Histological Analysis of Failed Cartilage Repair after Marrow Stimulation for the Treatment of Large Cartilage Defect in Medial Compartmental Osteoarthritis of the Knee [PDF]
, 2013 Bone marrow-stimulating techniques such as microfracture and subchondral drilling are valuable treatments for full-thickness cartilage defects. However, marrow stimulation-derived reparative tissues are not histologically well-documented in human ...
Abe, Nobuhiro +5 more
core +1 more source
Inhibition of NADPH Oxidases Prevents the Development of Osteoarthritis
Antioxidants, 2022 Increased oxidative stress in osteoarthritis (OA) cartilage mediates catabolic signal transduction leading to extracellular matrix degradation and chondrocyte apoptosis.
Jin Han +3 more
doaj +1 more source
The Role of Senescence-Associated Secretory Phenotype in Bone Loss
Frontiers in Cell and Developmental Biology, 2022 As the population of most nations have a large proportion of older individuals, there is an increase in the prevalence of osteoporosis. Consequently, scientists have focused their attention on the pathogenic mechanisms of osteoporosis.
Runjiu Zhu +10 more
doaj +1 more source
Imaging of nuclear magnetic resonance spin–lattice relaxation activation energy in cartilage [PDF]
, 2017 Samples of human and bovine cartilage have been examined using magnetic resonance imaging to determine the proton nuclear magnetic resonance spin–lattice relaxation time, T1, as a function of depth within through the cartilage tissue.
Binks, D.A. +6 more
core +2 more sources
Scientific Reports, 2017 Cartilage tissue is avascular and hypoxic which regulates chondrocyte phenotype via stabilization of HIFs. Here, we investigated the role of hypoxia and HIFs in regulation of Rho and canonical Wnt signaling in chondrocytes.
Ece Öztürk +4 more
doaj +1 more source
Development of a peptide-siRNA nanocomplex targeting NF- κB for efficient cartilage delivery [PDF]
, 2019 Delivery of therapeutic small interfering RNAs (siRNAs) in an effective dose to articular cartilage is very challenging as the cartilage dense extracellular matrix renders the chondrocytes inaccessible, even to intra-articular injections. Herein, we used
Akk, Antonina +7 more
core +3 more sources
Extracellular Vesicles: A Potential Biomarker for Quick Identification of Infectious Osteomyelitis
Frontiers in Cellular and Infection Microbiology, 2020 Effective management of infectious osteomyelitis relies on timely microorganism identification and appropriate antibiotic therapy. Extracellular vesicles (EVs) carry protein and genetic information accumulated rapidly in the circulation upon infection ...
Songyun Deng +14 more
doaj +1 more source
Correlation of Patient Symptoms With Labral and Articular Cartilage Damage in Femoroacetabular Impingement. [PDF]
, 2018 BackgroundFemoroacetabular impingement (FAI) can lead to labral and articular cartilage injuries as well as early osteoarthritis of the hip. Currently, the association of patient symptoms with the progression of labral and articular cartilage injuries ...
Grace, Trevor +5 more
core +1 more source
CartiMorph: a framework for automated knee articular cartilage morphometrics [PDF]
, 2023 We introduce CartiMorph, a framework for automated knee articular cartilage morphometrics. It takes an image as input and generates quantitative metrics for cartilage subregions, including the percentage of full-thickness cartilage loss (FCL), mean thickness, surface area, and volume.
arxiv +1 more source
Journal of Osteoporosis, 2010 Aim was to investigate fracture risk (FR) according to bone loss (BL) rate. A random sample of 1652 women aged 53.5 years was measured with dual X-ray absorptiometry in femoral neck in 1989 and 1994 and divided into tertiles of annual BL rate: high >0.84%
Joonas Sirola +8 more
doaj +1 more source