Results 21 to 30 of about 20,666 (222)

Carnitine palmitoyltransferase II deficiency and post-COVID vaccination rhabdomyolysis

QJM : monthly journal of the Association of Physicians, 2021
Carnitine palmitoyltransferase II (CPT II) deficiency is a disorder affecting fatty acid oxidation. The myopathic form of the condition is the most common among adults and manifests itself with a high serum creatine kinase (CK) concentration. Triggers of
A. Tan, K. Stepien, S. Narayana
semanticscholar   +1 more source

ATL I, Acts as a SIRT6 Activator to Alleviate Hepatic Steatosis in Mice via Suppression of NLRP3 Inflammasome Formation

Pharmaceuticals, 2022
Accumulating evidence has highlighted that sirtuin-6 (SIRT6) plays an important role in hepatic gluconeogenesis and lipogenesis. We aim to investigate the underlying mechanisms and pharmacological interventions of SIRT6 on hepatic steatosis treatment ...
Danli Kong, Zhenhua Mai, Yongze Chen, Ling Luo, Hao Liu, Le Zhao, Ruixian Huang, Shuang Wang, Rong Chen, Hao Zhou, Hao Chen, Jingjing Zhang, Haibing Yu, Yuanlin Ding   +13 more
doaj   +1 more source

Carnitine Palmitoyltransferase 1 Regulates Prostate Cancer Growth under Hypoxia

Cancers, 2021
Simple Summary Cancer cell survival in hypoxia areas, with low oxygen and food supply as well as abundant waste material, is critical to their aggressiveness and associated with disease relapse and mortality.
Leslimar Rios-Colon, Pawan Kumar, Susy Kim, Mitu Sharma, Yixin Su, Ashish Kumar, Sangeeta Singh, Nalexus Stocks, Liang Liu, Molishree Joshi, Isabel R Schlaepfer, Deepak Kumar, G. Deep   +12 more
semanticscholar   +1 more source

Simultaneously targeting SOAT1 and CPT1A ameliorates hepatocellular carcinoma by disrupting lipid homeostasis

Cell Death Discovery, 2021
Lipid homeostasis plays a fundamental role in the development of hepatocellular carcinoma (HCC). However, the mechanisms that regulate lipid homeostasis to avoid lipotoxicity in HCC remain elusive.
Meiling Ren, Huanji Xu, Hongwei Xia, Qiulin Tang, Feng Bi   +4 more
doaj   +1 more source

Chlorogenic acid improves glucose tolerance, lipid metabolism, inflammation and microbiota composition in diabetic db/db mice

Frontiers in Endocrinology, 2022
IntroductionChronic and acute chlorogenic acid (CGA) can improve glucose tolerance (GT) and insulin sensitivity (IS). However, whether acute administration of CGA has beneficial effects on hepatic lipid metabolism and cecal microbiota composition remains
Yongwang Yan, Qing Li, Ling Shen, Kangxiao Guo, Kangxiao Guo, Xu Zhou   +5 more
doaj   +1 more source

Stevioside Enhances the Anti-Adipogenic Effect and β-Oxidation by Activating AMPK in 3T3-L1 Cells and Epididymal Adipose Tissues of db/db Mice

Cells, 2022
Stevioside, the primary sweetener in stevia, is a glycoside with numerous beneficial biological activities. However, its anti-adipogenic effects on tissue differentiation and adipose tissues remain to be thoroughly investigated.
Miey Park, Hana Baek, Jin-Young Han, Hae-Jeung Lee   +3 more
doaj   +1 more source

Clinical and literature review of a case of myopathic form of carnitine palmitoyltransferase Ⅱ deficiency [PDF]

精准医学杂志
Objective To explore the correlations of genotype and phenotype of myopathic form of carnitine palmitoyltransferase Ⅱ (CPT Ⅱ) deficiency and to improve the clinical understanding of the disease.
LU Guangshuang, XIA Mingnong, CHENG Yun, HU Jie, LI Wenbo, ZHANG Fan, YANG Wu
doaj   +1 more source

Polygonum multiflorum Thunb. Hot Water Extract Reverses High-Fat Diet-Induced Lipid Metabolism of White and Brown Adipose Tissues in Obese Mice

Plants, 2021
The purpose of the present study was to determine whether an anti-obesity effect of a Polygonum multiflorum Thunb. hot water extract (PW) was involved in the lipid metabolism of white adipose tissue (WAT) and brown adipose tissue (BAT) in high-fat diet ...
Ra-Yeong Choi, Mi-Kyung Lee
doaj   +1 more source

Muscle Carnitine Palmitoyltransferase II (CPT II) Deficiency: A Conceptual Approach

Molecules, 2020
Carnitine palmitoyltransferase (CPT) catalyzes the transfer of long- and medium-chain fatty acids from cytoplasm into mitochondria, where oxidation of fatty acids takes place.
P. Joshi, S. Zierz
semanticscholar   +1 more source

Dietary moderately oxidized oil induces expression of fibroblast growth factor 21 in the liver of pigs [PDF]

, 2012
BACKGROUND: Fibroblast growth factor 21 (FGF21), whose expression is induced by peroxisome proliferator-activated receptor alpha (PPARalpha), has been recently identified as a novel metabolic regulator which plays a crucial role in glucose homeostasis ...
Eder, Klaus, Ringseis, Robert, Varady, Juliane   +2 more
core   +2 more sources