Casein Kinase 2 Signaling in White Matter Stroke [PDF]
Frontiers in Molecular Biosciences, 2022 The growth of the aging population, together with improved stroke care, has resulted in an increase in stroke survivors and a rise in recurrent events.
Hung Nguyen, Wenbin Zhu, Selva Baltan
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ROCK2-Specific Inhibitor KD025 Suppresses Adipocyte Differentiation by Inhibiting Casein Kinase 2 [PDF]
Molecules, 2021 KD025, a ROCK2 isoform-specific inhibitor, has an anti-adipogenic activity which is not mediated by ROCK2 inhibition. To identify the target, we searched binding targets of KD025 by using the KINOMEscanTM screening platform, and we identified casein ...
Nhu Nguyen Quynh Tran, Kwang-Hoon Chun
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Inhibition of casein kinase 2 induces cell death in tyrosine kinase inhibitor resistant chronic myelogenous leukemia cells. [PDF]
PLoS ONE, 2023 Chronic myelogenous leukemia (CML) is a myeloproliferative disease characterized by the BCR-ABL oncogene. Despite the high performance of treatment with tyrosine kinase inhibitors (TKI), about 30% of patients develop resistance to the therapy. To improve
Ondřej Mitrovský +8 more
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Identification of casein kinase 1, casein kinase 2, and cAMP-dependent protein kinase-like activities in Trypanosoma evansi [PDF]
Memorias do Instituto Oswaldo Cruz, 2004 Trypanosoma evansi contains protein kinases capable of phosphorylating endogenous substrates with apparent molecular masses in the range between 20 and 205 kDa.
José Manuel Galán-Caridad +4 more
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Casein Kinase 2 dependent phosphorylation of eIF4B regulates BACE1 expression in Alzheimer’s disease [PDF]
Cell Death and Disease, 2021 Alzheimer’s disease (AD) is the most common age-related neurodegenerative disorder. Increased Aβ production plays a fundamental role in the pathogenesis of the disease and BACE1, the protease that triggers the amyloidogenic processing of APP, is a key ...
Barbara Bettegazzi +13 more
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The catalytic subunit of Plasmodium falciparum casein kinase 2 is essential for gametocytogenesis [PDF]
Communications Biology, 2021 Hitz et al. describe the role of the protein kinase PfCK2α in the development of the human malaria parasite Plasmodium falciparum. Using mutant parasites, they show that PfCK2α is not only essential for asexual but also sexual development of P ...
Eva Hitz +8 more
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Casein kinase 2 attenuates brain injury induced by intracerebral hemorrhage via regulation of NR2B phosphorylation [PDF]
Frontiers in Cellular Neuroscience, 2022 ObjectiveIntracerebral hemorrhage (ICH) is a common cerebrovascular disease with high incidence, disability, and mortality. Casein kinase 2 (CK2) is a serine/threonine kinase with hundreds of identified substrates and plays an important role in many ...
Zhimin Sun +11 more
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Phosphorylation of hepatic insulin receptor by casein kinase 2 [PDF]
FEBS Letters, 1988 Casein kinase 2 was able to phosphorylate the β‐subunit of hepatic insulin receptor in the presence of either ATP or GTP. Phosphorylation by casein kinase 2 was observed even in the absence of insulin, was inhibited by low heparin concentrations, and led to the incorporation of phosphate on serine and threonine residues. Casein kinase 2 phosphorylation
Emilio Itarte
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Casein kinase 2 inhibition sensitizes medulloblastoma to temozolomide. [PDF]
Oncogene, 2019 Medulloblastoma (MB) is the most common malignant pediatric brain tumor. Since surviving patients experience severe neurocognitive disabilities, better and more effective treatments are needed to enhance their quality of life. Casein kinase 2 (CK2) is known to regulate cell growth and survival in multiple cancers; however, the role of CK2 in MB is ...
Nitta RT +9 more
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Crystal structure of Arabidopsis thaliana casein kinase 2 α1. [PDF]
Acta Crystallogr F Struct Biol Commun, 2020 Casein kinase 2 (CK2) is a ubiquitous pleiotropic enzyme that is highly conserved across eukaryotic kingdoms. CK2 is singular amongst kinases as it is highly rigid and constitutively active. Arabidopsis thaliana is widely used as a model system in molecular plant research; the biological functions of A. thaliana CK2 are well studied in vivo and many of
Demulder M, De Veylder L, Loris R.
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