Results 31 to 40 of about 9,220 (223)

The Therapeutic Potential of Carnosine/Anserine Supplementation against Cognitive Decline: A Systematic Review with Meta-Analysis

Biomedicines, 2021
Carnosine is a natural occurring endogenous dipeptide that was proposed as an anti-aging agent more than 20 years ago. Carnosine can be found at low millimolar concentrations at brain level and different preclinical studies have demonstrated its ...
Giuseppe Caruso, Justyna Godos, Sabrina Castellano, Agnieszka Micek, Paolo Murabito, Fabio Galvano, Raffaele Ferri, Giuseppe Grosso, Filippo Caraci   +8 more
doaj   +1 more source

Carnosine Catalyzes the Formation of the Oligo/Polymeric Products of Methylglyoxal

Cellular Physiology and Biochemistry, 2018
Background/Aims: Reactive dicarbonyl compounds, such as methylglyoxal (MG), contribute to diabetic complications. MG-scavenging capacities of carnosine and anserine, which have been shown to mitigate diabetic nephropathy, were evaluated in vitro and in ...
Tim Weigand, Benjamin Singler, Thomas Fleming, Peter Nawroth, Karel D. Klika, Christian Thiel, Hans Baelde, Sven F. Garbade, Andreas H. Wagner, Markus Hecker, Benito A. Yard, Albert Amberger, Johannes Zschocke, Claus P. Schmitt, Verena Peters   +14 more
doaj   +1 more source

Improved Satellite Cell Proliferation Induced by L-Carnosine Benefits Muscle Growth of Pigs in Part through Activation of the Akt/mTOR/S6K Signaling Pathway

Agriculture, 2022
(1) Background: L-carnosine (β-alanyl-L-histidine), a natural dipeptide, exists at relatively high concentrations in skeletal muscles, and has been shown to protect cells from adverse conditions due to its antioxidant, anti-aging, anti-glycation, and ...
Yaojun Liu, Wenqiang Shen, Tao Liu, Rainer Mosenthin, Yinghui Bao, Peng Chen, Wenbo Hao, Lihong Zhao, Jianyun Zhang, Cheng Ji, Qiugang Ma   +10 more
doaj   +1 more source

Exercise and β-alanine supplementation on carnosine-acrolein adduct in skeletal muscle

Redox Biology, 2018
Previous studies have demonstrated that exercise results in reactive aldehyde production and that β-alanine supplementation increases carnosine content in skeletal muscle.
Victor H. Carvalho, Ana H.S. Oliveira, Luana F. de Oliveira, Rafael P. da Silva, Paolo Di Mascio, Bruno Gualano, Guilherme G. Artioli, Marisa H.G. Medeiros   +7 more
doaj   +1 more source

Carnosine modulates Aβ-induced transcriptional aberrations in murine microglial cells. [PDF]

Curr Res Pharmacol Drug Discov
Rivi V, Carota G, Tascedda F, Blom JMC, Caraci F, Benatti C, Caruso G.   +6 more
europepmc   +2 more sources

L-Carnosine Stimulation of Coenzyme Q10 Biosynthesis Promotes Improved Mitochondrial Function and Decreases Hepatic Steatosis in Diabetic Conditions

Antioxidants, 2021
Mitochondrial dysfunction in type 2 diabetes leads to oxidative stress, which drives disease progression and diabetes complications. L-carnosine, an endogenous dipeptide, improves metabolic control, wound healing and kidney function in animal models of ...
Cheng Schwank-Xu, Elisabete Forsberg, Magnus Bentinger, Allan Zhao, Ishrath Ansurudeen, Gustav Dallner, Sergiu-Bogdan Catrina, Kerstin Brismar, Michael Tekle   +8 more
doaj   +1 more source

Carnosine Supplementation Enhances Post Ischemic Hind Limb Revascularization

Frontiers in Physiology, 2019
High (millimolar) concentrations of the histidine containing dipeptide – carnosine (β-alanine-L-histidine) are present in the skeletal muscle. The dipeptide has been shown to buffer intracellular pH, chelate transition metals, and scavenge lipid ...
Adjoa A. Boakye, Deqing Zhang, Deqing Zhang, Luping Guo, Luping Guo, Yuting Zheng, Yuting Zheng, David Hoetker, David Hoetker, Jingjing Zhao, Jingjing Zhao, Dheeraj Kumar Posa, Dheeraj Kumar Posa, Chin K. Ng, Huaiyu Zheng, Amit Kumar, Vijay Kumar, Michael F. Wempe, Aruni Bhatnagar, Aruni Bhatnagar, Daniel J. Conklin, Daniel J. Conklin, Shahid P. Baba, Shahid P. Baba   +23 more
doaj   +1 more source

Anti-stress effects of carnosine on restraint-evoked immunocompromise in mice through spleen lymphocyte number maintenance. [PDF]

PLoS ONE, 2012
Carnosine (β-alanyl-L-histidine), a naturally occurring dipeptide, has been characterized as a putative neurotransmitter and serves as a reservoir for brain histamine, which could act on histaminergic neurons system to relieve stress-induced damages ...
Yi-Fang Li, Rong-Rong He, Bun Tsoi, Xiao-Di Li, Wei-Xi Li, Keiichi Abe, Hiroshi Kurihara   +6 more
doaj   +1 more source

Carnosine retards tumor growth in vivo in an NIH3T3-HER2/neu mouse model

Molecular Cancer, 2010
Background It was previously demonstrated that the dipeptide carnosine inhibits growth of cultured cells isolated from patients with malignant glioma.
Meixensberger Jürgen, Gebhardt Rolf, Hengstler Jan, Hermes Matthias, Geiger Kathrin D, Fuchs Beate, Zemitzsch Nadine, Renner Christof, Gaunitz Frank   +8 more
doaj   +1 more source

Carnosine attenuates vascular smooth muscle cells calcification through mTOR signaling pathway

Aging Medicine, 2020
Objective Vascular calcification is prevalent in the aging population, as we know that arterial calcification is associated with aging. Recent studies have demonstrated that carnosine, a naturally occurring dipeptide, performs the treatment of aging ...
Yi Huang, Jinli Wang, Mandi Luo, Dan Yan, Cuntai Zhang   +4 more
doaj   +1 more source