Results 31 to 40 of about 53,087 (243)

Cardiolipin exposure on the outer mitochondrial membrane modulates α-synuclein

Nature Communications, 2018
Cardiolipin is a phospholipid component of the inner mitochondrial membrane. Here the authors demonstrate that cardiolipin interacts with mutant α-synuclein, and that impaired cardiolipin function can lead to spread of α-synuclein between neurons.
Tammy Ryan, Vladimir V. Bamm, Morgan G. Stykel, Carla L. Coackley, Kayla M. Humphries, Rhiannon Jamieson-Williams, Rajesh Ambasudhan, Dick D. Mosser, Stuart A. Lipton, George Harauz, Scott D. Ryan   +10 more
doaj   +1 more source

Separation and characterization of cardiolipin molecular species by reverse-phase ion pair high-performance liquid chromatography-mass spectrometry1

Journal of Lipid Research, 2010
An improved high-performance liquid chromatography-mass spectrometry method for the separation and characterization of cardiolipin molecular species is presented.
Paul E. Minkler, Charles L. Hoppel
doaj   +1 more source

Structural insights into cardiolipin replacement by phosphatidylglycerol in a cardiolipin-lacking yeast respiratory supercomplex

Nature Communications, 2023
Cardiolipin is a hallmark phospholipid of mitochondrial membranes. Despite established significance of cardiolipin in supporting respiratory supercomplex organization, a mechanistic understanding of this lipid-protein interaction is still lacking.
Corey F. Hryc, Venkata K. P. S. Mallampalli, Evgeniy I. Bovshik, Stavros Azinas, Guizhen Fan, Irina I. Serysheva, Genevieve C. Sparagna, Matthew L. Baker, Eugenia Mileykovskaya, William Dowhan   +9 more
doaj   +1 more source

Oxidative stress is tightly regulated by cytochrome c phosphorylation and respirasome factors in mitochondria [PDF]

, 2018
Respiratory cytochrome c has been found to be phosphorylated at tyrosine 97 in the postischemic brain upon neuroprotective insulin treatment, but how such posttranslational modification affects mitochondrial metabolism is unclear.
Díaz Moreno, Irene, Díaz Quintana, Antonio Jesús, Elena-Real, Carlos A., García Mauriño, Sofía M., González Arzola, Katiuska, Guerra Castellano, Alejandra, Pérez Mejías, Gonzalo, Rosa Acosta, Miguel Ángel de la   +7 more
core   +1 more source

Cardiolipin Synthesis and Outer Membrane Localization Are Required for Shigella flexneri Virulence

mBio, 2017
Cardiolipin, an anionic phospholipid that resides at the poles of the inner and outer membranes, is synthesized primarily by the putative cardiolipin synthase ClsA in Shigella flexneri. An S.
Rachael M. Rossi, Lauren Yum, Hervé Agaisse, Shelley M. Payne   +3 more
doaj   +1 more source

Cardiolipin’s Remodeling Rules Revealed: The Role of the Cellular Lipidome

Cell Reports, 2020
In this issue of Cell Reports, Oemer et al. (2020) define the acyl chain composition of cardiolipin and other lipid classes in murine tissues. They then employ artificial neural networks to predict mechanisms that govern cardiolipin tissue specificity ...
Olivia L. Sniezek, Arianna F. Anzmann, Steven M. Claypool, Hilary J. Vernon   +3 more
doaj   +1 more source

Changes in membrane lipids drive increased endocytosis following Fas ligation [PDF]

, 2017
Once activated, some surface receptors promote membrane movements that open new portals of endocytosis, in part to facilitate the internalization of their activated complexes.
Degli Esposti, Mauro, Garofalo, Tina, Khosravi Far, Roya, Longo, Agostina, Malorni, Walter, Matarrese, Paola, Misasi, Roberta, Recalchi, Serena, Sorice, Maurizio, Tinari, Antonella   +9 more
core   +1 more source

Analysis of neuronal cardiolipin and monolysocardiolipin from biological samples with cyclic ion mobility mass spectrometry

Frontiers in Physiology
The mitochondrial phospholipid cardiolipin (CL) is essential for proper mitochondrial function and energy production. Cardiolipin has four distinct fatty acid tails with varying expression compositions, resulting in a highly variable tissue-specific ...
Katlynn J. Emaus, Katlynn J. Emaus, Carmen A. Dunbar, Carmen A. Dunbar, Joseph Caruso, Brandon T. Ruotolo, Joseph M. Wider, Joseph M. Wider, Joseph M. Wider, Thomas H. Sanderson, Thomas H. Sanderson, Thomas H. Sanderson, Thomas H. Sanderson   +12 more
doaj   +1 more source

Acylation of monolysocardiolipin in rat heart

Journal of Lipid Research, 1999
Cardiolipin is a major mitochondrial membrane glycerophospholipid in the mammalian heart. In this study, the ability of the isolated intact rat heart to remodel cardiolipin and the mitochondrial enzyme activities that reacylate monolysocardiolipin to ...
Brian J. Ma, William A. Taylor, Vernon W. Dolinsky, Grant M. Hatch   +3 more
doaj   +1 more source

Impaired cardiac and skeletal muscle bioenergetics in children, adolescents, and young adults with Barth syndrome [PDF]

, 2017
Barth syndrome (BTHS) is an X‐linked condition characterized by altered cardiolipin metabolism and cardioskeletal myopathy. We sought to compare cardiac and skeletal muscle bioenergetics in children, adolescents, and young adults with BTHS and unaffected
Altschuld, American College of Sports Medicine, Bahi, Barth, Bashir, Bione, Bissler, Cade, Cade, Chance, Chance, Conway, Edwards, El-Sharkawy, Gomez, Gonzalvez, Hiona, Hom, Hudsmith, Ingwall, Kemp, Kemp, Kemp, Kemp, Kushmerick, Lang, Lanza, Lanza, Larson-Meyer, Layec, Liu, Matthews, Meyer, Meyer, Minotti, Naressi, Nascimben, Neubauer, Powers, Ratel, Roussel, Sapega, Schlame, Sgobbo, Smith, Spencer, Spencer, Spoladore, Takahashi, Taylor, Taylor, Thaveau, Thompson, Tonson, Vanhamme, Wang, Wasserman, Waters, Xu, Yao, Zhang, Zoll   +61 more
core   +2 more sources