Results 11 to 20 of about 22,312 (304)

Carnosine quenches the reactive carbonyl acrolein in the central nervous system and attenuates autoimmune neuroinflammation

Journal of Neuroinflammation, 2021
Background Multiple sclerosis (MS) is a chronic autoimmune disease driven by sustained inflammation in the central nervous system. One of the pathological hallmarks of MS is extensive free radical production. However, the subsequent generation, potential
Jan Spaas, Wouter M. A. Franssen, Charly Keytsman, Laura Blancquaert, Tim Vanmierlo, Jeroen Bogie, Bieke Broux, Niels Hellings, Jack van Horssen, Dheeraj Kumar Posa, David Hoetker, Shahid P. Baba, Wim Derave, Bert O. Eijnde   +13 more
doaj   +2 more sources

The Therapeutic Potential of Novel Carnosine Formulations: Perspectives for Drug Development

Pharmaceuticals, 2023
Carnosine (beta-alanyl-L-histidine) is an endogenous dipeptide synthesized via the activity of the ATP-dependent enzyme carnosine synthetase 1 and can be found at a very high concentration in tissues with a high metabolic rate, including muscles (up to ...
Angela Bonaccorso, Anna Privitera, Margherita Grasso, Sonya Salamone, Claudia Carbone, Rosario Pignatello, Teresa Musumeci, Filippo Caraci, Giuseppe Caruso   +8 more
doaj   +2 more sources

Context‐Specific Metabolic Alterations in HPRT1 Knockout Cells Within a 3D Culture System [PDF]

Cancer Medicine, Volume 14, Issue 23, December 2025.
Cancer metabolism studies in 2D culture models often overlook the in vivo complexity. We found that HPRT1 knockout suppressed cell proliferation in 3D and in vivo, but had minimal effect in 2D. Metabolomic analysis also revealed that HPRT1 knockout increased carnosine production via the β‐alanine pathway in 3D cultures. ABSTRACT Background Cancer cells
Sho Tabata, Ichiro Fujimoto, Tomoyoshi Soga, Hideki Makinoshima   +3 more
wiley   +2 more sources

L-carnosine Attenuates Bleomycin-Induced Oxidative Stress via NFκB Pathway in the Pathogenesis of Pulmonary Fibrosis

Antioxidants, 2022
Idiopathic Pulmonary fibrosis (IPF), a chronic interstitial lung disease, has pulmonary manifestations clinically characterized by collagen deposition, epithelial cell injury, and a decline in lung function.
Jaehyun Park, Jimin Jang, Sang-Ryul Cha, Hyosin Baek, Jooyeon Lee, Seok-Ho Hong, Hyang-Ah Lee, Tae-Jin Lee, Se-Ran Yang   +8 more
doaj   +2 more sources

Carnosine in health and disease [PDF]

European Journal of Sport Science, 2018
AbstractCarnosine was originally discovered in skeletal muscle, where it exists in larger amounts than in other tissues. The majority of research into the physiological roles of carnosine have been conducted on skeletal muscle. Given this and the potential for muscle carnosine content to be increased with supplementation, there is now a large body of ...
Artioli, GG, Sale, C, Jones, RL
openaire   +4 more sources

Anti-stress effects of carnosine on restraint-evoked immunocompromise in mice through spleen lymphocyte number maintenance. [PDF]

PLoS ONE, 2012
Carnosine (β-alanyl-L-histidine), a naturally occurring dipeptide, has been characterized as a putative neurotransmitter and serves as a reservoir for brain histamine, which could act on histaminergic neurons system to relieve stress-induced damages ...
Yi-Fang Li, Rong-Rong He, Bun Tsoi, Xiao-Di Li, Wei-Xi Li, Keiichi Abe, Hiroshi Kurihara   +6 more
doaj   +3 more sources

Modulation of Mitochondrial Function and Autophagy Mediates Carnosine Neuroprotection Against Ischemic Brain Damage [PDF]

Stroke, 2014
Background and Purpose—Despite the rapidly increasing global burden of ischemic stroke, no therapeutic options for neuroprotection against stroke currently exist.
Akram, M., Bae, O-N., Baek, S-H., Kim, E-S., Kim, K-A., Majid, A., Noh, A. R., Shin, Y-J., Yu, S. W.   +8 more
core   +4 more sources

Development of L-carnosine functionalized iron oxide nanoparticles loaded with dexamethasone for simultaneous therapeutic potential of blood brain barrier crossing and ischemic stroke treatment

Drug Delivery, 2021
The development of suitable drug delivery carriers is significant in biomedical applications to improve the therapeutic efficiency. Recent progress in nanotechnological fields, paved the way for the formulation of variety of drug carriers.
Xianfeng Lu, Yaohui Zhang, Lixiang Wang, Guichen Li, Jianyuan Gao, Ying Wang   +5 more
semanticscholar   +3 more sources

L-Carnosine Stimulation of Coenzyme Q10 Biosynthesis Promotes Improved Mitochondrial Function and Decreases Hepatic Steatosis in Diabetic Conditions

Antioxidants, 2021
Mitochondrial dysfunction in type 2 diabetes leads to oxidative stress, which drives disease progression and diabetes complications. L-carnosine, an endogenous dipeptide, improves metabolic control, wound healing and kidney function in animal models of ...
Cheng Schwank-Xu, Elisabete Forsberg, Magnus Bentinger, Allan Zhao, Ishrath Ansurudeen, Gustav Dallner, Sergiu-Bogdan Catrina, Kerstin Brismar, Michael Tekle   +8 more
doaj   +2 more sources

Modulation of Pro-Oxidant and Pro-Inflammatory Activities of M1 Macrophages by the Natural Dipeptide Carnosine

International Journal of Molecular Sciences, 2020
Carnosine is a natural endogenous dipeptide widely distributed in mammalian tissues, existing at particularly high concentrations in the muscles and brain and possesses well-characterized antioxidant and anti-inflammatory activities. In an in vitro model
C. Fresta, A. Fidilio, Giacomo Lazzarino, N. Musso, M. Grasso, S. Merlo, A. M. Amorini, C. Bucolo, B. Tavazzi, G. Lazzarino, S. Lunte, F. Caraci, G. Caruso   +12 more
semanticscholar   +3 more sources