Results 91 to 100 of about 3,242,366 (329)

Lipid Toxicity in the Cardiovascular-Kidney-Metabolic Syndrome (CKMS)

Biomedicines
Recent studies of Cardiovascular-Kidney-Metabolic Syndrome (CKMS) indicate that elevated concentrations of derivatives of phospholipids (ceramide, sphingosine), oxidized LDL, and lipoproteins (a, b) are toxic to kidney and heart function. Energy production for renal proximal tubule resorption of critical fuels and electrolytes is required for ...
John A. D’Elia, Larry A. Weinrauch
openaire   +3 more sources

A Novel Pak1 Activator Ameliorates ER Stress for HFpEF Therapy

Advanced Science, EarlyView.
Chronic metabolic stress is a major contributor to HFpEF progression. Under prolonged metabolic stress, Pak1 activity becomes impaired, contributing to disrupted ER proteostasis, cardiomyocyte apoptosis, fibrosis, and diastolic dysfunction. Mechanistically, Pak1 overexpression activates the ERK1/2–MNK1–eIF4E signaling axis, promotes translational ...
Honglin Xu, Hongyuan Zhang, Tayyiba Azam, Susanne S. Hille, Yingjuan Liu, Min Zi, Jiaqing Lang, He Yu, Yujia Cao, Bernard D. Keavney, Tamer M. A. Mohamed, Jessica M. Miller, Riham R. E. Abouleisa, Ming Xu, Elizabeth J. Cartwright, Oliver J. Müller, Ming Lei, Xin Wang   +17 more
wiley   +1 more source

Longitudinal trajectories of serum uric acid and incident cardiovascular–kidney–metabolic syndrome components: Outcome-specific mediating role of adiposity in a large community-based cohort

Journal of International Medical Research
Objective Serum uric acid links cardiovascular, kidney, and metabolic health; however, its role within the cardiovascular–kidney–metabolic syndrome framework is poorly understood, especially its long-term dynamics.
Xiaoqing Chen, Jianhua Gu, Ye Xu, Fang Yuan   +3 more
doaj   +1 more source

A holistic approach to managing cardio-kidney metabolic syndrome: insights and recommendations from the Italian perspective

Frontiers in Cardiovascular Medicine
Cardio-kidney metabolic (CKM) syndrome represents a complex and circular interplay of cardiovascular, renal, and metabolic dysfunctions, significantly contributing to global morbidity and mortality.
Massimo Iacoviello, Mauro Gori, Giuseppe Grandaliano, Giuseppe Grandaliano, Roberto Minutolo, Dario Pitocco, Roberto Trevisan, Roberto Trevisan   +7 more
doaj   +1 more source

Inflammation in cardiovascular-kidney-metabolic syndrome: key roles and underlying mechanisms–a comprehensive review

Molecular and Cellular Biochemistry
Cardiovascular-Kidney-Metabolic (CKM) syndrome, a newly defined systemic disorder, is characterized by the pathological interplay among diabetes, chronic kidney disease (CKD), and cardiovascular disease (CVD).
Zhen Xu, Shuo Yang, Yuan Tan, Qian Zhang, He Wang, Jingjin Tao, Qi Liu, Qing-Chen Wang, Weimin Feng, Zhongxin Li, Chong Wang, Li-Yan Cui   +11 more
semanticscholar   +1 more source

Dysregulation of the MACF1‐Rab14/KIF16B‐FGFR Vesicular Trafficking Axis Skews MSC Lineage Commitment in Glucocorticoid‐Induced Osteoporosis

Advanced Science, EarlyView.
Under normal conditions, MACF1 interacts with Rab14 and facilitates KIF16B‐mediated FGFR vesicle trafficking along microtubules to the plasma membrane, thereby supporting BMSC differentiation. In contrast, chronic GC exposure suppresses MACF1 expression, disrupting this transport and causing intracellular FGFR retention, which blunts osteogenic ...
Peihong Su, Ye Tian, Fan Zhao, Jing Li, Suryaji Patil, Chunyu Zhu, Yujia Tian, Junrong Wang, Jiating Liu, Aoqi Xiang, Hua Guan, Lusha Zhang, Xiaochang Chen, Airong Qian, Qi Yu   +14 more
wiley   +1 more source

CARDIAL-MS (CArdio-Renal-DIAbetes-Liver-Metabolic Syndrome): a new proposition for an integrated multisystem metabolic disease

Diabetology & Metabolic Syndrome
Background Metabolic Syndrome—a constellation of insulin resistance, cardiovascular risk factors as hyperglycemia, hypertension, and dyslipidemia, and systemic metabolic dysfunction—may be driven by dysregulation of adipose tissue, which manifests as ...
Amélio F. Godoy-Matos, Cynthia Melissa Valério, Wellington S. Silva Júnior, João Marcello de Araujo-Neto, Andrei C. Sposito, José Hermógenes Rocco Suassuna   +5 more
doaj   +1 more source

Metabolic Memory in Cardiovascular Disease: Encoding, Propagation, and Therapeutic Targeting

Advanced Science, EarlyView.
Cardiovascular risk often persists after metabolic abnormalities are corrected. This conceptual Review frames such persistence as metabolic memory, encoded through a narrowing therapeutic window from reversible marks to irreversible damage, with continuous input from peripheral organs.
Cheng Cheng, Minghui Tang, Zhaobo Zhang, Ruoyi Qu, Jianfei Pei, Tian Liu, Siyao Qu, Shilong You, Shenshen Cui, Wenke Wang, Rui Zhao, Yingxian Sun, Naijin Zhang   +12 more
wiley   +1 more source

The Metabolic Syndrome Predicts Cardiovascular Events: Results of a 13-Year Follow-Up in Initially Healthy 58-Year-Old Men

, 2012
Background: The metabolic syndrome is a global health problem and is associated with subsequent development of cardiovascular disease (CVD). However, data are scarce concerning prospective association of the syndrome and CVD in populations free of ...
Bergström, Göran,, Schmidt, Caroline,
core   +1 more source

Effects of maternal high fat diet and pharmacological intervention on the developmental origins of metabolic & cardiovascular disease

, 2011
A high fat (HF) diet leads to hypercholesterolemia and predisposes the individual to developing cardiovascular disease (CVD). We hypothesised that mother‘s HF diet before and during pregnancy and lactation can also influence predisposition to CVD in ...
Elahi, Maqsood M.
core   +1 more source