Carnosine Prevents Aβ-Induced Oxidative Stress and Inflammation in Microglial Cells: A Key Role of TGF-β1 [PDF]
Cells, 2019 Carnosine (β-alanyl-L-histidine), a dipeptide, is an endogenous antioxidant widely distributed in excitable tissues like muscles and the brain. Carnosine is involved in cellular defense mechanisms against oxidative stress, including the inhibition ...
Giuseppe Caruso +2 more
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Carnosine inhibits the proliferation of human gastric cancer SGC-7901 cells through both of the mitochondrial respiration and glycolysis pathways. [PDF]
PLoS ONE, 2014 Carnosine, a naturally occurring dipeptide, has been recently demonstrated to possess anti-tumor activity. However, its underlying mechanism is unclear.
Yao Shen +6 more
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Skeletal muscle analysis of cancer patients reveals a potential role for carnosine in muscle wasting [PDF]
Journal of Cachexia, Sarcopenia and Muscle, 2023 Background Muscle wasting during cancer cachexia is mediated by protein degradation via autophagy and ubiquitin‐linked proteolysis. These processes are sensitive to changes in intracellular pH ([pH]i) and reactive oxygen species, which in skeletal muscle
Dheeraj Kumar Posa +10 more
doaj +2 more sources
Carnosine, Small but Mighty—Prospect of Use as Functional Ingredient for Functional Food Formulation
Antioxidants, 2021 Carnosine is a dipeptide synthesized in the body from β-alanine and L-histidine. It is found in high concentrations in the brain, muscle, and gastrointestinal tissues of humans and is present in all vertebrates.
Ivana Jukic +2 more
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Effect of histidine and carnosine on haemoglobin recovery in anaemia induced-kidney damage and iron-loading mouse models [PDF]
Amino AcidsHistidine and carnosine can form complexes with divalent metal ions such as Fe2+, potentially providing stability to intracellular labile iron.
Mayra Vera-Aviles +4 more
doaj +2 more sources
Carnosine as a protective metabolic mediator in inflammatory lung injury by inhibiting macrophage infiltration and M1-like polarization. [PDF]
Front PharmacolRuan L +7 more
europepmc +3 more sources
Use of Carnosine for Oxidative Stress Reduction in Different Pathologies [PDF]
Oxidative Medicine and Cellular Longevity, 2016 V. D. Prokopieva +3 more
exaly +2 more sources
Sensitized Photo-Oxidation of Anserine and Carnosine: Laser Flash Photolysis and CIDNP Study. [PDF]
ACS Phys Chem AuMorozova OB +3 more
europepmc +2 more sources
Dietary Carnosine Supplementation in Healthy Human Volunteers: A Safety, Tolerability, Plasma and Brain Concentration Study. [PDF]
NutrientsAli AN +9 more
europepmc +3 more sources
Enhanced mitochondrial activity reshapes a gut microbiota profile that delays NASH progression
Hepatology, EarlyView., 2022 Improved mitochondrial activity, due to the lack of methylation‐controlled J protein (MCJ), creates a specific microbiota signature that when transferred through cecal microbiota transplantation delays NASH progression by restoring the gut‐liver axis and enhancing hepatic fatty acid oxidation.
María Juárez‐Fernández +18 more
wiley +1 more source