Results 81 to 90 of about 8,146 (141)

CIDEC Restricts Liver Regeneration by Disturbing Lipid Droplet Triglyceride Turnover

Advanced Science, Volume 13, Issue 3, 14 January 2026.
This study identifies CIDEC, an lipid droplet (LD)‐fusion associated protein upregulated by CREBH during early regeneration, as a negative regulator of liver regeneration through its unexpected role in sequestering triglyceride (TG) within LDs. CIDEC depletion reduces LD size, mobilizes LD‐stored TG, enhances TG catabolism and free fatty acid (FFA ...
Feng Ouyang, Yining Li, Zixuan Zhang, Fangfang Sun, Yihong Shi, Qian Gui, Da Luo, Changyong Hu, Hang Su, Kaiqi Shen, Lu Gao, Hui Yang, Feng‐Jung Chen, Rong Li, Tong‐Jin Zhao, Peng Li, Tian‐Shu Yang   +16 more
wiley   +1 more source

Mechanistic Insights and Therapeutic Potential of Small Nucleolar RNA Host Genes in the Carcinogenesis of Hepatocellular Carcinoma

Cancer Medicine, Volume 15, Issue 1, January 2026.
ABSTRACT Background Hepatocellular carcinoma (HCC) is one of the major factors endangering human health due to its poor prognosis, resulting from difficulties in early diagnosis and lack of effective treatment measures. Long non‐coding RNAs (lncRNAs), which are RNA molecules that do not translate into proteins, play essential roles in various tumor ...
Jiajia Luo, Zhangxiu Liao, Shuangxia Zhang   +2 more
wiley   +1 more source

Dietary corn starch dose-dependently enhances intestinal and hepatic health in largemouth bass (Micropterus salmoides)

Aquaculture Reports
The study aimed to investigate starch-induced hepatobiliary syndrome in juvenile largemouth bass. Six isonitrogenous diets (Con, CoS20, CoS40, CoS60, CoS80, CoS100) with corn starch substituting 0 %, 20 %, 40 %, 60 %, 80 %, and 100 % of wheat starch ...
Godfred Boateng Agyenim, Fred Bissih, Derrick Asare, Beiping Tan, Shiwei Xie, Junming Deng   +5 more
doaj   +1 more source

Partial Replacement of Maltodextrin With Galactose in Post‐Weaning Diets of Mice Alters Body Composition and Energy Metabolism in Early‐Life and Programs Hepatic Igf1 Expression in Later‐Life

Molecular Nutrition &Food Research, Volume 70, Issue 1, January 2026.
Galactose‐containing post‐weaning diets given for 3 weeks decreased body weight and changed energy metabolism compared to a maltodextrin‐enriched control diet in the early life of mice. After following 9 weeks of a high‐fat diet intervention, the mice fed in the early life the galactose‐containing diets had no obvious nutritional programming effects ...
Peixin Sun, Maryam Rakhshandehroo, Melissa Bekkenkamp‐Grovenstein, Lidewij Schipper, Jaap Keijer, Evert M. van Schothorst   +5 more
wiley   +1 more source

Chirality‐Directed Strategy to Overcome Tumor Resistance to Cuproptosis and Enhance Cuproptosis‐Immunotherapy

Small Structures, Volume 7, Issue 1, January 2026.
Chirality‐directed strategy designed by copper‐based nanoregulator (Cu‐D‐Car@HA) to potentiate collaborative cuproptosis‐immunotherapy by overcoming tumor resistance to cuproptosis highlights a materials‐based method for superior cuproptosis‐immunotherapy.
Hao Zhou, Xiaoyang Zhang, Yu‐Zhang Wang, Shi‐Man Zhang, Hong Chen, Xiao Yan, Chi‐Hui Yang, Wei‐Hai Chen, Xian‐Zheng Zhang   +8 more
wiley   +1 more source

Bioenergetics and lipid metabolism in Alzheimer's disease: From cell biology to systemic health

Journal of Internal Medicine, Volume 299, Issue 1, Page 20-43, January 2026.
Abstract Alzheimer's disease (AD) is a complex neurodegenerative disorder characterized by progressive cognitive decline. Although amyloid‐β and tau pathologies remain central to our understanding of AD, growing evidence suggests that disrupted lipid metabolism and impaired bioenergetics are closely linked to these hallmark features. Genetic, lipidomic
Silvia Maioli, Ivan Nalvarte, Maria Ankarcrona, Marianne Schultzberg, Kristen L. Zuloaga, Julen Goikolea, Pieter Jelle Visser, Bart De Strooper, Bengt Winblad, Paola Pizzo, Pete A. Williams, Patricia Rodriguez‐Rodriguez, Luana Naia   +12 more
wiley   +1 more source

The Role of Innate Lymphoid Cells in the Pathogenesis of Hepatic Echinococcosis: A Literature Review

Parasite Immunology, Volume 48, Issue 1, January 2026.
ABSTRACT Hepatic echinococcosis (HE), a major zoonotic disease, remains endemic in pastoral regions of Western China, where its incidence is closely linked to geographical, livestock and sanitary conditions. The disease presents a significant clinical challenge due to the complexity of host–parasite interactions and a high recurrence rate. To date, the
Wei Ma, Dian Wang, Chuanchuan Liu, Haining Fan   +3 more
wiley   +1 more source

Bavachin ameliorates cisplatin-induced nephrotoxicity by enhancing mitochondrial β-oxidation and lipid metabolism through MFN2

Molecular Medicine
Background Cisplatin-induced nephrotoxicity is a critical adverse reaction that restricts the clinical utilization of cisplatin. Alterations in fatty acid metabolism have been associated with the pathogenesis of cisplatin-induced nephrotoxicity, yet the ...
Shilu Luo, Ming Yang, Na Jiang, Chenrui Li, Yan Liu, Lin Sun   +5 more
doaj   +1 more source

The multifaceted roles of ketones in physiology

Experimental Physiology, Volume 111, Issue 1, Page 1-13, 1 January 2026.
Abstract The production of ketones, referred to as ketogenesis, plays an essential role in maintaining energy homeostasis during prolonged fasting/starvation, which primarily stems from its ability to serve as a fuel source to support neuronal ATP production, thereby limiting muscle wasting. Over the years, the field has come to appreciate that ketones
Seyed Amirhossein Tabatabaei Dakhili, Kunyan Yang, Magnus J. Stenlund, John R. Ussher   +3 more
wiley   +1 more source

The Influence of Eicosapentaenoic Acid on Macrobrachium rosenbergii Broodstock: Ovarian Development, Antioxidant Status, and Lipid Metabolism

Aquaculture Nutrition, Volume 2026, Issue 1, 2026.
Lipids are essential for crustacean reproduction, supporting broodstock growth and ovarian development. However, studies of n‐3 highly unsaturated fatty acids (HUFAs), particularly eicosapentaenoic acid (EPA), on the growth and ovarian development of prawn broodstock remain limited.
Yuxin Sun, Hao Chen, Ling Gan, Jiao Liu, Yonghui Jian, Qiyou Xu, Zhili Ding, Noah Esmaeili   +7 more
wiley   +1 more source