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Mesenchymal Stem Cells for Treating Articular Cartilage Defects and Osteoarthritis
Cell Transplantation, 2015 Articular cartilage damage and osteoarthritis are the most common joint diseases. Joints are prone to damage caused by sports injuries or aging, and such damage regularly progresses to more serious joint disorders, including osteoarthritis, which is a ...
Yu Wang +4 more
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Nature Communications, 2023 Induced pluripotent stem cells (iPSCs) are a promising resource for allogeneic cartilage transplantation to treat articular cartilage defects that do not heal spontaneously and often progress to debilitating conditions, such as osteoarthritis.
Kengo Abe +8 more
semanticscholar +1 more source
Proceedings of the National Academy of Sciences of the United States of America, 2021 Significance Cartilage is essential in vertebrate development and adulthood. Cartilage growth plates ensure skeletal growth until closing at puberty, and articular cartilage ensures lifelong structural and functional integrity of joints.
A. Haseeb +10 more
semanticscholar +1 more source
Strategies for Articular Cartilage Repair and Regeneration
Frontiers in Bioengineering and Biotechnology, 2021 Articular cartilage is an avascular tissue, with limited ability to repair and self-renew. Defects in articular cartilage can induce debilitating degenerative joint diseases such as osteoarthritis.
Yanxi Liu, Karan M. Shah, Jian Luo
semanticscholar +1 more source
Science Advances, 2021 A photocrosslinking hydrogel technique facilitates articular cartilage repair in minimally invasive surgery.
Yujie Hua +10 more
semanticscholar +1 more source
Mechanical stress determines the configuration of TGFβ activation in articular cartilage
Nature Communications, 2021 Our incomplete understanding of osteoarthritis (OA) pathogenesis has significantly hindered the development of disease-modifying therapy. The functional relationship between subchondral bone (SB) and articular cartilage (AC) is unclear.
G. Zhen +14 more
semanticscholar +1 more source
Frontiers in Bioengineering and Biotechnology, 2023 Focal lesions of articular cartilage give rise to pain and reduced joint function and may, if left untreated, lead to osteoarthritis. Implantation of in vitro generated, scaffold-free autologous cartilage discs may represent the best treatment option ...
Nadine Frerker +9 more
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International Journal of Molecular Sciences, 2021 Several collagen subtypes have been identified in hyaline articular cartilage. The main and most abundant collagens are type II, IX and XI collagens.
Lourdes Alcaide-Ruggiero +3 more
semanticscholar +1 more source
Vitrification of particulated articular cartilage via calculated protocols
npj Regenerative Medicine, 2021 Preserving viable articular cartilage is a promising approach to address the shortage of graft tissue and enable the clinical repair of articular cartilage defects in articulating joints, such as the knee, ankle, and hip.
Kezhou Wu +4 more
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CCN family member 2/connective tissue growth factor (CCN2/CTGF) has anti-aging effects that protect articular cartilage from age-related degenerative changes. [PDF]
PLoS ONE, 2013 To examine the role of connective tissue growth factor CCN2/CTGF (CCN2) in the maintenance of the articular cartilaginous phenotype, we analyzed knee joints from aging transgenic mice (TG) overexpressing CCN2 driven by the Col2a1 promoter.
Shinsuke Itoh +6 more
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