmüller, Martina Mitrovic, Hanno Ulmer, Michael Grimm, Can Gollmann-Tepeköylü, Johannes Holfeld   +15 more
doaj   +1 more source

Developing insights into cardiac regeneration [PDF]

Development, 2013
Owing to its intrinsic beauty and biomedical importance, the heart has been the focus of intensive research. The recent EMBO/EMBL-sponsored symposium ‘Cardiac Biology: From Development to Regeneration’ gathered cardiovascular scientists from across the globe to discuss the latest advances in our understanding of the development and growth of the heart,
Christoffels, Vincent M., Pu, William T.
openaire   +3 more sources

Mechanically Stable and Tunable Photoactivated Peptide‐Based Hydrogels for Soft Tissue Adhesion

Advanced Functional Materials, EarlyView.
A collagen‐like peptide hydrogel platform is developed using supramolecular self‐assembly and light‐triggered crosslinking. It creates mechanically stable, tunable hydrogels with cytocompatibility and biodegradability, making them potential soft tissue adhesives.
Alex Ross, Daniel Nguyen, Aidan J. MacAdam, German A. Mercado Salazar, Micaela Gianetti, Ramis Ileri, Marc Ruel, Erik J. Suuronen, Emilio I. Alarcon   +8 more
wiley   +1 more source

Nkx2.5: a crucial regulator of cardiac development, regeneration and diseases

Frontiers in Cardiovascular Medicine, 2023
Cardiomyocytes fail to regenerate after birth and respond to mitotic signals through cellular hypertrophy rather than cellular proliferation. Necrotic cardiomyocytes in the infarcted ventricular tissue are eventually replaced by fibroblasts, generating ...
Ce Cao, Ce Cao, Lei Li, Qian Zhang, Haoran Li, Haoran Li, Ziyan Wang, Aoao Wang, Jianxun Liu, Jianxun Liu   +9 more
doaj   +1 more source

Analysis of pregnancy-associated plasma protein a production in human adult cardiac progenitor cells [PDF]

, 2013
IGF-binding proteins (IGFBPs) and their proteases regulate IGFs bioavailability in multiple tissues. Pregnancy-associated plasma protein A (PAPP-A) is a protease acting by cleaving IGFBP2, 4, and 5, regulating local bioavailability of IGFs.
ANGELINI, FRANCESCO, CHIMENTI, ISOTTA, GIACOMELLO, Alessandro, IONTA, VITTORIA, MESSINA, ELISA, MIRALDI, Fabio, PALA, Alessandro, Piera D'Elia   +7 more
core   +5 more sources

Tissue Engineered Human Elastic Cartilage From Primary Auricular Chondrocytes for Ear Reconstruction

Advanced Functional Materials, EarlyView.
Despite over three decades of research, no tissue‐engineered solution for auricular reconstruction in microtia patients has reached clinical translation. The key challenge lies in generating functional elastic cartilage ex vivo. Here, we integrate synergistic cell‐biomaterial strategies to engineer auricular grafts with mechanical and histological ...
Philipp Fisch, Sandra Kessler, Simone Ponta, Anna Puiggalí‐Jou, Guoliang Lyu, Killian Flégeau, Anastasiya Martyts, Florian Roth, David Fercher, Filippo M. Rijli, Daniel Simmen, Eva Novoa Olivares, Thomas Linder, Marcy Zenobi‐Wong   +13 more
wiley   +1 more source

The Evolving Roles of Cardiac Macrophages in Homeostasis, Regeneration, and Repair [PDF]

, 2021
Santiago Alvarez‐Argote, Caitlin C. O’Meara   +1 more
openalex   +1 more source

Cytokines and chemokines as regulators of skeletal muscle inflammation: presenting the case of Duchenne muscular dystrophy [PDF]

, 2013
Duchenne muscular dystrophy is a severe inherited muscle disease that affects 1 in 3500 boys worldwide. Infiltration of skeletal muscle by inflammatory cells is an important facet of disease pathophysiology and is strongly associated with disease ...
De Bleecker, Jan, De Paepe, Boel
core   +3 more sources