Results 91 to 100 of about 3,440,112 (288)

MASLD and the Cardiovascular-Kidney-Liver-Metabolic syndrome

Obesity is an alarmingly growing global epidemic strongly associated with type 2 diabetes, cardiovascular disease, metabolic syndrome, and chronic kidney disease. Metabolic dysfunction-associated steatotic liver disease (MASLD) is considered an important
Angeliki M Angelidi, Christos S Mantzoros, Dimitri P Mikhailidis, George Jacob, Michail Kokkorakis, Konstantinos Stefanakis, Chrysoula Boutari   +6 more
core   +1 more source

Paediatric development of radiopharmaceutical imaging agents and radioligand therapeutics

British Journal of Clinical Pharmacology, EarlyView.
Abstract This review focuses on the development of radiopharmaceutical imaging agents and radioligand therapeutics for paediatric use. Nuclear medicine plays an important role in the diagnosis and treatment of various childhood conditions, including cancers, infections and brain disorders.
Justin L. Hay, Amandine Manon, Hunter Stephens, S. Y. Amy Cheung, Bart de Keizer, Erik T. te Beek   +5 more
wiley   +1 more source

Role of Sodium-Glucose Transport Protein-2 Inhibitors in Renal Protection: A Narrative Review from the Cardiovascular-Kidney-Metabolic Interconnection

Drug Design, Development and Therapy
Nan Ye, Hong Cheng Department of Nephrology, Beijing Anzhen Hospital, Capital Medical University, Beijing, People’s Republic of ChinaCorrespondence: Hong Cheng, Department of Nephrology, Beijing Anzhen Hospital, Capital Medical University, No.
Ye N, Cheng H
doaj  

Finerenone: Evidence for Benefit in Early Stages of Cardiovascular-Kidney-Metabolic Syndrome

Cardiorenal Medicine
Background: Cardiovascular-kidney-metabolic (CKM) syndrome is a recently introduced concept that links chronic kidney disease (CKD), cardiovascular disease, and metabolic risk factors such as obesity or diabetes mellitus (DM). The use of eGFR
Diego Francisco Márquez, Alberto Ortiz, Daniel González-Moreno, Luis Miguel Ruilope, Gema Ruiz-Hurtado   +4 more
doaj   +1 more source

Safety outcomes of antidiabetic medications: A comprehensive review of the EU summaries of product characteristics and international clinical practice guidelines

British Journal of Clinical Pharmacology, EarlyView.
Aims Information on the safety profile of antidiabetic medications is essential for informed treatment decisions in type 2 diabetes mellitus. Although this information is available in regulatory documents of individual drugs, a comprehensive overview across all approved antidiabetics is lacking.
David Liang, Daniala L. Weir, Safana Thevasahayam, Vera H. M. Deneer, Arno Siebes, Helga Gardarsdottir   +5 more
wiley   +1 more source

Beyond glycemic control: cardiovascular and kidney benefits of GLP-1 receptor agonists and the dual GIP/GLP-1 receptor agonist tirzepatide: a narrative review

Frontiers in Endocrinology
Cardiovascular-kidney-metabolic (CKM) syndrome reflects the complex interplay among cardiovascular disease, chronic kidney disease, type 2 diabetes, and obesity. GLP-1 receptor agonists and tirzepatide have emerged as important therapeutic options within
Filip Kierzkowski, Wiktoria Skrzypek, Wiesław Bryl, Anna Paczkowska, Karolina Hoffmann   +4 more
doaj   +1 more source

Understanding the Role of Sex Hormones in Cardiovascular Kidney Metabolic Syndrome: Toward Personalized Therapeutic Approaches [PDF]

Cardiovascular kidney metabolic syndrome; Chronic kidney disease; Sex hormoneSíndrome metabólico renal cardiovascular; Enfermedad renal crónica; Hormonas sexualesSíndrome metabòlica renal cardiovascular; Malaltia renal crònica; Hormones ...
Mustafa Guldan, Abdel-Rahman, Sama, Maria José Soler, Güldan, Mustafa, Soler, María José, Laşin Ozbek, Özbek, Laşin, Mehmet Kanbay, Covic, Andreea, Sama Mahmoud Abdel-Rahman, Unlu, Selen, Gaipov, Abduzhappar, Selen Unlu, Andreea Covic, Abduzhappar Gaipov, Adrian Covic, Kanbay, Mehmet, Unlu, S., Covic, Adrian, AbdelRahman, Sama Mahmoud   +19 more
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Transgenic amplification of glucocorticoid action in adipose tissue causes high blood pressure in mice [PDF]

, 2003
Obesity is closely associated with the metabolic syndrome, a combination of disorders including insulin resistance, diabetes, dyslipidemia, and hypertension.
Kenyon, C J, Joel K. Elmquist, Elmquist, Joel K., Flier, Jeffrey S., Jonathan R. Seckl, Yamamoto, H, Yamamoto, Hiroshi, Mullins, J J, John J. Mullins, Shinyama, H, Shinyama, Hiroshi, Masuzaki, H, Nicholas M. Morton, Janice M. Paterson, Paterson, Janice M., Sharp, M G F, Jeffrey S. Flier, Seckl, J R, Sharp, Matthew G. F., Masuzaki, Hiroaki, Paterson, J M, Matthew G.F. Sharp, Seckl, Jonathan R., Hiroshi Yamamoto, Morton, Nicholas M., Stewart Fleming, Elmquist, J K, Morton, N M, Hiroaki Masuzaki, Flier, J S, Mullins, John J., Fleming, S, Hiroshi Shinyama, Fleming, Stewart, Kenyon, Christopher J., Christopher J. Kenyon   +35 more
core   +1 more source

Hypertension in obesity: A focus on individualized pharmacotherapy and the role of body composition, on behalf of the European Society of Hypertension Working Group on Diabetes and Metabolic Risk Factors and Working Group on Lifestyle, Cardiovascular Pharmacotherapy and Adherence

British Journal of Clinical Pharmacology, EarlyView.
Hypertension in obesity represents a major global health challenge, closely linked to the global epidemics of obesity, type 2 diabetes and metabolic dysfunction. Excess adiposity contributes to elevated blood pressure through multiple, interrelated mechanisms, including activation of the renin–angiotensin–aldosterone system, sympathetic nervous system ...
Christina Antza, Andrej Belancic, Jens Jordan, Alberto Esteban, Anna Oliveras, Ryan McNally, Panagiota Anyfanti, Jorie Versmissen, María S. Fernández‐Alfonso, Vasilios Kotsis, Thomas Weber, Alexandre Persu, Reinhold Kreutz   +12 more
wiley   +1 more source

Metabolic syndrome and kidney dysfunction: emerging molecular and cellular mechanisms at the metabolic–renal interface

Frontiers in Endocrinology
Metabolic syndrome and chronic kidney disease frequently coexist, acting synergistically to amplify the risk of adverse cardiovascular and renal outcomes.
William R. Marshall, William R. Marshall, Darren Green, Darren Green, Smeeta Sinha, Smeeta Sinha, Philip A. Kalra, Philip A. Kalra   +7 more
doaj   +1 more source