Results 71 to 80 of about 34,988 (231)

Casein Kinase 2 Mediates Degradation of Transcription Factor Pcf1 during Appressorium Formation in the Rice Blast Fungus

Journal of Fungi, 2022
The appressorium is a specialized structure that is differentiated from Magnaporthe oryzae spores that can infect host cells. In the process of cellular transformation from spore to appressorium, the contents inside the spores are transferred into ...
Pengyun Huang, Yan Li, Jing Wang, Qing Wang, Zhicheng Huang, Xiaohong Liu, Fucheng Lin, Jianping Lu   +7 more
doaj   +1 more source

Small‐Molecule Kinase Inhibitors Modulating Circadian Rhythms

Medicinal Research Reviews, EarlyView.
ABSTRACT The circadian clock mechanism generates 24‐h rhythms crucial for regulating various physiological processes, and its dysregulation has been implicated in numerous diseases. In cells, the circadian clock operates through a transcriptional‐translational feedback loop, where phosphorylation plays a pivotal role in maintaining accurate circadian ...
Irene Castellino, Manuela Bartolini, Rudolf Andrys, Kamil Musilek   +3 more
wiley   +1 more source

Expression und Lokalisation der Casein Kinase I-epsilon (CKI-epsilon) in Organen der Maus sowie Nachweis von Expressionsveränderungen der Casein Kinase I-epsilon in Tumoren

, 2010
Casein Kinase I-epsilon (CKI-epsilon) spielt eine Rolle in vielen zellulären Prozessen, wie Zellwachstum und -differenzierung, Apoptose und Vesikeltransport.
Utz, Anja Christina
core   +1 more source

Structural Insights Into the Function of Leishmania major Adenylosuccinate Lyase

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT One of several intriguing aspects of kinetoplastid biochemistry is the complete dependence on host purines and purine recycling due to the lack of a de novo purine biosynthesis pathway. Adenylosuccinate lyase (ASL, EC 4.3.2.2) is a key enzyme in the purine synthesis pathway responsible for the conversion of adenylosuccinate into adenosine ...
Ivan R. e Silva, Monique Mantovani, Maria E. S. D. Lino, Aline O. Albuquerque, João H. M. da Silva, Ronaldo A. P. Nagem, Adriana L. Rojas, Geraldo R. Sartori, Eduardo Horjales, David Campbell, Otavio H. Thiemann   +10 more
wiley   +1 more source

Phosphorylation by Casein Kinase I Promotes the Turnover of the Mdm2 Oncoprotein via the SCFβ-TRCP Ubiquitin Ligase

, 2010
SummaryMdm2 is the major negative regulator of the p53 pathway. Here, we report that Mdm2 is rapidly degraded after DNA damage and that phosphorylation of Mdm2 by casein kinase I (CKI) at multiple sites triggers its interaction with, and subsequent ...
Stommel, Jayne M., Inuzuka, Hiroyuki, Zhai, Bo, Alan Tseng, Caroline Mock, Xiao, Zhi-Xiong Jim, Ang, Xiaolu L., Harper, J. Wade, Shaik, Shavali, Haoqiang Yin, Wan, Lixin, Hiroyuki Inuzuka, Shavali Shaik, Galit Lahav, Asara, John, Lixin Wan, Gao, Daming, Gygi, Steven, Zhi-Xiong Jim Xiao, Tseng, Alan, Daming Gao, Xiaolu L. Ang, Qing Zhang, Kaelin, William G., Mock, Caroline, Lahav, Galit, Wei, Wenyi, J. Wade Harper, Jayne M. Stommel, William G. Kaelin, John Asara, Bo Zhai, Wenyi Wei, Zhang, Qing, Yin, Haoqiang, Steven Gygi   +35 more
core   +1 more source

Casein Kinase I Regulates Membrane Binding by ARF GAP1 [PDF]

Molecular Biology of the Cell, 2002
ARF GAP1, a 415-amino acid GTPase activating protein (GAP) for ADP-ribosylation factor (ARF) contains an amino-terminal 115-amino acid catalytic domain and no other recognizable features. Amino acids 203–334 of ARF GAP1 were sufficient to target a GFP-fusion protein to Golgi membranes in vivo.
Sidney, Yu, Michael G, Roth
openaire   +2 more sources

Responsive nitric oxide‐releasing antibacterial materials for biofilm‐associated infections: Mechanisms, design strategies, and applications

Responsive Materials, EarlyView.
This review summarizes the recent progress in responsive NO‐releasing materials and their applications in biofilm‐associated infectious diseases. The design principles and response mechanisms are given to provide inspiration toward the future development of multi‐responsive NO‐releasing materials.
Wenyue Sun, Meiqi Li, Di Nan, Jiaqi Zhao, Yu Chen, Yao Gao, Shichen Zhang, Kirsten L. Van Landuyt, Manlin Qi   +8 more
wiley   +1 more source

LDHU3_04.1500

, 2021
casein kinase I Leishmania donovani (HU3 ...
Requena, J (via Mendeley Data)
core   +1 more source

DNA‐Enzyme Hybrid Nanostructures: Functional Materials to Modulate Enzymatic Activity

Small, EarlyView.
DNA–enzyme hybrid nanostructures enable precise spatial and stoichiometric control over enzyme organization, offering a powerful platform to modulate catalytic activity. This review critically evaluates key mechanistic hypotheses, including proximity effects, microenvironment changes, confinement, and stabilization, as well as highlighting ...
Manar Elnaggar, Amelie Heuer‐Jungemann
wiley   +1 more source

Interactions between Casein kinase Iepsilon (CKIepsilon) and two substrates from disparate signaling pathways reveal mechanisms for substrate-kinase specificity. [PDF]

PLoS ONE, 2009
Members of the Casein Kinase I (CKI) family of serine/threonine kinases regulate diverse biological pathways. The seven mammalian CKI isoforms contain a highly conserved kinase domain and divergent amino- and carboxy-termini.
Caroline Lund Dahlberg, Elizabeth Z Nguyen, David Goodlett, David Kimelman   +3 more
doaj   +1 more source