Results 51 to 60 of about 160,558 (349)

CADUCEUS, SCIPIO, ALCADIA: Cell therapy trials using cardiac-derived cells for patients with post myocardial infarction LV dysfunction, still evolving. [PDF]

, 2012
The early results of the CArdiosphere-Derived aUtologous stem CElls to reverse ventricUlar dySfunction study were recently published in the Lancet [1]. This study is a phase 1 prospective randomised study, performed at two centres. The study was designed
Terrovitis, J, Yacoub, MH
core   +2 more sources

Direct Cardiac Cellular Reprogramming for Cardiac Regeneration [PDF]

Current Treatment Options in Cardiovascular Medicine, 2016
Direct cardiac cellular reprogramming of endogenous cardiac fibroblasts directly into induced cardiomyocytes is a highly feasible, promising therapeutic option for patients with advanced heart failure. The most successful cardiac reprogramming strategy will likely be a multimodal approach involving an optimal combination of cardio-differentiating ...
Vivekkumar, Patel, Megumi, Mathison, Vivek P, Singh, Jianchang, Yang, Todd K, Rosengart   +4 more
openaire   +2 more sources

MicroRNAs in heart and circulation during physical exercise

Journal of Sport and Health Science, 2018
Exercise training is beneficial to the cardiovascular system. MicroRNAs (miRNAs, miRs) are a class of conserved non-coding RNAs and play a wide-ranging role in the regulation of eukaryotic gene expression.
Lijun Wang, Yicheng Lv, Guoping Li, Junjie Xiao   +3 more
doaj   +1 more source

Cardiac protection by pirfenidone after myocardial infarction: a bioinformatic analysis

Scientific Reports, 2022
Left ventricular (LV) remodeling after myocardial infarction (MI) is promoted by an intense fibrotic response, which could be targeted by the anti-fibrotic drug pirfenidone.
Alberto Aimo, Oriol Iborra-Egea, Nicola Martini, Carolina Galvez-Monton, Silvia Burchielli, Giorgia Panichella, Claudio Passino, Michele Emdin, Antoni Bayes-Genis   +8 more
doaj   +1 more source

The Effect of Paracrine Factors Released by Irradiated Peripheral Blood Mononuclear Cells on Neutrophil Extracellular Trap Formation

Antioxidants, 2022
Neutrophil extracellular trap (NET)-formation represents an important defence mechanism for the rapid clearance of infections. However, exaggerated NET formation has been shown to negatively affect tissue-regeneration after injury.
Katharina Klas, Anna S. Ondracek, Thomas M. Hofbauer, Andreas Mangold, Karin Pfisterer, Maria Laggner, Dragan Copic, Martin Direder, Daniel Bormann, Hendrik Jan Ankersmit, Michael Mildner   +10 more
doaj   +1 more source

Introductory editorial: drug-eluting stents or drug-eluting grafts? Insights from proteomic analysis [PDF]

, 2017
No abstract ...
Al-Attar, Nawwar, Coccia, Raffaella, Di Domenico, Fabio, Nappi, Francesco, Perluigi, Marzia, Spadaccio, Cristiano   +5 more
core   +1 more source

METTL14 is required for exercise-induced cardiac hypertrophy and protects against myocardial ischemia-reperfusion injury

Nature Communications, 2022
The benefit of regular exercise on the heart has been well documented but the role of RNA m6A modification in exercise-induced cardiac remodelling remains largely unknown.
Lijun Wang, Jiaqi Wang, Pujiao Yu, Jingyi Feng, Gui-e Xu, Xuan Zhao, Tianhui Wang, H. Immo Lehmann, Guoping Li, Joost P. G. Sluijter, Junjie Xiao   +10 more
doaj   +1 more source

"Of Mice and Measures": A Project to Improve How We Advance Duchenne Muscular Dystrophy Therapies to the Clinic [PDF]

, 2018
A new line of dystrophic mdx mice on the DBA/2J (D2) background has emerged as a candidate to study the efficacy of therapeutic approaches for Duchenne muscular dystrophy (DMD). These mice harbor genetic polymorphisms that appear to increase the severity
Aartsma-Rus, A., Bogdanik, L, Davies, K, De Luca, A, Demonbruen, Ar, Duan, D, Elsey, D, Fukada, Si, Girgenrath, M, Gonzalez, Jp, Gordish-Dressman, H, Grounds, Md, Heydemann, A, Kreibich, A, Lutz, C, Nagaraju, K, Nichols, A, Partridge, T, Passini, M, Pazze, Ld, Sanarica, F, Schnell, Fj, Spencer, M, Spurney, C, van Putten, M, Wells, Dj, Willmann, R, Yokota, T, Young, Cs, Zhong, Z   +29 more
core   +3 more sources

Metabolic Regulation of Cardiac Regeneration

Frontiers in Cardiovascular Medicine, 2022
The mortality due to heart diseases remains highest in the world every year, with ischemic cardiomyopathy being the prime cause. The irreversible loss of cardiomyocytes following myocardial injury leads to compromised contractility of the remaining myocardium, adverse cardiac remodeling, and ultimately heart failure.
Xuewen Duan, Xingguang Liu, Zhenzhen Zhan   +2 more
openaire   +3 more sources

Cardiosphere-derived cells suppress allogeneic lymphocytes by production of PGE2 acting via the EP4 receptor [PDF]

, 2018
derived cells (CDCs) are a cardiac progenitor cell population, which have been shown to possess cardiac regenerative properties and can improve heart function in a variety of cardiac diseases. Studies in large animal models have predominantly focussed on
A Augello, AJ Nauta, AJ Poncelet, AJ White, AS Boyd, B Hegyi, B Nadal-Ginard, C Basso, C Boriesson, C Liang, CH Chen, CY Xiao, D Carrade, D Pinheiro, DR Davis, DY Nah, E Ingulli, EM Oxford, G Couto de, G Wess, G Wess, GO Ramirez-Yañez, H Kanazawa, H Takeyama, I Chimenti, JA Dixon, JG Bartolucci, JM Angles, JW Kang, K Blanc Le, K Malliaras, K Malliaras, K Sato, KM Meurs, L Cambier, L Grigorian-Shamagian, L Lauden, L Öberg, LC Dutton, LJ Kennedy, M Haidar, MA Aminzadeh, MD Nicola, ME Bernardo, ME Campian, MM Duffy, MT Hensley, MT Hensley, N Kvirkvelia, O Campuzano, P Ross, PV Johnston, Q Guan, R Gallet, R Meisel, R Ramasamy, RR Makkar, S Aggarwal, S Simpson, SJ Jansen of Lorkeers, SR Houser, ST Lee, T Maślanka, TL Lynch, TS Li, WS Lee, Y Ding, Y Sun, YC Hsueh, Z Yan   +69 more
core   +2 more sources