Results 11 to 20 of about 160,558 (349)
Journal of the American College of Cardiology, 2006 The role and even the existence of new myocyte formation in the adult heart remain controversial. Documentation of cell cycle regulators, deoxyribonucleic acid synthesis, and mitotic images has only in part modified the view that myocardial growth can be accomplished exclusively from hypertrophy of an irreplaceable population of differentiated myocytes.
Anversa, Piero +2 more
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Science, 2012 The heart is a pump that is comprised of cardiac myocytes and other cell types and whose proper function is critical to quality of life. The ability to trigger regeneration of heart muscle following injury eludes adult mammals, a deficiency of great clinical impact.
Wen-Yee, Choi, Kenneth D, Poss
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Circulation Research, 2017 Palliative surgery for congenital heart disease has allowed patients with previously lethal heart malformations to survive and, in most cases, to thrive. However, these procedures often place pressure and volume loads on the heart, and over time, these chronic loads can cause heart failure.
Francisco X, Galdos +5 more
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Cardiac Neural Crest and Cardiac Regeneration. [PDF]
Cells, 2022 Neural crest cells (NCCs) are a vertebrate-specific, multipotent stem cell population that have the ability to migrate and differentiate into various cell populations throughout the embryo during embryogenesis. The heart is a muscular and complex organ whose primary function is to pump blood and nutrients throughout the body.
Erhardt S, Wang J.
europepmc +4 more sources
Route 411 to Cardiac Regeneration. [PDF]
JACC Basic Transl Sci, 2022 [Figure: see text]
Van den Bogaert S, Segers VFM.
europepmc +5 more sources
Cardiac regeneration validated [PDF]
Nature Biotechnology, 2015 Naumova et al. reply: We appreciate the comments from Malliaras and Marban1 describing their work on developing imaging markers of therapeutic efficacy2 that was not mentioned in our review3. Owing to the page limitation, we were not able to cite all the literature published on this topic.
Konstantinos, Malliaras +1 more
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Cells, 2023 Background: Antithymocyte globulins (ATG) are T cell-depleting antibodies used in solid organ transplantation for induction therapy in sensitized patients with a high risk of graft rejection.
Dragan Copic +6 more
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Circulation Research, 2004 See related article, pages 911–921 Despite current pharmacological and whole organ transplantation strategies, advanced heart failure remains a common and deadly disease.1 Limited availability of donor organs for use in orthotopic heart transplantation has prompted examination of alternative therapeutic strategies directed toward patients with ...
Daniel J. Garry, Cindy M. Martin
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The Secretome of Irradiated Peripheral Mononuclear Cells Attenuates Hypertrophic Skin Scarring
Pharmaceutics, 2023 Hypertrophic scars can cause pain, movement restrictions, and reduction in the quality of life. Despite numerous options to treat hypertrophic scarring, efficient therapies are still scarce, and cellular mechanisms are not well understood.
Vera Vorstandlechner +7 more
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Nature Communications, 2021 Mechanisms triggering hypertrophic scar formation remain poorly understood. Here the authors perform scRNA-seq on mature human hypertrophic scars and developing scars in mice to identify the serine proteases dipeptidyl-peptidase 4 and urokinase as key ...
Vera Vorstandlechner +12 more
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