Nature Communications, 2022 The benefit of regular exercise on the heart has been well documented but the role of RNA m6A modification in exercise-induced cardiac remodelling remains largely unknown.
Lijun Wang +10 more
doaj +1 more source
Angiotensin II type 1 receptor antagonists alleviate muscle pathology in the mouse model for laminin-alpha2-deficient congenital muscular dystrophy (MDC1A) [PDF]
, 2012 BACKGROUND: Laminin-alpha2-deficient congenital muscular dystrophy (MDC1A) is a severe muscle-wasting disease for which no curative treatment is available.
Lin, Shuo +2 more
core +1 more source
Cardiac protection by pirfenidone after myocardial infarction: a bioinformatic analysis
Scientific Reports, 2022 Left ventricular (LV) remodeling after myocardial infarction (MI) is promoted by an intense fibrotic response, which could be targeted by the anti-fibrotic drug pirfenidone.
Alberto Aimo +8 more
doaj +1 more source
Antioxidants, 2022 Neutrophil extracellular trap (NET)-formation represents an important defence mechanism for the rapid clearance of infections. However, exaggerated NET formation has been shown to negatively affect tissue-regeneration after injury.
Katharina Klas +10 more
doaj +1 more source
A novel closed-chest porcine model of chronic ischemic heart failure suitable for experimental research in cardiovascular disease [PDF]
, 2013 Cardiac pathologies are among the leading causes of mortality and morbidity in industrialized countries, with myocardial infarction (MI) representing one of the major conditions leading to heart failure (HF).
Antonio Amodeo +15 more
core +3 more sources
Polymer- and Hybrid-Based Biomaterials for Interstitial, Connective, Vascular, Nerve, Visceral and Musculoskeletal Tissue Engineering [PDF]
, 2020 In this review, materials based on polymers and hybrids possessing both organic and inorganic contents for repairing or facilitating cell growth in tissue engineering are discussed.
Abalymov, Anatolii +2 more
core +1 more source
Metabolic Regulation of Cardiac Regeneration
Frontiers in Cardiovascular Medicine, 2022 The mortality due to heart diseases remains highest in the world every year, with ischemic cardiomyopathy being the prime cause. The irreversible loss of cardiomyocytes following myocardial injury leads to compromised contractility of the remaining myocardium, adverse cardiac remodeling, and ultimately heart failure.
Xuewen Duan +2 more
openaire +3 more sources
CADUCEUS, SCIPIO, ALCADIA: Cell therapy trials using cardiac-derived cells for patients with post myocardial infarction LV dysfunction, still evolving. [PDF]
, 2012 The early results of the CArdiosphere-Derived aUtologous stem CElls to reverse ventricUlar dySfunction study were recently published in the Lancet [1]. This study is a phase 1 prospective randomised study, performed at two centres. The study was designed
Terrovitis, J, Yacoub, MH
core +2 more sources
Revascularization of chronic total occlusion coronary artery and cardiac regeneration
Frontiers in Cardiovascular Medicine, 2022 Coronary chronic total occlusion (CTO) contributes to the progression of heart failure in patients with ischemic cardiomyopathy. Randomized controlled trials demonstrated that percutaneous coronary intervention (PCI) for CTO significantly improves angina
Ruoxi Liao +4 more
doaj +1 more source
Guided Tissue Regeneration in Heart Valve Replacement: From Preclinical Research to First-in-Human Trials [PDF]
, 2015 Heart valve tissue-guided regeneration aims to offer a functional and viable alternative to current prosthetic replacements. Not requiring previous cell seeding and conditioning in bioreactors, such exceptional tissue engineering approach is a very ...
Gerosa, Gino, Iop, Laura
core +4 more sources