Results 81 to 90 of about 34,988 (231)
Journal of Animal Ecology, EarlyView.Replicated mainland–islet populations of the Skyros wall lizard reveal consistent divergence in digestive physiology, including gut morphology, passage time, digestive efficiency and enzyme activity. These results show how ecological variation in resource availability can shape digestive performance across populations in insular environments.
Aikaterini Reppa +8 more
wiley +1 more source
Casein kinase I delta controls centrosome positioning during T cell activation
, 2011 Although termed central body, the centrosome is located off-center in many polarized cells. T cell receptor (TCR) engagement by antigens induces a polarity switch in T cells.
Fanni Gergely +2 more
core +1 more source
The DUF1669 domain of FAM83H is required for its localization to nuclear speckles
Scientific ReportsAutosomal-dominant hypocalcified amelogenesis imperfecta (ADHCAI) is caused by mutations in the FAM83H gene. Mutated FAM83H genes encode truncated FAM83H proteins with amino acid lengths between amino acids 1–286 and 1–693, in contrast to wild-type ...
Takahisa Kuga +9 more
doaj +1 more source
DBT affects sleep in both circadian and non-circadian neurons
PLoS Genetics, 2022 Sleep is a very important behavior observed in almost all animals. Importantly, sleep is subject to both circadian and homeostatic regulation. The circadian rhythm determines the daily alternation of the sleep-wake cycle, while homeostasis mediates the ...
Jialin Wang +4 more
doaj
Lewy bodies are surrounded by granulovacuolar degeneration bodies in dementia with Lewy bodies
Brain Pathology, EarlyView.Here, we report Lewy bodies (LBs) to be enriched for tau‐laden granulovacuolar degeneration bodies (GVBs), suggesting a potential mechanistic interface between α‐synuclein and tau pathology in dementia with Lewy bodies (DLB). Abstract Lewy bodies (LBs), composed primarily of aggregated α‐synuclein (α‐syn), are the pathological hallmark of Lewy body ...
Searlait Thom +7 more
wiley +1 more source
Budding and Fission Yeast Casein Kinase-I Isoforms Have Dual-Specificity Protein-Kinase Activity
, 1994 We have examined the activity and substrate specificity of the Saccharomyces cerevisiae Hrr25p and the Schizosaccharomyces pombe Hhp1, Hhp2, and Cki1 protein kinase isoforms.
Dhillon, N. +6 more
core +1 more source
The FEBS Journal, EarlyView.Okur‐Chung neurodevelopmental syndrome (OCNDS) is a neurodevelopmental disorder associated with mutations in the gene coding for Protein kinase CK2α. In this work, 42 variants of CK2α associated with OCNDS were characterized in vitro. This included determination of catalytic activity and CK2α/CK2β‐interaction as well as an assessment of evolutionary ...
Alexander Gast +3 more
wiley +1 more source
Stimulation of Suicidal Erythrocyte Death by Ceritinib-Treatment of Human Erythrocytes
Cellular Physiology and Biochemistry, 2016 Background/Aims: The anaplastic lymphoma kinase (ALK) inhibitor ceritinib is utilized for the treatment of ALK positive non-small cell lung carcinoma. Side effects of the drug include decrease of blood hemoglobin concentration.
Abdulla Al Mamun Bhuyan +3 more
doaj +1 more source
Phosphorylation of synaptotagmin I by casein kinase II.
Journal of Biological Chemistry, 1993 Synaptotagmin I is an abundant synaptic vesicle protein that binds Ca2+ in a phospholipid-dependent manner and is thought to function in synaptic vesicle exocytosis. We have now studied the phosphorylation of synaptotagmin I. Synaptotagmin I is one of the major substrates in brain for casein kinase II, which phosphorylates synaptotagmin at a single ...
B, Davletov +6 more
openaire +2 more sources
Molecular Microbiology, EarlyView.LexR1 is a LuxR‐type regulator that links nutrient sensing to effector gene expression in Legionella. Activated by a casamino acid‐derived ligand, LexR1 directly controls multiple effector genes using a conserved regulatory element present in numerous putative effectors across different Legionella species.
Chen Adler, Gil Segal
wiley +1 more source