Results 11 to 20 of about 43,522 (228)

Optimal interleukin-7 receptor-mediated signaling, cell cycle progression and viability of T-cell acute lymphoblastic leukemia cells rely on casein kinase 2 activity

Haematologica, 2016
Interleukin-7 and interleukin-7 receptor are essential for normal T-cell development and homeostasis, whereas excessive interleukin-7/interleukin-7 receptor-mediated signaling promotes leukemogenesis. The protein kinase, casein kinase 2, is overexpressed
Alice Melão, Maureen Spit, Bruno A. Cardoso, João T. Barata   +3 more
doaj   +3 more sources

Prothymosin α is phosphorylated by casein kinase‐2 [PDF]

FEBS Letters, 1992
Prothymosin α (ProTα) is a 12.5 kDa acidic polypeptide that is considered to have a nuclear function related to cell proliferation. Inspection of its amino acid sequence revealed the presence of sequences that may serve as targets for phosphorylation by casein kinase‐2 (CK‐2). ProTα isolated from calf thymocytes was phosphorylated in vitro by CK‐2. The
Barcia, Miguel G., Castro, José M., Jullien, Cristina D., González, Carlos G., Freire, Manuel   +4 more
openaire   +3 more sources

Casein Kinase 2—A Kinase that Inhibits Brown Fat Formation [PDF]

Cell Metabolism, 2015
In adipose tissue, there is a delicate balance between storing and expending energy. In this issue, Shinoda et al. (2015) use phosphoproteomics to identify casein kinase 2 (CK2) as a suppressor of brown adipocyte formation, providing insights into how adipose tissue regulates its composition of white versus brown adipocytes.
Enerbäck, Sven, Enerbäck, Sven,
openaire   +3 more sources

The phosphorylation of nucleoplasmin by casein kinase‐2 is resistant to heparin inhibition [PDF]

FEBS Letters, 1987
Highly purified preparations of casein kinase‐2 from the nuclei of Xenopus laevis oocytes and from calf thymus can phosphorylate in vitro purified nucleoplasmin from X. laevis oocytes and eggs. The phosphorylation of nucleoplasmin by both kinase preparations is quite insensitive to heparin in contrast with casein phosphorylation which is completely ...
Taylor, Aída, Allende, Catherine C., Weinmann, Roberto, Allende, Jorge E.   +3 more
openaire   +4 more sources

Prion protein inhibits fast axonal transport through a mechanism involving casein kinase 2. [PDF]

PLoS ONE, 2017
Prion diseases include a number of progressive neuropathies involving conformational changes in cellular prion protein (PrPc) that may be fatal sporadic, familial or infectious.
Emiliano Zamponi, Fiamma Buratti, Gabriel Cataldi, Hector Hugo Caicedo, Yuyu Song, Lisa M Jungbauer, Mary J LaDu, Mariano Bisbal, Alfredo Lorenzo, Jiyan Ma, Pablo R Helguera, Gerardo A Morfini, Scott T Brady, Gustavo F Pigino   +13 more
doaj   +3 more sources

Modulation of transcriptional mineralocorticoid receptor activity by casein kinase 2 [PDF]

Scientific Reports, 2017
AbstractThe pathogenesis of cardiovascular diseases is a multifunctional process in which the mineralocorticoid receptor (MR), a ligand-dependent transcription factor, is involved as proven by numerous clinical studies. The development of pathophysiological MR actions depends on the existence of additional factors e.g.
Ruhs, Stefanie, Strätz, Nicole, Quarch, Katja, Masch, Antonia, Schutkowski, Mike, Gekle, Michael, Grossmann, Claudia   +6 more
openaire   +3 more sources

Activated CaMKII Couples GluN2B and Casein Kinase 2 to Control Synaptic NMDA Receptors [PDF]

Cell Reports, 2013
Synaptic activity triggers a profound reorganization of the molecular composition of excitatory synapses. For example, NMDA receptors are removed from synapses in an activity- and calcium-dependent manner, via casein kinase 2 (CK2) phosphorylation of the
Antonio Sanz-Clemente, John A. Gray, Kyle A. Ogilvie, Roger A. Nicoll, Katherine W. Roche   +4 more
doaj   +2 more sources

The consensus sequences for cdc2 kinase and for casein kinase‐2 are mutually incompatible A study with peptides derived from the β‐subunit of casein kinase‐2 [PDF]

FEBS Letters, 1992
Two series of synthetic peptides that reproduce the amino‐ and carboxyl‐terminal segments of the β‐subunit of casein kinase‐2, including the sites phosphorylated by CK2 and cdc2 kinase, respectively, have been used as model substrates for these enzymes.
MARIN, ORIANO, MEGGIO, FLAVIO, Draetta G, PINNA, LORENZO   +3 more
openaire   +4 more sources

Casein kinase 2 complex: a central regulator of multiple pathobiological signaling pathways in Cryptococcus neoformans [PDF]

mBio
The casein kinase 2 (CK2) complex has garnered extensive attention over the past decades as a potential therapeutic target for diverse human diseases, including cancer, diabetes, and obesity, due to its pivotal roles in eukaryotic growth, differentiation,
Yeseul Choi, Seong-Ryong Yu, Yujin Lee, Ann-Yae Na, Sangkyu Lee, Joseph Heitman, Ran Seo, Han-Seung Lee, Jong-Seung Lee, Yong-Sun Bahn   +9 more
doaj   +2 more sources

Modeling protein-protein interactions in axon initial segment to understand their potential impact on action potential initiation

Neural Regeneration Research, 2021
The axon initial segment (AIS) region is crucial for action potential initiation due to the presence of high-density AIS protein voltage-gated sodium channels (Nav).
Piyush Bhardwaj, Don Kulasiri, Sandhya Samarasinghe   +2 more
doaj   +1 more source