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A review on genome editing by CRISPR-Cas9 technique for cancer treatment [PDF]

World Cancer Research Journal, 2020
In this review, we summarize CRISPR-Cas9 system-based gene modification for the therapeutic treatment of cancer. Cancer is a group of diseases involving anomalous cell growth with the potential to invade or blow out to other parts of the body, which is ...
M. Niuz Morshed Khan, K. Khaldun Islam, A. Ashraf, N. Chandra Barman   +3 more
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Gene Editing to Tackle Facioscapulohumeral Muscular Dystrophy

Frontiers in Genome Editing, 2022
Facioscapulohumeral dystrophy (FSHD) is a skeletal muscle disease caused by the aberrant expression of the DUX4 gene in the muscle tissue. To date, different therapeutic approaches have been proposed, targeting DUX4 at the DNA, RNA or protein levels. The
Virginie Mariot, Julie Dumonceaux
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Entering the post-epigenomic age: back to epigenetics [PDF]

Open Biology, 2018
It is undeniably one of the greatest findings in biology that (with some very minor exceptions) every cell in the body possesses the whole genetic information needed to generate a complete individual.
Sebastian Bultmann, Stefan H. Stricker
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Prospects for using CRISPR-Cas9 system in the treatment of human viral diseases

Acta Biomedica Scientifica, 2023
The aim. To analyze the possibility of using the genetic mechanisms of CRISPR-Cas9 technology in the prevention and treatment of certain viral diseases.Materials and methods.
A. M. Ziganshin, A. R. Mulyukov, M. A. Omarov, V. A. Mudrov, R. Sh. Khalitova   +4 more
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A genomic sequence of the type II-A clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated system in Mycoplasma salivarium strain ATCC 29803

Journal of Oral Microbiology, 2022
Introduction Clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated systems are RNA-mediated adaptive immune systems that actagainst invading genetic elements such as phages or plasmids.
Harumi Mizuki, Yu Shimoyama, Taichi Ishikawa, Minoru Sasaki   +3 more
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Tunable Transcriptional Interference at the Endogenous Alcohol Dehydrogenase Gene Locus in Drosophila melanogaster

G3: Genes, Genomes, Genetics, 2020
Neighboring sequences of a gene can influence its expression. In the phenomenon known as transcriptional interference, transcription at one region in the genome can repress transcription at a nearby region in cis. Transcriptional interference occurs at a
Victoria Jorgensen, Jingxun Chen, Helen Vander Wende, Devon E. Harris, Alicia McCarthy, Shane Breznak, Siu Wah Wong-Deyrup, Yuzhang Chen, Prashanth Rangan, Gloria Ann Brar, Eric M. Sawyer, Leon Y. Chan, Elçin Ünal   +12 more
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The Involvement of the Cas9 Gene in Virulence of Campylobacter jejuni

Frontiers in Cellular and Infection Microbiology, 2018
Campylobacter jejuni is considered as the leading cause of gastroenteritis all over the world. This bacterium has the CRISPR–cas9 system, which is used as a gene editing technique in different organisms.
Muhammad A. B. Shabbir, Yanping Tang, Zihui Xu, Mingyue Lin, Guyue Cheng, Menghong Dai, Xu Wang, Zhengli Liu, Zonghui Yuan, Zonghui Yuan, Haihong Hao, Haihong Hao   +11 more
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Optimizing CRISPR Cas9 Genome Editing System: A Review

International Journal of Endorsing Health Science Research, 2017
CRISPR Cas9 is highly advanced genome editing technology extensively used for the modifications of genetic components in various sectors of living organisms. This technology has been adapted from the prokaryotic immune system, where it plays a vital role
Meen Bahadur Budhthoki, Puja sharma, Saima Khan, Saroj Singh, Fu Chao , Li Yong   +5 more
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Evaluating the feasibility of Cas9 overexpression in 3T3-L1 cells for generation of genetic knock-out adipocyte cell lines

Adipocyte, 2021
Cell lines recapitulating physiological processes can represent alternatives to animal or human studies. The 3T3-L1 cell line is used to mimic adipocyte function and differentiation. Since transfection of 3T3-L1 cells is difficult, we used a modified 3T3-
Tomás Suchý, Isabell Kaczmarek, Tomislav Maricic, Christian Zieschang, Torsten Schöneberg, Doreen Thor, Ines Liebscher   +6 more
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Debating CRISPR/cas9 and Mitochondrial Donation: Continuity and Transition Performances at Scientific Conferences

Engaging Science, Technology, and Society, 2016
Conferences are important performative sites. Here we detail a UK science policy conference debating the novel biomedical techniques CRISPR/cas9 and mitochondrial donation.
Neil Stephens, Rebecca Dimond
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