Results 1 to 10 of about 369,909 (184)

Engraftment of allogeneic iPS cell-derived cartilage organoid in a primate model of articular cartilage defect

Nature Communications, 2023
Induced pluripotent stem cells (iPSCs) are a promising resource for allogeneic cartilage transplantation to treat articular cartilage defects that do not heal spontaneously and often progress to debilitating conditions, such as osteoarthritis.
Kengo Abe, A. Yamashita, Miho Morioka, N. Horike, Yoshiaki Takei, Saeko Koyamatsu, K. Okita, Shuichi Matsuda, N. Tsumaki   +8 more
semanticscholar   +1 more source

SOX9 keeps growth plates and articular cartilage healthy by inhibiting chondrocyte dedifferentiation/osteoblastic redifferentiation

Proceedings of the National Academy of Sciences of the United States of America, 2021
Significance Cartilage is essential in vertebrate development and adulthood. Cartilage growth plates ensure skeletal growth until closing at puberty, and articular cartilage ensures lifelong structural and functional integrity of joints.
A. Haseeb, R. Kc, M. Angelozzi, Charles de Charleroy, Danielle Rux, R. Tower, L. Yao, Renata Pellegrino da Silva, M. Pacifici, L. Qin, V. Lefebvre   +10 more
semanticscholar   +1 more source

Strategies for Articular Cartilage Repair and Regeneration

Frontiers in Bioengineering and Biotechnology, 2021
Articular cartilage is an avascular tissue, with limited ability to repair and self-renew. Defects in articular cartilage can induce debilitating degenerative joint diseases such as osteoarthritis.
Yanxi Liu, Karan M. Shah, Jian Luo
semanticscholar   +1 more source

Mechanical stress determines the configuration of TGFβ activation in articular cartilage

Nature Communications, 2021
Our incomplete understanding of osteoarthritis (OA) pathogenesis has significantly hindered the development of disease-modifying therapy. The functional relationship between subchondral bone (SB) and articular cartilage (AC) is unclear.
G. Zhen, Qiaoyue Guo, YuSheng Li, Chuanlong Wu, Shouan Zhu, Ruomei Wang, X. Guo, Byoung Choul Kim, Jessie Huang, Y. Hu, Yang Dan, M. Wan, T. Ha, S. An, Xu Cao   +14 more
semanticscholar   +1 more source

Comparison between articular chondrocytes and mesenchymal stromal cells for the production of articular cartilage implants

Frontiers in Bioengineering and Biotechnology, 2023
Focal lesions of articular cartilage give rise to pain and reduced joint function and may, if left untreated, lead to osteoarthritis. Implantation of in vitro generated, scaffold-free autologous cartilage discs may represent the best treatment option ...
Nadine Frerker, Tommy A. Karlsen, Maria Stensland, Tuula A. Nyman, Tuula A. Nyman, Simon Rayner, Simon Rayner, Simon Rayner, Jan E. Brinchmann, Jan E. Brinchmann   +9 more
doaj   +1 more source

Ultrafast, tough, and adhesive hydrogel based on hybrid photocrosslinking for articular cartilage repair in water-filled arthroscopy

Science Advances, 2021
A photocrosslinking hydrogel technique facilitates articular cartilage repair in minimally invasive surgery.
Yujie Hua, Huitang Xia, Litao Jia, Jinzhong Zhao, Dandan Zhao, Xiaoyu Yan, Yiqing Zhang, Shengjian Tang, Guangdong Zhou, Linyong Zhu, Qiuning Lin   +10 more
semanticscholar   +1 more source

Main and Minor Types of Collagens in the Articular Cartilage: The Role of Collagens in Repair Tissue Evaluation in Chondral Defects

International Journal of Molecular Sciences, 2021
Several collagen subtypes have been identified in hyaline articular cartilage. The main and most abundant collagens are type II, IX and XI collagens.
Lourdes Alcaide-Ruggiero, V. Molina-Hernández, M. Granados, J. M. Domínguez   +3 more
semanticscholar   +1 more source

Vitrification of particulated articular cartilage via calculated protocols

npj Regenerative Medicine, 2021
Preserving viable articular cartilage is a promising approach to address the shortage of graft tissue and enable the clinical repair of articular cartilage defects in articulating joints, such as the knee, ankle, and hip.
Kezhou Wu, Nadia Shardt, Leila Laouar, Janet A. W. Elliott, Nadr M. Jomha   +4 more
doaj   +1 more source

CCN family member 2/connective tissue growth factor (CCN2/CTGF) has anti-aging effects that protect articular cartilage from age-related degenerative changes. [PDF]

PLoS ONE, 2013
To examine the role of connective tissue growth factor CCN2/CTGF (CCN2) in the maintenance of the articular cartilaginous phenotype, we analyzed knee joints from aging transgenic mice (TG) overexpressing CCN2 driven by the Col2a1 promoter.
Shinsuke Itoh, Takako Hattori, Nao Tomita, Eriko Aoyama, Yasutaka Yutani, Takashi Yamashiro, Masaharu Takigawa   +6 more
doaj   +1 more source

Acellular cartilage matrix biomimetic scaffold with immediate enrichment of autologous bone marrow mononuclear cells to repair articular cartilage defects

Materials Today Bio, 2022
Functional repair of articular cartilage defects is always a great challenge in joint surgery clinically. Tissue engineering strategies that combine autologous cell implantation with three-dimensional scaffolds have proven effective for repairing ...
Litao Jia, Peiling Zhang, Zheng Ci, Xiaoyan Hao, Baoshuai Bai, Wei Zhang, Haiyue Jiang, Guangdong Zhou   +7 more
doaj   +1 more source