Articular chondrocytes and mesenchymal stem cells seeded on biodegradable scaffolds for the repair of cartilage in a rat osteochondral defect model [PDF]
, 2014 This work investigated the ability of co-cultures of articular chondrocytes and mesenchymal stem cells (MSCs) to repair articular cartilage in osteochondral defects.
Dahlin, Rebecca L. +6 more
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Treatment of failed articular cartilage reconstructive procedures of the knee: A systematic review [PDF]
, 2018 Background: Symptomatic articular cartilage lesions of the knee are common and are being treated surgically with increasing frequency. While many studies have reported outcomes following a variety of cartilage restoration procedures, few have ...
Lamplot, Joseph D +2 more
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Injectable hydrogel microspheres in cartilage repair
Biomedical Technology, 2023 The key to regenerative medicine is in situ regeneration of lesion cells, so as to achieve lesion repair and regeneration. However, the complex environment of the joint cavity where cartilage is located leads to poor efficacy of traditional therapies to ...
Feng Lin, Yihan Li, Wenguo Cui
doaj
Enhancing Stem Cell Therapy for Cartilage Repair in Osteoarthritis—A Hydrogel Focused Approach
Gels, 2021 Stem cells hold tremendous promise for the treatment of cartilage repair in osteoarthritis. In addition to their multipotency, stem cells possess immunomodulatory effects that can alleviate inflammation and enhance cartilage repair.
Yisi Liu +6 more
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Bone marrow cells immunomagnetically selected for CD271+ antigen promote in vitro the repair of articular cartilage defects [PDF]
, 2011 [Abstract] Objective: The purposes of this project were to quantify the cells expressing the mesenchymal stem cell (MSC) marker CD271 in synovial membranes from human osteoarthritic (OA) and healthy joints, and to determine if those CD271 cells were ...
Blanco García, Francisco J +6 more
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Materials & Design, 2022 The tissue engineering is a promising method for cartilage regeneration studies. The rough in vivo initial repair environment of articular cartilage is a challenge for the development of cartilage tissue engineering. Hereon, in this study, a silk fibroin/
Xianglong Lin +6 more
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Expression and function of cartilage-derived pluripotent cells in joint development and repair
Stem Cell Research & Therapy, 2020 Cartilage-derived pluripotent cells reside in hyaline cartilage and fibrocartilage. These cells have the potential for multidirectional differentiation; can undergo adipogenesis, osteogenesis, and chondrogenesis; and have been classified as mesenchymal ...
Zhou Jiang +3 more
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Preclinical Studies for Cartilage Repair [PDF]
CARTILAGE, 2011 Investigational devices for articular cartilage repair or replacement are considered to be significant risk devices by regulatory bodies. Therefore animal models are needed to provide proof of efficacy and safety prior to clinical testing. The financial commitment and regulatory steps needed to bring a new technology to clinical use can be major ...
Robert A. Whiteside +9 more
openaire +3 more sources
Cell-based Approaches to Joint Surface Repair : A Research Perspective [PDF]
, 2013 The authors are grateful for support to their research from Arthritis Research UK (grants 19271, 19429, 19667, 20050). None of the authors received any funding related to the writing of this manuscript, and the funding bodies did not play any role in the
A.J. Roelofs +103 more
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Advances and Prospects in Stem Cells for Cartilage Regeneration
Stem Cells International, 2017 The histological features of cartilage call attention to the fact that cartilage has a little capacity to repair itself owing to the lack of a blood supply, nerves, or lymphangion.
Mingjie Wang +16 more
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