Results 11 to 20 of about 127,833 (167)

Unique patterns of cardiogenic and fibrotic gene expression in rat cardiac fibroblasts [PDF]

Veterinary World, 2020
Background and Aim: Cardiac fibroblasts are important for both normal and pathological states of the heart, but the knowledge in cell physiology and genomics is still poorly understood.
Kittipong Tachampa, Tuempong Wongtawan
doaj   +1 more source

Role of Mitophagy in Coronary Heart Disease: Targeting the Mitochondrial Dysfunction and Inflammatory Regulation

Frontiers in Cardiovascular Medicine, 2022
Coronary heart disease (CHD) is one of the main causes of death worldwide. In the past few decades, several in-depth research on the pathological mechanisms and effective treatment methods for CHD have been conducted.
Mingxuan Liu, Ying Wu
doaj   +1 more source

Impact of Opuntia ficus-indica Fruit Extracts on Toxicity Induced by Doxorubicin in Cardiomyocytes [PDF]

Research Journal of Pharmacognosy
Background and objectives: Doxorubicin is an antineoplastic agent whose administration may cause cardiotoxicity. Opuntia ficus-indica is a widely consumed cactus species with nutritional and antioxidant value.
Leila Safaeian*, Masoud Sadeghi-Dinani, Arezou Ramezani, Mansooreh Asghari-Varzaneh   +3 more
doaj   +1 more source

The Regulator of G Protein Signaling Homologous Domain of G Protein-Coupled Receptor Kinase 2 Mediates Short-Term Desensitization of β3-Adrenergic Receptor

Frontiers in Pharmacology, 2020
G protein coupled receptor (GPCR) kinases (GRKs) are key regulators of GPCR signaling. Canonical mechanism of GPCR desensitization involves receptor phosphorylation by GRKs followed by arrestin recruitment and uncoupling from heterotrimeric G protein ...
Emiliana Echeverría, Emiliana Echeverría, Maia Cabrera, Maia Cabrera, Valeria Burghi, Valeria Burghi, Máximo Sosa, Máximo Sosa, Sonia Ripoll, Sonia Ripoll, Agustín Yaneff, Agustín Yaneff, Federico Monczor, Federico Monczor, Carlos Davio, Carlos Davio, Carina Shayo, Natalia Fernández, Natalia Fernández   +18 more
doaj   +1 more source

The β2-Subunit of Voltage-Gated Calcium Channels Regulates Cardiomyocyte Hypertrophy

Frontiers in Cardiovascular Medicine, 2021
L-type voltage-gated calcium channels (LTCCs) regulate crucial physiological processes in the heart. They are composed of the Cavα1 pore-forming subunit and the accessory subunits Cavβ, Cavα2δ, and Cavγ. Cavβ is a cytosolic protein that regulates channel
Simone Pickel, Yiliam Cruz-Garcia, Sandra Bandleon, Katalin Barkovits, Katalin Barkovits, Cornelia Heindl, Katharina Völker, Marco Abeßer, Kathy Pfeiffer, Kathy Pfeiffer, Alice Schaaf, Katrin Marcus, Katrin Marcus, Petra Eder-Negrin, Michaela Kuhn, Michaela Kuhn, Erick Miranda-Laferte, Erick Miranda-Laferte   +17 more
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Differentiation of cardiomyocyte.

Folia Pharmacologica Japonica, 2000
In the recent decade, remarkable progress has been made in the field of cardiac development through the use of molecular, biological and genetic techniques. Several genes that regulate this process have been cloned, and their functions have been analyzed in vivo and in vitro.
T, Oka, I, Komuro
openaire   +3 more sources

Communication Between Cardiomyocytes and Fibroblasts During Cardiac Ischemia/Reperfusion and Remodeling: Roles of TGF-β, CTGF, the Renin Angiotensin Axis, and Non-coding RNA Molecules

Frontiers in Physiology, 2021
Communication between cells is a foundational concept for understanding the physiology and pathology of biological systems. Paracrine/autocrine signaling, direct cell-to-cell interplay, and extracellular matrix interactions are three types of cell ...
Raúl Flores-Vergara, Raúl Flores-Vergara, Ivonne Olmedo, Ivonne Olmedo, Pablo Aránguiz, Jaime Andrés Riquelme, Jaime Andrés Riquelme, Raúl Vivar, Zully Pedrozo, Zully Pedrozo, Zully Pedrozo   +10 more
doaj   +1 more source

IMMUNOHISTOCHEMICAL EVALUATION OF VASOENDOTHELIAL GROWTH FACTOR RECEPTOR-2 (VEGFR2) EXPRESSION IN RAT CARDIOMYOCYTES UNDER DOXORUBICIN AND BETULONIC ACID AMIDE ADMINISTRATION

Сибирский научный медицинский журнал, 2019
The aim of the study is to perform an immunohistochemical analysis of the expression of the vascular endothelial growth factor receptor 2 (VEGFR2) in the myocardium of Wistar rats in doxorubicin-induced cardiomyopathy and the administration of betulonic ...
L. L. Elena, M. M. Mzhelskaya, E. V. Koldysheva, M. G. Klinnikova   +3 more
doaj   +1 more source

Ginsenoside Re Treatment Attenuates Myocardial Hypoxia/Reoxygenation Injury by Inhibiting HIF-1α Ubiquitination

Frontiers in Pharmacology, 2020
Previous studies have shown an attenuating effect of ginsenoside Re on myocardial injury induced by hypoxia/reoxygenation (H/R). However, the underlying mechanism remains unclear.
Huiyuan Sun, Huiyuan Sun, Huiyuan Sun, Shukuan Ling, Dingsheng Zhao, Jianwei Li, Yang Li, Hua Qu, Ruikai Du, Ying Zhang, Feng Xu, Yuheng Li, Caizhi Liu, Guohui Zhong, Shuai Liang, Zizhong Liu, Xingcheng Gao, Xiaoyan Jin, Yingxian Li, Dazhuo Shi   +19 more
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AARS2 ameliorates myocardial ischemia via fine-tuning PKM2-mediated metabolism

eLife
AARS2, an alanyl-tRNA synthase, is essential for protein translation, but its function in mouse hearts is not fully addressed. Here, we found that cardiomyocyte-specific deletion of mouse AARS2 exhibited evident cardiomyopathy with impaired cardiac ...
Zongwang Zhang, Lixia Zheng, Yang Chen, Yuanyuan Chen, Junjie Hou, Chenglu Xiao, Xiaojun Zhu, Shi-Min Zhao, Jing-Wei Xiong   +8 more
doaj   +1 more source