Results 21 to 30 of about 20,955 (188)
Hexokinases and cardioprotection [PDF]
Journal of Molecular and Cellular Cardiology, 2015 As mediators of the first enzymatic step in glucose metabolism, hexokinases (HKs) orchestrate a variety of catabolic and anabolic uses of glucose, regulate antioxidant power by generating NADPH for glutathione reduction, and modulate cell death processes by directly interacting with the voltage-dependent anion channel (VDAC), a regulatory component of ...
Calmettes, Guillaume +5 more
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Ageing, sex, and cardioprotection [PDF]
British Journal of Pharmacology, 2020 Translation of cardioprotective interventions aimed at reducing myocardial injury during ischaemia–reperfusion from experimental studies to clinical practice is an important yet unmet need in cardiovascular medicine. One particular challenge facing translation is the existence of demographic and clinical factors that influence the pathophysiology of ...
Marisol Ruiz‐Meana +8 more
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M3 subtype of muscarinic acetylcholine receptor promotes cardioprotection via the suppression of miR-376b-5p. [PDF]
PLoS ONE, 2012 The M(3) subtype of muscarinic acetylcholine receptors (M(3)-mAChR) plays a protective role in myocardial ischemia and microRNAs (miRNAs) participate in many cardiac pathophysiological processes, including ischemia-induced cardiac injury.
Zhenyu Pan +14 more
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Biomedical and Biotechnology Research Journal, 2022 Background: Diabetes decreased cardioprotective potential of ischemic postconditioning (IPOC), atrial natriuretic peptide (ANP) induced the cardioprotection against ischemic-reperfusion (I/R) injury. The present study has been designed to investigate the
Garima Gupta +4 more
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Acta Pharmaceutica Sinica B, 2021 Disrupted redox status primarily contributes to myocardial ischemia/reperfusion injury (MIRI). NRF2, the endogenous antioxidant regulator, might provide therapeutic benefits.
Hao Zeng +8 more
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Morphine and remifentanil-induced cardioprotection: its experimental and clinical outcomes [PDF]
Korean Journal of Anesthesiology, 2011 During the past few decades, a large number of animal studies demonstrated that commonly used opioids could provide cardioprotection against ischemia-reperfusion (I/R) injury.
Jin Mo Kim, Young Ho Jang, Jun Kim
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Cardioprotective Brain Mechanisms [PDF]
Arteriosclerosis, Thrombosis, and Vascular Biology, 2012 Progressive cardiac dysfunction after a myocardial infarction (MI) is a major contributor to the high incidence of heart failure in many parts of the world. The initial myocardial injury and the resulting decrease in left ventricular (LV) function activate a variety of systems to sustain the cardiovascular homeostasis.
Frans H H, Leenen, Balwant S, Tuana
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Identifying the Source of a Humoral Factor of Remote (Pre)Conditioning Cardioprotection.
PLoS ONE, 2016 Signalling pathways underlying the phenomenon of remote ischaemic preconditioning (RPc) cardioprotection are not completely understood. The existing evidence agrees that intact sensory innervation of the remote tissue/organ is required for the release ...
Svetlana Mastitskaya +5 more
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Journal of Diabetes Research, 2016 The effect of sevoflurane postconditioning (sevo-postC) cardioprotection is compromised in diabetes which is associated with increased oxidative stress. We hypothesized that antioxidant N-Acetylcysteine may enhance or restore sevo-postC cardioprotection ...
Jiefu Lin +6 more
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Cardioprotection by Adiponectin [PDF]
Trends in Cardiovascular Medicine, 2006 Obesity-related disorders are closely associated with the pathogenesis of cardiovascular disease. Adiponectin is a circulating adipose tissue-derived hormone that is down-regulated in obese individuals. Hypoadiponectinemia has been identified as an independent risk factor for type 2 diabetes, coronary artery disease, and hypertension, and experimental ...
Noriyuki, Ouchi +2 more
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