Evaluating the cancer therapeutic potential of cardiac glycosides [PDF]
, 2014 Cardiac glycosides, also known as cardiotonic steroids, are a group of natural products that share a steroid-like structure with an unsaturated lactone ring and the ability to induce cardiotonic effects mediated by a selective inhibition of the Na(+)/K(+)
Burgos Morón, Estefanía +5 more
core +3 more sources
"Oxygen sensing" by Na,K-ATPase: These miraculous thiols [PDF]
, 2016 Control over the Na,K-ATPase function plays a central role in adaptation of the organisms to hypoxic and anoxic conditions. As the enzyme itself does not possess O2 binding sites its "oxygen-sensitivity" is mediated by a variety of redox-sensitive ...
Bogdanova, Anna +2 more
core +2 more sources
Cooperative and Competitive Biases for Multi-Agent Reinforcement Learning [PDF]
arXiv, 2021 Training a multi-agent reinforcement learning (MARL) algorithm is more challenging than training a single-agent reinforcement learning algorithm, because the result of a multi-agent task strongly depends on the complex interactions among agents and their interactions with a stochastic and dynamic environment.
arxiv
Fact-based Agent modeling for Multi-Agent Reinforcement Learning [PDF]
arXiv, 2023 In multi-agent systems, agents need to interact and collaborate with other agents in environments. Agent modeling is crucial to facilitate agent interactions and make adaptive cooperation strategies. However, it is challenging for agents to model the beliefs, behaviors, and intentions of other agents in non-stationary environment where all agent ...
arxiv
Calcium sensitizers: What have we learned over the last 25years? [PDF]
, 2018 K
Papp, Gy. Julius +2 more
core +1 more source
MDL 17,043 therapy in severe congestive heart failure: Characterization of the early and late hemodynamic, pharmacokinetic, hormonal and clinical response [PDF]
, 1985 MDL 17,043, an agent with both inotropic and vasodilator properties, was evaluated in the treatment of chronic severe heart failure. The early and late hemodynamic, hormonal, pharmacokinetic and clinical responses to oral MDL 17,043 were studied in 20 ...
Generalovich, Thomas +4 more
core +1 more source
Inhibitory effect of combinations of digoxin and endogenous cardiotonic steroids on Na+/K+-ATPase activity in human kidney membrane preparation [PDF]
, 2011 AimsCardiac glycosides have been extensively used in the treatment of congestive heart failure for more than 200years. Recently, cardenolides and bufadienolides were isolated from mammalian tissue and are considered as a new class of steroidal hormones ...
Cunha-Filho, Geraldino +5 more
core +1 more source
Resuscitation after experimental cardiac arrest. [PDF]
, 1953 Thesis (M.A.)--Boston ...
Salvador, Richard Anthony
core +1 more source
Acta Ophthalmologica, EarlyView.Abstract Purpose Red blood cell (RBC) transfusions are believed to be associated with retinopathy of prematurity (ROP), but the underlying mechanism is not fully understood, partly due to the lack of information on RBC transfusion timing. The aim was to determine the association between the timing and amount of RBC transfusions and the development and ...
Salma El Emrani +9 more
wiley +1 more source
Cooperative Heterogeneous Deep Reinforcement Learning [PDF]
arXiv, 2020 Numerous deep reinforcement learning agents have been proposed, and each of them has its strengths and flaws. In this work, we present a Cooperative Heterogeneous Deep Reinforcement Learning (CHDRL) framework that can learn a policy by integrating the advantages of heterogeneous agents.
arxiv