Results 111 to 120 of about 3,242,366 (329)

Prevalence of Cardiovascular-Kidney-Metabolic Syndrome Stages by Social Determinants of Health

JAMA Network Open
Key Points Question Does the prevalence of cardiovascular-kidney-metabolic (CKM) syndrome stages vary by social determinants of health (SDOH) in US adults?
Rui-Xin Zhu, Ran Wang, Jing-Jing He, Lang-Run Wang, Hui-Yu Chen, Xiao-Kang Niu, You Sun, Yiran Guan, Yifan Gong, Li-Wei Zhang, Peng An, Ke-Ji Li, Fa-Zheng Ren, Wei-Li Xu, Jie Guo   +14 more
semanticscholar   +1 more source

Aspirin‐Derived Salicyl‐CoA Drives Histone Lysine Salicylation Regulated by CBP and SIRT2

Advanced Science, EarlyView.
Aspirin‐derived salicyl‐CoA serves as a previously unrecognized acyl donor for protein lysine salicylation. This study identifies histone lysine salicylation as a reversible epigenetic modification regulated by CBP and SIRT2, expanding the biochemical actions of aspirin beyond its canonical acetylation‐dependent mechanisms and providing a new framework
Facai Zhang, Chuanzan Zhou, Jiaoyan He, Pengpeng Huang, Rong Zhang, Huan Hu, Meng Jiao, Linyi Hu, Feng Liu, Xiaolong Qi, Xiang He, Yunkai Yang, Y Eugene Chinn, Dechao Feng, Dahong Zhang, Qi Zhang   +15 more
wiley   +1 more source

Gender-related and Age-related Disparities in Prevalence of the Cardiovascular-Kidney-Metabolic Syndrome Among US Adults From 1999-2020: An Analysis of the NHANES Survey

Kidney Medicine
Rationale & Objectives: The cardiovascular-kidney-metabolic (CKM) syndrome is defined as the intricate interplay among metabolic risks, chronic kidney disease (CKD) and the cardiovascular system. The deteriorating CKM syndrome contributes to untimely
Zhejia Tian, Samira Soltani, Johann Bauersachs, Kai M. Schmidt-Ott, Anette Melk, Bernhard M.W. Schmidt   +5 more
doaj   +1 more source

Role of oxidative balance score in staging and mortality risk of cardiovascular-kidney-metabolic syndrome: Insights from traditional and machine learning approaches

Redox Biology
Objectives To evaluate the roles of oxidative balance score (OBS) in staging and mortality risk of cardiovascular-kidney-metabolic syndrome (CKM). Methods Data of this study were from the National Health and Nutrition Examination Survey 1999–2018.
Yang Chen, Shuang Wu, Hongyu Liu, Z. Zhong, T. Bucci, Yimeng Wang, Man-Lin Zhao, Yang Liu, Zhengkun Yang, Y. Gue, G. McDowell, Bi Huang, G. Lip   +12 more
semanticscholar   +1 more source

Chinese Expert Consensus on the Clinical Application of Finerenone in Geriatric Comorbidities

AGING MEDICINE, EarlyView.
Mineralocorticoid receptor (MR) overactivation drives inflammation, oxidative stress, and fibrosis in the heart, kidneys, and vasculature, leading to cardiorenal dysfunction. MR signaling promotes hypertrophy, remodeling, and injury through pathways like oxidative stress and inflammation, resulting in vascular stiffness and progressive organ damage ...
Xiaoming Wang, Cuntai Zhang
wiley   +1 more source

Expert Consensus on the Management of Obesity in Older Adults (2026 Edition)

AGING MEDICINE, EarlyView.
This graphical abstract summarizes a safety‐first framework for managing obesity in older adults, with attention to age, functional status, comorbidities, and sarcopenia risk. Key assessments include BMI, waist measures, body fat percentage, skeletal muscle mass, and comprehensive geriatric evaluation. Management prioritizes reducing visceral fat while
Qi Pan, Lixin Guo
wiley   +1 more source

Risk Factor Management for Metabolic Syndrome

, 2021
Metabolic syndrome is a cluster of physiological and metabolic abnormalities such as central obesity, insulin resistance, hypertension, dyslipidemia, high triglycerides, and low HDL.
Yao-Wei, Tsai
core  

Finerenone: Evidence for Benefit in Early Stages of Cardiovascular-Kidney-Metabolic Syndrome

Cardiorenal Medicine
Background: Cardiovascular-kidney-metabolic (CKM) syndrome is a recently introduced concept that links chronic kidney disease (CKD), cardiovascular disease, and metabolic risk factors such as obesity or diabetes mellitus (DM). The use of eGFR
Diego Francisco Márquez, Alberto Ortiz, Daniel González-Moreno, Luis Miguel Ruilope, Gema Ruiz-Hurtado   +4 more
doaj   +1 more source

A Novel NR3C1 Frameshift Variant Associated With Familial Glucocorticoid Resistance Syndrome: An Integrated Analysis of Steroid Profiling and Structural Modeling

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Glucocorticoid resistance syndrome (GRS) is a rare hereditary disorder caused by pathogenic variants in NR3C1, characterized by marked phenotypic heterogeneity and frequent misdiagnosis as primary aldosteronism or subclinical Cushing's syndrome.
Sufang Yun, Zhifeng Zhu, Fengye Zhou, Ying Liu, Chunfang Liang, Haitao Ju, Lin Lu, Zhaoli Yan   +7 more
wiley   +1 more source

Metabolic Syndrome and Associated Kidney Disease

, 2012
With the rise in the incidence of childhood obesity, it is increasingly ­evident that the burden of chronic kidney disease (CKD) has increased proportionately and has its origins in early life.
Wacharee Seeherunvong, Carolyn L. Abitbol, Seeherunvong, Wacharee, Abitbol, Carolyn L   +3 more
core   +1 more source