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Degradation and repair of articular cartilage [PDF]
Frontiers in Bioscience, 1999 Approximately 95,000 total knee replacements and 41,000 other surgical procedures to repair cartilaginous defects of the knee are performed annually in the United States (1). The response of normal articular cartilage to injury or arthritic degeneration is often a sub-optimal repair; the biochemical and mechanical properties of the new tissue differ ...
Sally R. Frenkel
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Engineering gene-activated bioprinted scaffolds for enhancing articular cartilage repair [PDF]
Materials Today BioUntreated articular cartilage injuries often result in severe chronic pain and dyskinesia. Current repair strategies have limitations in effectively promoting articular cartilage repair, underscoring the need for innovative therapeutic approaches. A gene-
Min Wang +4 more
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Articular cartilage repair and transplantation [PDF]
Arthritis & Rheumatism, 1998 Joseph A. Buckwalter, Henry J. Mankin
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Cell therapy for cartilage repair [PDF]
Emerging Topics in Life Sciences, 2021 Regenerative medicine, using cells as therapeutic agents for the repair or regeneration of tissues and organs, offers great hope for the future of medicine. Cell therapy for treating defects in articular cartilage has been an exemplar of translating this technology to the clinic, but it is not without its challenges. These include applying regulations,
Jade Perry +12 more
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Patellofemoral Cartilage Repair [PDF]
Current Reviews in Musculoskeletal Medicine, 2018 This review provides an overview of well-established and newly developed cartilage repair techniques for cartilage defects in the patellofemoral joint (PFJ). An algorithm will be presented for approaching cartilage defects considering the distinct anatomy of both the patellar and trochlear articular surfaces.Recent studies on cartilage repair in the ...
Mestriner, Alexandre Barbieri +2 more
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Medicina, 2023 Background and Objectives: Although the effects of cartilage repair in patients who are undergoing high tibial osteotomy (HTO) remains controversial, cartilage repair may be required for the full-thickness cartilage defect because of a concern of lower ...
Yong-Beom Park +3 more
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Signaling Pathways in Cartilage Repair [PDF]
International Journal of Molecular Sciences, 2014 In adult healthy cartilage, chondrocytes are in a quiescent phase characterized by a fine balance between anabolic and catabolic activities. In ageing, degenerative joint diseases and traumatic injuries of cartilage, a loss of homeostatic conditions and an up-regulation of catabolic pathways occur.
MARIANI, ERMINIA +2 more
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Challenging for cartilage repair [PDF]
BMC Sports Science, Medicine and Rehabilitation, 2009 Editorial When we look back on the past 15-year history of cartilage repair, it is clear that remarkable progress has been made in this area. There is no doubt that a lot of studies have been carried out on cartilage repair and chondrocytes since Brittebergs' report on ACI in 1994 [1].
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Effect of Transplanting Various Concentrations of a Composite of Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells and Hyaluronic Acid Hydrogel on Articular Cartilage Repair in a Rabbit Model. [PDF]
PLoS ONE, 2016 Mesenchymal stem cells (MSCs) are known to have therapeutic potential for cartilage repair. However, the optimal concentration of MSCs for cartilage repair remains unclear.
Yong-Beom Park +6 more
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Identification and clonal characterisation of a progenitor cell sub-population in normal human articular cartilage. [PDF]
PLoS ONE, 2010 BackgroundArticular cartilage displays a poor repair capacity. The aim of cell-based therapies for cartilage defects is to repair damaged joint surfaces with a functional replacement tissue.
Rebecca Williams +16 more
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