Results 11 to 20 of about 20,955 (188)

Cardioprotective mechanisms of mitochondria-targeted S-nitrosating agent and adenosine triphosphate-sensitive potassium channel opener are mutually exclusiveCentral MessagePerspective

JTCVS Open, 2021
Background: Myocytes exposed to stress exhibit significant swelling and reduced contractility. These consequences are ameliorated by adenosine triphosphate–sensitive potassium (KATP) channel opener diazoxide (DZX) via an unknown mechanism.
Thaniyyah Ahmad, MD, Jie Wang, MD, Ana Karen Velez, MD, Alejandro Suarez-Pierre, MD, Kathleen C. Clement, MD, Jie Dong, Krisztian Sebestyen, MS, Joseph K. Canner, MHS, Michael P. Murphy, PhD, Jennifer S. Lawton, MD   +9 more
doaj   +1 more source

HSP90-Mediates Liraglutide Preconditioning-Induced Cardioprotection by Inhibiting C5a and NF-κB

Journal of Investigative Surgery, 2022
Objective We previously showed that HSP90 is involved in postconditioning cardioprotection by inhibiting complement C5a. Here, we investigated whether HSP90-mediated C5a/NF-κB inhibition is responsible for the cardioprotection conferred by liraglutide ...
Shi-Tao He, Dong-Xiao Wang, Jian-Jun Meng, Xiao-Fang Cheng, Qi Bi, Guo-Qiang Zhong, Rong-Hui Tu   +6 more
doaj   +1 more source

Melatonin in Heart Failure: A Promising Therapeutic Strategy?

Molecules, 2018
Heart failure is a multifactorial clinical syndrome characterized by the inability of the heart to pump sufficient blood to the body. Despite recent advances in medical management, poor outcomes in patients with heart failure remain very high.
Frederic Nduhirabandi, Gerald J. Maarman   +1 more
doaj   +1 more source

Targeting myocardial equilibrative nucleoside transporter ENT1 provides cardioprotection by enhancing myeloid Adora2b signaling

JCI Insight, 2023
Previous studies implicate extracellular adenosine signaling in attenuating myocardial ischemia and reperfusion injury (IRI). This extracellular adenosine signaling is terminated by its uptake into cells by equilibrative nucleoside transporters (ENTs ...
Wei Ruan, Jiwen Li, Seungwon Choi, Xinxin Ma, Yafen Liang, Ragini Nair, Xiaoyi Yuan, Tingting W. Mills, Holger K. Eltzschig   +8 more
doaj   +1 more source

Defective high-density lipoprotein lipoprotection in type 2 diabetes during acute myocardial infarction is rescued by apolipoprotein M/sphingosine-1-phosphate loading. [PDF]

Diabetes Obes Metab
Abstract Aims Mortality of patients with type 2 diabetes (T2D) after acute myocardial infarction (AMI) is tremendous and massively increased compared to non‐T2D individuals. The reasons are unclear. High‐density lipoprotein (HDL) conducts lipoprotection during AMI, leading to improved outcomes.
Vogt J, Benkhoff M, Schröder NH, Hu H, Dannenberg L, Keul P, Sarabhai T, Bódis KB, Zeus T, Wollnitzke P, Kelm M, Polzin A, Levkau B.   +12 more
europepmc   +2 more sources

Opioid-induced Cardioprotection [PDF]

Current Pharmaceutical Design, 2014
Ischemic heart disease and myocardial infarction continue to be leading causes of cardiovascular morbidity and mortality. Activation of opioid, adenosine, bradykinin, adrenergic and other G-protein coupled receptors has been found to be cardioprotective.
Katsuya, Tanaka, Judy R, Kersten, Matthias L, Riess   +2 more
openaire   +2 more sources

A brief overview of cardioprotective signaling [PDF]

Arhiv za farmaciju
Cardioprotection is defined as the intrinsic ability of cardiac tissue to withstand challenges like ischemia-reperfusion and different metabolic stresses.
Jovanović Aleksandar
doaj   +1 more source

Sevoflurane and cardioprotection [PDF]

British Journal of Anaesthesia, 2008
The authors hypothesize that the cardioprotective effect of sevoflurane administered throughout CABG operation may be time- and dose-dependent.
L. Siracusano, V. Girasole, V. Piriou, J. Mantz   +3 more
openaire   +3 more sources

Cardioprotection conferred by rooibos (Aspalathus linearis): A mini review to highlight a potential mechanism of action

South African Journal of Science, 2019
A number of cardioprotective interventions have been identified throughout the years, and these include the use of natural antioxidants in sources like rooibos (Aspalathus linearis) tea.
Gerald J. Maarman
doaj   +1 more source

Impact of hyperglycemia on myocardial ischemia–reperfusion susceptibility and ischemic preconditioning in hearts from rats with type 2 diabetes

Cardiovascular Diabetology, 2019
Background The mechanisms underlying increased mortality in patients with diabetes and admission hyperglycemia after an acute coronary syndrome may involve reduced capacity for cardioprotection.
Steen Buus Kristiansen, Kim Bolther Pælestik, Jacob Johnsen, Nichlas Riise Jespersen, Kasper Pryds, Marie Vognstoft Hjortbak, Rebekka Vibjerg Jensen, Hans Erik Bøtker   +7 more
doaj   +1 more source