Results 21 to 30 of about 9,220 (223)

Carnosine Potentiates Doxorubicin-Induced Cytotoxicity in Resistant NCI/ADR-RES Cells by Inhibiting P-Glycoprotein—In Silico and In Vitro Evidence

Molecules, 2022
The activity of the P-glycoprotein (P-gp) transporter encoded by the ABCB1 gene confers resistance to anticancer drugs and contributes to cancer-related mortality and morbidity.
Mohamed A. Morsy, Mahmoud Kandeel, Ahmed R. N. Ibrahim, Seham A. Abdel-Gaber, Shery Jacob, Katharigatta N. Venugopala, Pottathil Shinu, Mahmoud El-Daly   +7 more
doaj   +1 more source

Thermodynamic and voltammetric study on carnosine and ferrocenyl-carnosine

Dalton Transactions, 2023
An electroactive carnosine derivative (ferrocenyl-carnosine, FcCAR (L)) was synthesized and its complexing and sensing properties were evaluated; it was found to be promising for the electrochemical detection of Hg2+and Pb2+in an aqueous environment.
Chiara Abate, Anna Piperno, Alex Fragoso, Ottavia Giuffrè, Antonino Mazzaglia, Angela Scala, Claudia Foti   +6 more
openaire   +3 more sources

Carnosine quenches the reactive carbonyl acrolein in the central nervous system and attenuates autoimmune neuroinflammation

Journal of Neuroinflammation, 2021
Background Multiple sclerosis (MS) is a chronic autoimmune disease driven by sustained inflammation in the central nervous system. One of the pathological hallmarks of MS is extensive free radical production. However, the subsequent generation, potential
Jan Spaas, Wouter M. A. Franssen, Charly Keytsman, Laura Blancquaert, Tim Vanmierlo, Jeroen Bogie, Bieke Broux, Niels Hellings, Jack van Horssen, Dheeraj Kumar Posa, David Hoetker, Shahid P. Baba, Wim Derave, Bert O. Eijnde   +13 more
doaj   +1 more source

CARNOSINE-LOADED ORAL NIOSOMES AMELIORATE HIGH-FRUCTOSE-INDUCED METABOLIC SYNDROME IN RATS VIA MODULATION OF SIRT1, A METABOLIC MASTER SWITCH

Slovenian Veterinary Research, 2023
Metabolic syndrome is a crucial health challenge, and the available therapeutic agents are still not effective. Carnosine, a cytoplasmic dipeptide, is a potent anti-glycation, anti-oxidant, anti-inflammatory and chelating agent.
Amany I Ahmed, Nada Y. Nasr, Mahmoud A. Said, Reham H. Alattar, Khalifa El-Dawy   +4 more
doaj   +1 more source

Regulation of mitochondrial function and energy metabolism: A primary mechanism of cytoprotection provided by carnosine [PDF]

Trends in Pharmaceutical Sciences, 2018
Carnosine is an abundantly found dipeptide present in different tissues. Several pharmacological properties have been attributed to carnosine. On the other hand, the precise mechanism of cytoprotection provided by carnosine remains obscure.
Reza Heidari, Vahid Ghanbarinejad, Mohammad Mehdi Ommati, Akram Jamshidzadeh, Hossein Niknahad   +4 more
doaj   +3 more sources

Carnosine and bone (Review)

Molecular Medicine Reports, 2022
Carnosine is a vital endogenous dipeptide that has anti‑inflammatory, antiaging, anti‑crosslinking, antitumor and immune regulatory effects. Numerous cell and animal model studies have proved that carnosine and its compounds promote the proliferation and differentiation of osteoblasts, inhibit osteoclasts and protect chondrocytes.
Yang, Hao, Hou, Xiaoli, Xing, Lei, Tian, Faming   +3 more
openaire   +2 more sources

Characterisation of intracellular molecular mechanisms modulated by carnosine in porcine myoblasts under basal and oxidative stress conditions.

PLoS ONE, 2020
Carnosine is a naturally occurring histidine-containing dipeptide present at high concentration in mammalian skeletal muscles. Carnosine was shown to affect muscle contraction, prevent the accumulation of oxidative metabolism by-products and act as an ...
Marie-France Palin, Jérôme Lapointe, Claude Gariépy, Danièle Beaudry, Claudia Kalbe   +4 more
doaj   +2 more sources

Evaluation of Antidiabetic and Antioxidant Activities of L-carnosine using Enzyme Inhibition and Free Radical Scavenging Assays: An In-vitro Study [PDF]

Journal of Clinical and Diagnostic Research, 2023
Introduction: Diabetes is a chronic disease that causes dysfunction of various organs and tissues resulting in end organ damage and premature mortality. Oxidative stress is a main factor of diabetic complications.
D Malathy, D Anusha, K Karthika, K Punnagai   +3 more
doaj   +1 more source

Effect of dietary carnosine during in vitro digestion of a burger meal combo model including ascorbic acid as an antioxidant and fructose as a pro-oxidant. [PDF]

J Food Sci
Li YY, Yaylayan V, Palin MF, Ngapo TM, Cliche S, Gagnon F, Gariépy C.   +6 more
europepmc   +3 more sources

The neuroprotective efficacy of carnosine-containing nanoliposomes and S-trolox-carnosine under oxidative stress conditions in vitro and in vivo

Анналы клинической и экспериментальной неврологии, 2017
We investigated the protective effect of carnosine (carnosine-containing nanoliposomes and newly synthesized S-trolox-carnosine) in experiments in vivo on a model of acute hypobaric hypoxia in rodents and in vitro on neuronal cultures under oxidative ...
T. N. Fedorova, S. L. Stvolinskiy, O. I. Kulikova, E. V. Konovalova, I. S. Levacheva, O. - Samsonova, U. - Bakovskiy   +6 more
doaj   +1 more source