Results 81 to 90 of about 4,308,682 (335)

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

open access: yesFEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka   +11 more
wiley   +1 more source

Mark Savickas’ theory as an inspiration for professional counselling aimed at adults enhanced with the application of Diagnostic and Simulation Games Method

open access: yesRocznik Andragogiczny, 2016
In case of adult learners, the process of professional counselling, diagnosing of professional predispositions or providing support for learners in their professional career construction frequently requires the application of different methods and ...
Przemysław Ziółkowski
doaj   +1 more source

Occupation Profile: Librarians, October 5, 2017 [PDF]

open access: yes, 2017
Construct, erect, install or repair structures and fixtures made of wood, such as concrete forms; building frameworks, including partitions, joists, studding, and rafters; and wood stairways, window and door frames, and hardwood floors.

core  

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Balancing employee needs, project requirements and organisational priorities in team deployment [PDF]

open access: yes, 2006
The 'people and performance' model asserts that performance is a sum of employee ability, motivation and opportunity (AMO). Despite extensive evidence of this people-performance link within manufacturing and many service sectors, studies within the ...
Andrew R. J. Dainty   +20 more
core   +1 more source

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

open access: yesMolecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian   +10 more
wiley   +1 more source

Career advancement of the professional women in the UK construction industry: Career success factors [PDF]

open access: yes
The issue regarding the lack of women in the UK construction industry has become more prominent for some time, attracting government and industry wide attention due to this potential skill shortage facing the industry.
Amaratunga, Dilanthi   +2 more
core  

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

open access: yesMolecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath   +13 more
wiley   +1 more source

The impact of training and development on career advancement of professional women in the UK construction industry [PDF]

open access: yes
The redressing the gender imbalance in the UK construction industry has been emphasised on numerous occasions and many researchers have identified that women can contribute in an immense way towards the construction industry development.
Amaratunga, Dilanthi, Fernando, G.
core  

Occupation Profile:Sheet Metal Workers, October 6, 2017 [PDF]

open access: yes, 2017
Fabricate, assemble, install and repair sheet metal products and equipment, such as ducts, control boxes, drainpipes, and furnace casings. Work may involve any of the following: setting up and operating fabricating machines to cut, bend, and ...

core  

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