Results 101 to 110 of about 3,242,366 (329)

Joint association of estimated glucose disposal rate and systemic inflammation response index with mortality in cardiovascular-kidney-metabolic syndrome stage 0–3: a nationwide prospective cohort study

Cardiovascular Diabetology
The Cardiovascular-Kidney-Metabolic (CKM) syndrome underscores the complex interactions among metabolic disorders, kidney disease, and cardiovascular conditions.
Yuwen Chen, Wenbin Lian, Lun-Zhe Wu, An’an Huang, De-Lian Zhang, Bingchen Liu, Yuangang Qiu, Qu-Cheng Wei   +7 more
semanticscholar   +1 more source

Cardiovascular-kidney-metabolic syndrome (literature review)

Inter Collegas
Background. In recent years, the importance of the concept of cardiovascular-kidney-metabolic health has been increasingly emphasized, reflecting the close pathogenetic and clinical relationship between cardiovascular disease, renal dysfunction, and metabolic health in general.
T.V. Ashcheulova, N.M. Herasymchuk, T.M. Ambrosova, O.A. Kochubiei, U.S. Herasymchuk   +4 more
openaire   +1 more source

Targeting the NR1D1–IGF2BP2–V‐ATPase Axis With Hybrid Nanovesicles Restores Macrophage Rhythms to Reverse Sepsis‐Induced Immunosuppression

Advanced Science, EarlyView.
Sepsis disrupts immune‐cell rhythms and weakens bacterial clearance. Biomimetic nanovesicles combining erythrocyte and inflammation‐activated macrophage membranes deliver siNR1D1 to dysfunctional macrophages, restoring the NR1D1–IGF2BP2–V‐ATPase pathway, circadian regulation, phagolysosomal acidification, and antimicrobial defense.
Lang Chen, Wenyi Lin, Lang Jiang, Xuehui Gao, Chenyan Yu, Jili Han, Zhenping Liu, Xuefeng Li, Mei He, Chang Li, Qilan Li, Chaoying Song, Jiqian Xu, You Shang   +13 more
wiley   +1 more source

Intestinal peroxisome proliferator‐activated receptor α‐fatty acid‐binding protein 1 axis modulates nonalcoholic steatohepatitis

Hepatology, EarlyView., 2022
Abstract Background and Aims Peroxisome proliferator‐activated receptor α (PPARα) regulates fatty acid transport and catabolism in liver. However, the role of intestinal PPARα in lipid homeostasis is largely unknown. Here, intestinal PPARα was examined for its modulation of obesity and NASH. Approach and Results Intestinal PPARα was activated and fatty
Tingting Yan, Yuhong Luo, Nana Yan, Keisuke Hamada, Nan Zhao, Yangliu Xia, Ping Wang, Changdong Zhao, Dan Qi, Shoumei Yang, Lulu Sun, Jie Cai, Qiong Wang, Changtao Jiang, Oksana Gavrilova, Kristopher W. Krausz, Daxesh P. Patel, Xiaoting Yu, Xuan Wu, Haiping Hao, Weiwei Liu, Aijuan Qu, Frank J. Gonzalez   +22 more
wiley   +1 more source

Association between the triglyceride glucose-body mass index and future cardiovascular disease risk in a population with Cardiovascular-Kidney-Metabolic syndrome stage 0–3: a nationwide prospective cohort study

Cardiovascular Diabetology
The American Heart Association (AHA) has recently introduced the concept of Cardiovascular-Kidney-Metabolic (CKM) syndrome, which is the result of an increasing emphasis on the interplay of metabolic, renal and cardiovascular diseases (CVD). Furthermore,
Weipeng Li, Chaonan Shen, Weiya Kong, Xiaohui Zhou, Hui-Min Fan, Yu-Zhen Zhang, Zhongmin Liu, Liang Zheng   +7 more
semanticscholar   +1 more source

ROS‐Responsive Nanoparticle Delivery of Dexmedetomidine Protects the Gut Vascular Barrier After Intestinal Ischemia/Reperfusion via the HDAC‐H3K27ac‐TCF4 Axis

Advanced Science, EarlyView.
A low dose of dexmedetomidine, delivered by ROS‐responsive nanoparticles, preferentially accumulates in the ischemic intestine and restores gut vascular barrier integrity after ischemia/reperfusion injury. This nanoparticle‐based strategy prevents bacterial translocation and liver damage without cardiorespiratory side effects, working through HDAC ...
Hu‐Fei Zhang, Jian‐Tong Shen, Hua‐Hua Zhang, Si‐Qi Gao, Ji‐Ao Wang, Yue‐Ling Wang, Mei‐Ling Li, Zi‐Meng Liu, Yi‐Nan Zhang, Yan Li, Xu‐Yu Zhang   +10 more
wiley   +1 more source

Factors associated with cardiovascular events after simultaneous liver–kidney transplant from the US Multicenter Simultaneous Liver–Kidney Transplant Consortium

Hepatology Communications, EarlyView., 2022
Abstract Cardiovascular disease is a leading complication after both liver and kidney transplantation. Factors associated with and rates of cardiovascular events (CVEs) after simultaneous liver–kidney transplant (SLKT) are unknown. This was a retrospective cohort study of adult SLKT recipients between 2002 and 2017 at six centers in six United Network ...
Jennifer Jo, Gonzalo Crespo, Dyanna Gregory, Jasmine Sinha, Jiaheng Xie, Min Zhang, John Magee, Pranab Barman, Yuval A. Patel, Aaron Schluger, Kara Walters, Scott Biggins, Natalia Filipek, Giuseppe Cullaro, Randi Wong, Jennifer C. Lai, Gabriel J. Perreault, Elizabeth C. Verna, Pratima Sharma, Lisa B. VanWagner   +19 more
wiley   +1 more source

Oxidative Status and Lipid Profile in Metabolic Syndrome: Gender Differences

, 2010
Background: Metabolic syndrome is associated with cardiovascular disease and oxidative stress. The aim of this study was to investigate the differences of novel oxidative stress parameters and lipid profiles in men and women with metabolic ...
Uzunhasan, Isil, Baskurt, Murat, Yigit, Zerrin, Kaya, Aysem, Ozkan, Alev, ATAOGLU, Esra, Okcun, Baris   +6 more
core   +1 more source

Genetic variants in lipid metabolism are independently associated with multiple features of the metabolic syndrome [PDF]

, 2011
Background Our objective was to find single nucleotide polymorphisms (SNPs), within transcriptional pathways of glucose and lipid metabolism, which are related to multiple features of the metabolic syndrome (MetS).
Boer, J.M., Dollé Martijn ET, Boer Jolanda MA, Feskens Edith JM, Martijn ET Dollé, Edith JM Feskens, Imholz, S., Feskens, E.J.M., Sandra Imholz, Povel, C.M., Cécile M Povel, Jolanda MA Boer, Imholz Sandra, Povel Cécile M, Dolle, M.E.   +14 more
core   +1 more source

Challenges and knowledge gaps in sex differences in cardio–kidney–metabolic syndrome across the lifespan

Biology of Sex Differences
Cardiovascular–kidney–metabolic (CKM) syndrome represents a continuum of interrelated adiposity, insulin resistance, cardiovascular disease, kidney dysfunction, and metabolic disturbances that evolve across the lifespan.
Aline M. A. de Souza, Alexandra Kautzky-Willer, Damian G. Romero, Licy L. Yanes Cardozo, Sofia B. Ahmed, Samar Rezq   +5 more
doaj   +1 more source