Results 61 to 70 of about 24,797 (285)

Rewiring nutrition: Chemical insights into the physiological and microbiological roles of food's microconstituents

Food Biomacromolecules, EarlyView.
Bidirectional interactions between food‐derived sensory compounds, gut sensing and microbiota, host physiological feedback, and metabolite production within the food matrix collectively shape sensory perception, microbial dynamics, and metabolic health.
Mohammad Nazrul Islam Bhuiyan
wiley   +1 more source

Harnessing microbial metabolism and nutrition to target the gut–mammary axis for better livestock production and health

iMetaOmics, EarlyView.
The gut–mammary axis integrates intestinal health with mammary function through neural, endocrine, and immune pathways. Nutritional interventions (probiotics, prebiotics, metabolites) improve gut microecology, generating microbial signals that travel via the axis to the mammary gland. There, they relieve inflammation, enhance milk quality and lactation,
Aolong Zhou, Cheng Guo, Mahmoud M. Abdelsattar, Ahmad R. Musa, Mequanint Biks, Abdullahi A. Musa, Shahnaz Rahman, Abera Teshome Aleli, Pei Zhong, Jiawei Zhang, Junwei Cui, Xiyan Kou, Qingyuan Yu, Caijuan Yue, Qin Li, Dan Zhang, Zixuan Peng, Ao Ren, Ziqi Tian, Ziqi Liu, Yaona Zhang, Lili Zhang, Dina Karmallah, Naifeng Zhang, Tao Ma, Yan Tu, Qiyu Diao, Guijie Zhang, Xiaofeng Xu, Yanliang Bi   +29 more
wiley   +1 more source

Targeting Casein Kinases in the Fungal Pathogen Candida albicans

, 2020
Fungal pathogens are a major public health burden. We previously screened a library of over 700 protein kinase inhibitors and identified compounds with potent antifungal activity in combination with the echinocandin antifungal drug caspofungin, against ...
Hyde, Sabrina Claudia
core   +1 more source

Identifying human kinase-specific protein phosphorylation sites by integrating heterogeneous information from various sources. [PDF]

PLoS ONE, 2010
Phosphorylation is an important type of protein post-translational modification. Identification of possible phosphorylation sites of a protein is important for understanding its functions.
Tingting Li, Pufeng Du, Nanfang Xu
doaj   +1 more source

Targeting casein kinase 1 for cancer therapy: current strategies and future perspectives

Frontiers in Oncology, 2023
Casein Kinase 1 (CK1) is a family of serine/threonine protein kinases that play a crucial role in various cellular processes, including cell proliferation, survival, and metabolism.
Ngo Hoang Long, Sook-Jeong Lee
doaj   +1 more source

Mixed lineage kinase 3 mediates SARS‐CoV‐2‐induced kidney injury via the Hsp70‐IL‐17A axis

Interdisciplinary Medicine, EarlyView.
Kidney samples from patients infected with severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) showed upregulated expression and activity of Mixed Lineage Kinase (MLK3). Based on the mechanistic studies, we identified MLK3 as a critical player in promoting SARS‐CoV‐2‐induced kidney injury.
Sandeep Kumar, Sunil Kumar Singh, Piush Srivastava, Sowdhamini Mahendiran, Rakesh Sathish Nair, Harsh Vyas, Saket Jha, Niraj Nag, Navin Viswakarma, Hitesh Kapoor, Swathi Suresh, Periannan Sethupathi, Sang‐Ging Ong, Jerrold S. Levine, Suman Setty, Mathayan Manikannan, Bellur S. Prabhakar, Basabi Rana, Ajay Rana   +18 more
wiley   +1 more source

Casein Kinase 1 Family Member CK1δ/Hrr25 Is Required for Autophagosome Completion

Frontiers in Cell and Developmental Biology, 2020
Autophagy starts with the initiation and nucleation of isolation membranes, which further expand and seal to form autophagosomes. The regulation of isolation membrane closure remains poorly understood.
Yuting Li, Xuechai Chen, Qianqian Xiong, Yong Chen, Hongyu Zhao, Muhammad Tahir, Jingdong Song, Bing Zhou, Juan Wang   +8 more
doaj   +1 more source

The transcription factor YY1 is a novel substrate for Aurora B kinase at G2/M transition of the cell cycle. [PDF]

PLoS ONE, 2012
Yin Yang 1 (YY1) is a ubiquitously expressed and highly conserved multifunctional transcription factor that is involved in a variety of cellular processes. Many YY1-regulated genes have crucial roles in cell proliferation, differentiation, apoptosis, and
Ari Kassardjian, Raed Rizkallah, Sarah Riman, Samuel H Renfro, Karen E Alexander, Myra M Hurt   +5 more
doaj   +1 more source

Isolation and characterization of a Type II casein kinase (‘casein kinase‐TS’) from Saccharomyces cerevisiae [PDF]

FEBS Letters, 1982
Among the several classes of protein kinases described up to now the so called ‘casein kinases’ are characterized by their insensitivity to any of the known effecters of other protein kinases, like cyclic nucleotides, Ca* + , calmodulin and phospholipids and by their remarkable activity in vitro toward casein and phosvitin but not toward histones and ...
RIGOBELLO, MARIA PIA, JORI E., CARIGNANI, GIOVANNA, PINNA, LORENZO   +3 more
openaire   +2 more sources

Small‐Molecule Kinase Inhibitors Modulating Circadian Rhythms

Medicinal Research Reviews, EarlyView.
ABSTRACT The circadian clock mechanism generates 24‐h rhythms crucial for regulating various physiological processes, and its dysregulation has been implicated in numerous diseases. In cells, the circadian clock operates through a transcriptional‐translational feedback loop, where phosphorylation plays a pivotal role in maintaining accurate circadian ...
Irene Castellino, Manuela Bartolini, Rudolf Andrys, Kamil Musilek   +3 more
wiley   +1 more source