Results 41 to 50 of about 22,312 (304)
Drug Delivery, 2022 Purpose Thermosensitive in situ gels have been around for decades but only a few have been translated into ophthalmic pharmaceuticals. The aim of this study was to combine the thermo-gelling polymer poloxamer 407 and mucoadhesive polymers chitosan (CS ...
Zeinab Fathalla +5 more
semanticscholar +1 more source
Physiological Roles of Carnosine in Myocardial Function and Health
Advances in Nutrition, 2022 Carnosine is a pleiotropic histidine-containing dipeptide synthesized from β-alanine and l-histidine, with the intact dipeptide and constituent amino acids being available from the diet.
Jade Creighton +7 more
semanticscholar +1 more source
PLoS ONE, 2020 Carnosine is a naturally occurring histidine-containing dipeptide present at high concentration in mammalian skeletal muscles. Carnosine was shown to affect muscle contraction, prevent the accumulation of oxidative metabolism by-products and act as an ...
Marie-France Palin +4 more
doaj +2 more sources
Neuroprotective Effect of Carnosine Is Mediated by Insulin-Degrading Enzyme
ACS Chemical Neuroscience, 2022 l-Carnosine is an endogenous dipeptide that has high potential for therapeutic purposes, being an antioxidant with metal chelating, anti-aggregating, anti-inflammatory, and neuroprotective properties.
Alessia Distefano +7 more
semanticscholar +1 more source
Carnosine and cancer: a perspective [PDF]
Amino Acids, 2012 The application of carnosine in medicine has been discussed since several years, but many claims of therapeutic effects have not been substantiated by rigorous experimental examination. In the present perspective, a possible use of carnosine as an anti-neoplastic therapeutic, especially for the treatment of malignant brain tumours such as glioblastoma ...
Frank, Gaunitz, Alan R, Hipkiss
openaire +2 more sources
Evaluation of Antidiabetic and Antioxidant Activities of L-carnosine using Enzyme Inhibition and Free Radical Scavenging Assays: An In-vitro Study [PDF]
Journal of Clinical and Diagnostic Research, 2023 Introduction: Diabetes is a chronic disease that causes dysfunction of various organs and tissues resulting in end organ damage and premature mortality. Oxidative stress is a main factor of diabetic complications.
D Malathy +3 more
doaj +1 more source
Muscle carnosine metabolism and β-alanine supplementation in relation to exercise and training [PDF]
, 2010 Carnosine is a dipeptide with a high concentration in mammalian skeletal muscle. It is synthesized by carnosine synthase from the amino acids L-histidine and beta-alanine, of which the latter is the rate-limiting precursor, and degraded by carnosinase ...
Baguet, Audrey +3 more
core +2 more sources
International Journal of Molecular Sciences, 2022 Carnosine is an endogenous β-alanyl-L-histidine dipeptide endowed with antioxidant and carbonyl scavenger properties, which is able to significantly prevent the visible signs of aging and photoaging. To investigate the mechanism of action of carnosine on
G. Aiello +6 more
semanticscholar +1 more source
International Society of Sports Nutrition position stand: beta-alanine [PDF]
, 2015 Position statement: The International Society of Sports Nutrition (ISSN) provides an objective and critical review of the mechanisms and use of beta-alanine supplementation.
Antonio, J +13 more
core +4 more sources
Molecules, 2022 Different drug classes such as antineoplastic drugs (anthracyclines, cyclophosphamide, 5-fluorouracil, taxanes, tyrosine kinase inhibitors), antiretroviral drugs, antipsychotic, and immunosuppressant drugs are known to induce cardiotoxic and neurotoxic ...
Giuseppe Caruso +6 more
semanticscholar +1 more source