Journal of Cellular and Molecular Medicine, Volume 30, Issue 9, May 2026.ABSTRACT Although Doxorubicin (Dox) is an effective anticancer drug, it can cause severe cardiotoxicity. While several mechanisms have been proposed to explain Dox‐induced cardiomyopathy (DIC), strategies to prevent it remain limited. In previous research on isolated cardiomyocytes, we identified that Empagliflozin (EMPA), an antidiabetic drug ...
Akshi Malik +6 more
wiley +1 more source
Enhanced Na\u3csup\u3e+\u3c/sup\u3e/H\u3csup\u3e+\u3c/sup\u3e Exchange During Ischemia and Reperfusion Impairs Mitochondrial Bioenergetics and Myocardial Function [PDF]
, 2008 Inhibition of Na+/H+ exchange (NHE) during ischemia reduces cardiac injury due to reduced reverse mode Na+/Ca2+ exchange. We hypothesized that activating NHE-1 at buffer pH 8 during ischemia increases mitochondrial oxidation, Ca2+ overload, and reactive ...
Aldakkak, Mohammed +4 more
core +1 more source
Methods and pharmaceutical compositions for the cardioprotection [PDF]
, 2014 The present invention relates to methods and pharmaceutical compositions for cardioprotection of subjects who experienced a myocardial infarction. In particular, the present invention relates to a ligand of the sonic hedgehog signaling pathway for use in
A. Lacampagne +8 more
core +1 more source
Aging-associated Alteration in the Cardiac MIF-AMPK Cascade in Response to Ischemic Stress [PDF]
, 2008 An important role for a macrophage migration inhibitory factor (MIF)-AMP-activated protein kinase (AMPK) signaling pathway in ameliorating myocardial damage following ischemia/reperfusion has been described. An aging-associated reduction in AMPK activity
Erin Lane +7 more
core +1 more source
Enhanced charge-independent Mitochondrial Free Ca\u3csup\u3e2+\u3c/sup\u3e and Attenuated ADP-induced NADH Oxidation by Isoflurane: Implications for Cardioprotection [PDF]
, 2012 Modulation of mitochondrial free Ca2 + ([Ca2 +]m) is implicated as one of the possible upstream factors that initiates anesthetic-mediated cardioprotection against ischemia–reperfusion (IR) injury.
Agarwal, Bhawana +4 more
core +1 more source
USAGE OF CARDIOPROTECTION PRINCIPLES IN TREATING CHRONIC HEART FAILURE
Российский кардиологический журнал, 2000 Usage of cardioprotection principles in treating chronic heart failure.
M. A. Gurevich, N. P. Sanina
doaj
Erratum. Cardioprotection During Myocardial Infarction in Diabetic Cardiomyopathy. Diabetes 2025;74:1021-1032. [PDF]
DiabetesAlcover S +7 more
europepmc +1 more source
Remote ischemic conditioning for safe cardioprotection in cardio-oncology? [PDF]
Basic Res CardiolTotzeck M, Rassaf T.
europepmc +1 more source
Mesenchymal Stem Cell-Derived Extracellular Vesicles in Myocardial Ischemia-Reperfusion Injury: A Comprehensive Review. [PDF]
Biology (Basel)Bonanni L, Ferri N.
europepmc +1 more source
Protecting the Heart Against Anthracyclines: The Elusive Search for the Optimal Cardiomyocyte Model. [PDF]
JACC Basic Transl SciNarvaez-Paliza JM, Asnani A.
europepmc +1 more source