Results 31 to 40 of about 86,066 (247)

The Long and Winding Road to Cardiac Regeneration

Applied Sciences, 2023
Cardiac regeneration is a critical endeavor in the treatment of heart diseases, aimed at repairing and enhancing the structure and function of damaged myocardium.
Anna Maria Sacco, Clotilde Castaldo, Franca Di Meglio, Daria Nurzynska, Stefano Palermi, Rocco Spera, Rossana Gnasso, Giorgio Zinno, Veronica Romano, Immacolata Belviso   +9 more
doaj   +1 more source

Challenges in Cardiac Tissue Engineering [PDF]

Tissue Engineering Part B: Reviews, 2010
Cardiac tissue engineering aims to create functional tissue constructs that can reestablish the structure and function of injured myocardium. Engineered constructs can also serve as high-fidelity models for studies of cardiac development and disease. In a general case, the biological potential of the cell-the actual "tissue engineer"-is mobilized by ...
Gordana, Vunjak-Novakovic, Nina, Tandon, Amandine, Godier, Robert, Maidhof, Anna, Marsano, Timothy P, Martens, Milica, Radisic   +6 more
openaire   +2 more sources

Ventricular stabilization with a customized decellularized cardiac ECM-based scaffold after myocardial infarction alters gene expression in a rodent LAD-ligation model

Frontiers in Bioengineering and Biotechnology, 2022
Objectives: Decellularized extracellular matrix (dECM) is increasingly used in a wide range of regenerative medicine applications and may also offer the potential to support injured myocardium.
Hug Aubin, Hug Aubin, Lenard Rath, Alexandra Vey, Vera Schmidt, Vera Schmidt, Mareike Barth, Mareike Barth, Elvira Weber, Elvira Weber, Artur Lichtenberg, Artur Lichtenberg, Payam Akhyari, Payam Akhyari   +13 more
doaj   +1 more source

Graphene-Based Scaffolds: Fundamentals and Applications for Cardiovascular Tissue Engineering

Frontiers in Bioengineering and Biotechnology, 2021
Cardiac tissue engineering requires materials that can faithfully recapitulate and support the native in vivo microenvironment while providing a seamless bioelectronic interface.
Alex Savchenko, Rose T. Yin, Dmitry Kireev, Igor R. Efimov, Elena Molokanova, Elena Molokanova   +5 more
doaj   +1 more source

Construction of cardiac fibrosis for biomedical research

Smart Medicine, 2023
Cardiac remodeling is critical for effective tissue recuperation, nevertheless, excessive formation and deposition of extracellular matrix components can result in the onset of cardiac fibrosis.
Yixuan Shang, Rui Liu, Jingjing Gan, Yuzhi Yang, Lingyun Sun   +4 more
doaj   +1 more source

2D Materials for Cardiac Tissue Repair and Regeneration

Frontiers in Cardiovascular Medicine, 2022
Cardiovascular diseases (CVDs) have a massive impact on human health. Due to the limited regeneration capacity of adult heart tissue, CVDs are the leading cause of death and disability worldwide.
Cemile Gokce, Cansu Gurcan, Cansu Gurcan, Lucia Gemma Delogu, Acelya Yilmazer, Acelya Yilmazer   +5 more
doaj   +1 more source

Pulsatile tubular cardiac tissues fabricated by wrapping human iPS cells-derived cardiomyocyte sheets

Regenerative Therapy, 2019
The purpose of this study was to fabricate pulsatile tubular cardiac tissue using cell sheet based-tissue engineering. First, we fabricated human induced pluripotent stem cell (hiPSc)-derived cardiomyocyte sheets and normal human dermal fibroblast (NHDF)
Shinpei Tsuruyama, Katsuhisa Matsuura, Katsuhisa Sakaguchi, Tatsuya Shimizu   +3 more
doaj   +1 more source

Cardiac Conduction through Engineered Tissue [PDF]

The American Journal of Pathology, 2006
In children, interruption of cardiac atrioventricular (AV) electrical conduction can result from congenital defects, surgical interventions, and maternal autoimmune diseases during pregnancy. Complete AV conduction block is typically treated by implanting an electronic pacemaker device, although long-term pacing therapy in pediatric patients has ...
Yeong-Hoon, Choi, Christof, Stamm, Peter E, Hammer, Kevin F, Kwaku, Jennifer J, Marler, Ingeborg, Friehs, Mara, Jones, Christine M, Rader, Nathalie, Roy, Mau-Thek, Eddy, John K, Triedman, Edward P, Walsh, Francis X, McGowan, Pedro J, del Nido, Douglas B, Cowan   +14 more
openaire   +2 more sources

Application of conductive hydrogels in cardiac tissue engineering

STEMedicine, 2023
The fatality rate of myocardial infarction ranks first in cardiovascular disease, which is myocardial necrosis caused by persistent ischemia and hypoxia caused by coronary artery occlusion. Myocardial infarction leads to the irreversible loss of a large
Xiaoyi Ren, Ziyun Jiang, Mingliang Tang
doaj   +1 more source

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source