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Exosomes in cartilage microenvironment regulation and cartilage repair. [PDF]
Front Cell Dev BiolOsteoarthritis (OA) is a debilitating disease that predominantly impacts the hip, hand, and knee joints. Its pathology is defined by the progressive degradation of articular cartilage, formation of bone spurs, and synovial inflammation, resulting in pain, joint function limitations, and substantial societal and familial burdens.
Longfei H +9 more
europepmc +4 more sources
Cell therapy for cartilage repair [PDF]
Emerging Topics in Life Sciences, 2021 Regenerative medicine, using cells as therapeutic agents for the repair or regeneration of tissues and organs, offers great hope for the future of medicine. Cell therapy for treating defects in articular cartilage has been an exemplar of translating this technology to the clinic, but it is not without its challenges. These include applying regulations,
Charlotte H. Hulme +6 more
openaire +3 more sources
Journal of Cartilage & Joint Preservation, 2021 Introduction: Autologous chondrocyte implantation (ACI) has undergone several technical modifications. Objectives: To compare clinical outcomes and graft survivorship between ''first-generation'' periosteum-covered ACI (ACI-P) and ''second-generation ...
Liana Leja, MS, Tom Minas, MD, MS
doaj +1 more source
Improved diagnosis of tibiofemoral cartilage defects on MRI images using deep learning
Journal of Cartilage & Joint Preservation, 2021 Introduction: MRI is the modality of choice for cartilage imaging, however, its diagnostic performance is variable. Objectives: We aimed to evaluate whether deep learning can be utilized to accurately identify cartilage defects when applied to the ...
Gergo Merkely, M.D. +7 more
doaj +1 more source
Journal of Cartilage & Joint Preservation, 2023 Introduction: Cartilage restoration in the middle-aged population (40-60 years) is understudied. Objectives: The purpose of this study is to report the clinical outcomes and satisfaction of patients over the age of 40 years old who underwent autologous ...
Liana Leja, Tom Minas
doaj +1 more source
Patellofemoral Cartilage Repair [PDF]
Current Reviews in Musculoskeletal Medicine, 2018 This review provides an overview of well-established and newly developed cartilage repair techniques for cartilage defects in the patellofemoral joint (PFJ). An algorithm will be presented for approaching cartilage defects considering the distinct anatomy of both the patellar and trochlear articular surfaces.Recent studies on cartilage repair in the ...
Mestriner, Alexandre Barbieri +2 more
openaire +3 more sources
Materials & Design, 2022 The tissue engineering is a promising method for cartilage regeneration studies. The rough in vivo initial repair environment of articular cartilage is a challenge for the development of cartilage tissue engineering. Hereon, in this study, a silk fibroin/
Xianglong Lin +6 more
doaj +1 more source
Injectable hydrogel microspheres in cartilage repair
Biomedical Technology, 2023 The key to regenerative medicine is in situ regeneration of lesion cells, so as to achieve lesion repair and regeneration. However, the complex environment of the joint cavity where cartilage is located leads to poor efficacy of traditional therapies to ...
Feng Lin, Yihan Li, Wenguo Cui
doaj +1 more source
Bioactive Materials, 2023 Lacking self-repair abilities, injuries to articular cartilage can lead to cartilage degeneration and ultimately result in osteoarthritis. Tissue engineering based on functional bioactive scaffolds are emerging as promising approaches for articular ...
Yucong Li +15 more
doaj +1 more source
Medicina, 2023 Background and Objectives: Although the effects of cartilage repair in patients who are undergoing high tibial osteotomy (HTO) remains controversial, cartilage repair may be required for the full-thickness cartilage defect because of a concern of lower ...
Yong-Beom Park +3 more
doaj +1 more source