Results 41 to 50 of about 160,558 (349)
Cell-based gene therapy for mending infarcted hearts [PDF]
, 2011 The goal of this study was to analyse the efficiency of a combinatorial cell/growth factor therapy to improve function of infarcted murine hearts. The Insulin-like Growth Factor-1 (IGF-1) isoform, IGF-1Ea, has been shown to reduce scar formation and ...
Poudel, Bhawana, Poudel, Bhawana
core +1 more source
Circular RNAs: Promising Biomarkers for Human Diseases
EBioMedicine, 2018 Circular RNA (circRNA) is a group of endogenous noncoding RNA characterized by a covalently closed cyclic structure lacking poly-adenylated tails. Recent studies have suggested that circRNAs play a crucial role in regulating gene expression by acting as ...
Zhongrong Zhang +2 more
doaj +1 more source
Microvesicles as vehicles for tissue regeneration: Changing of the guards [PDF]
, 2016 Purpose of Review: Microvesicles (MVs) have been recognised as mediators of stem cell function, enabling and guiding their regenerative effects. Recent Findings: MVs constitute one unique size class of extracellular vesicles (EVs) directly shed from ...
Davies, R. Wayne +3 more
core +1 more source
MicroRNAs and Cardiac Regeneration [PDF]
Circulation Research, 2015 The human heart has a limited capacity to regenerate lost or damaged cardiomyocytes after cardiac insult. Instead, myocardial injury is characterized by extensive cardiac remodeling by fibroblasts, resulting in the eventual deterioration of cardiac structure and function.
Conrad P, Hodgkinson +4 more
openaire +2 more sources
Cardiac Fibroblasts and Myocardial Regeneration [PDF]
Frontiers in Bioengineering and Biotechnology, 2021 The billions of cardiomyocytes lost to acute myocardial infarction (MI) cannot be replaced by the limited regenerative capacity of adult mammalian hearts, and despite decades of research, there are still no clinically effective therapies for remuscularizing and restoring damaged myocardial tissue.
Wangping Chen +4 more
openaire +3 more sources
Physiological conditions influencing regenerative potential of stem cells [PDF]
, 2016 Stem cells are being used in the treatment of cardivovascular diseases. Here, we review the physiologic and pathologic conditions that impact the regenerative potential of stem cells in the treatment of cardiovascular diseases which include the influence
Avitabile, Daniele +3 more
core +1 more source
Mechanisms of Cardiac Regeneration [PDF]
Developmental Cell, 2016 Adult humans fail to regenerate their hearts following injury, and this failure to regenerate myocardium is a leading cause of heart failure and death worldwide. Although all adult mammals appear to lack significant cardiac regeneration potential, some vertebrates can regenerate myocardium throughout life. In addition, new studies indicate that mammals
Uygur, Aysu, Lee, Richard T.
openaire +2 more sources
Nature Communications, 2021 Endothelial cells play a critical role in the adaptation of tissues to injury and show a remarkable plasticity. Here the authors show, using single cell sequencing, that endothelial cells acquire a transient mesenchymal state associated with metabolic ...
Lukas S. Tombor +23 more
doaj +1 more source
Non-coding RNAs in Cardiac Regeneration
Frontiers in Physiology, 2021 The adult heart has a limited capacity to replace or regenerate damaged cardiac tissue following severe myocardial injury. Thus, therapies facilitating the induction of cardiac regeneration holds great promise for the treatment of end-stage heart failure,
Ting Yuan, Jaya Krishnan
doaj +1 more source
Nanopatterned acellular valve conduits drive the commitment of blood-derived multipotent cells [PDF]
, 2016 Considerable progress has been made in recent years toward elucidating the correlation among nanoscale topography, mechanical properties, and biological behavior of cardiac valve substitutes.
Aguiari, Paola +11 more
core +2 more sources