Results 41 to 50 of about 24,797 (285)

Further purification and characterization of casein kinases from human erythrocyte hemolysate. Effect of Triton X-100.

, 1981
Two cyclic AMP-independent casein kinases can be isolated from human erythrocyte hemolysate, one of which (referred to as 'casein kinase S') phosphorylates only serine residues of whole commercial casein, while the other (referred to as 'casein kinase TS'
CLARI, GIULIO, V. Moret
core   +1 more source

Molecular dissection of Chagas induced cardiomyopathy reveals central disease associated and druggable signaling pathways.

PLoS Neglected Tropical Diseases, 2020
Chagas disease, the clinical presentation of T. cruzi infection, is a major human health concern. While the acute phase of Chagas disease is typically asymptomatic and self-resolving, chronically infected individuals suffer numerous sequelae later in ...
Jacob M Wozniak, Tatiana Araújo Silva, Diane Thomas, Jair L Siqueira-Neto, James H McKerrow, David J Gonzalez, Claudia M Calvet   +6 more
doaj   +1 more source

Inhibition of casein kinase 1 δ/ε improves cognitive performance in adult C57BL/6J mice

Scientific Reports, 2021
Time-of-day effects have been noted in a wide variety of cognitive behavioral tests, and perturbation of the circadian system, either at the level of the master clock in the SCN or downstream, impairs hippocampus-dependent learning and memory.
Heather Mahoney, Emily Peterson, Hannah Justin, David Gonzalez, Christopher Cardona, Korey Stevanovic, John Faulkner, Amara Yunus, Alexandra Portugues, Amy Henriksen, Camden Burns, Cameron McNeill, Joshua Gamsby, Danielle Gulick   +13 more
doaj   +1 more source

Sequential activation and inactivation of Dishevelled in the Wnt/beta-catenin pathway by casein kinases. [PDF]

J Biol Chem, 2011
Bernatik O, Ganji RS, Dijksterhuis JP, Konik P, Cervenka I, Polonio T, Krejci P, Schulte G, Bryja V.   +8 more
europepmc   +2 more sources

Bifidobacterium Pseudolongum‐Derived Inosine Mitigates Polystyrene Nanoplastics‐Induced Hepatic Injury by Inhibiting the Polarization of M1 Macrophages

Advanced Science, EarlyView.
Probiotic B.p colonization elevated gut‐derived inosine level in the liver, while elevated inosine activated A2AR and subsequently blocked NPs‐induced polarization of M1 macrophages by repressing the miR155/SOCS1/NF‐κB pathway. This reduced the release of inflammatory cytokines and thereby, mitigated NPs‐induced hepatic injury.
Kaikai Zhang, Yuchuan Chen, Jiayuan Wan, Jianzheng Yang, Lijian Chen, Qingyuan Li, Anding Zhou, Nian Zhou, Jiuyang Ding, Qi Wang, Jian Sun   +10 more
wiley   +1 more source

Betulin, a Newly Characterized Compound in Acacia auriculiformis Bark, Is a Multi-Target Protein Kinase Inhibitor

Molecules, 2021
The purpose of this work is to investigate the protein kinase inhibitory activity of constituents from Acacia auriculiformis stem bark. Column chromatography and NMR spectroscopy were used to purify and characterize betulin from an ethyl acetate soluble ...
Augustine A. Ahmadu, Claire Delehouzé, Anas Haruna, Lukman Mustapha, Bilqis A. Lawal, Aniefiok Udobre, Blandine Baratte, Camilla Triscornia, Axelle Autret, Thomas Robert, Jeannette Chloë Bulinski, Morgane Rousselot, Mélanie Simoes Eugénio, Marie-Thérèse Dimanche-Boitrel, Jacobus P. Petzer, Lesetja J. Legoabe, Stéphane Bach   +16 more
doaj   +1 more source

CK2α Deficiency Drives Myocardial Fibrosis via Desmin‐Induced Mitochondrial Dysfunction

Advanced Science, EarlyView.
CK2α preserves mitochondrial homeostasis by phosphorylating Desmin to recruit Cryab, ensuring proper filament assembly. CK2α deficiency disrupts this interaction, causing mitochondrial dysfunction, metabolic shifts, bioenergetic failure, and oxidative stress—ultimately establishing a pro‐fibrotic environment that drives cardiac fibrosis.
Canjie Ma, Jiali Jia, Juncong Lan, Jing Wang, Dan Rao, Lanlan Rao, Weibin Zhang, Dongpeng Wu, Jie Zhang, Gang Wang, Baohua Liu, Ying Ao, Zimei Wang   +12 more
wiley   +1 more source

Gli Phosphorylation Code in Hedgehog Signal Transduction

Frontiers in Cell and Developmental Biology, 2022
Hedgehog (Hh) family of secreted proteins governs many key processes in embryonic development and adult tissue homeostasis in species ranging from insects to human.
Mengmeng Zhou, Jin Jiang, Jin Jiang
doaj   +1 more source

Dynamic Single‐Binding Event Profiling With on‐Chip Microlenses for Wash‐Free Digital Biosensing

Advanced Science, EarlyView.
A microlens‐enhanced platform enables real‐time tracking and digital counting of single‐binding events using conventional bright‐field microscopy. Amplified scattering signals from gold nanoparticle labels and kinetic signature analysis allow wash‐free discrimination between specific and nonspecific interactions, while providing kinetic and mechanistic
Tingting Zhan, Lianyu Lu, Guoqiang Gu, Pengcheng Zhang, Jienan Shen, Xiaotian Tan, Wei Ye, Shi Hu, Yi Zhang, Hao Yu, Shaoqin Liu, Hairong Zheng, Hui Yang   +12 more
wiley   +1 more source

Time-dependent antagonist-agonist switching in receptor tyrosine kinase-mediated signaling

BMC Bioinformatics, 2019
Background ErbB4/HER4 is a unique member of the ErbB family of receptor tyrosine kinases concerning its activation of anti-proliferative JAK2-STAT5 pathway when stimulated by ligand Neuregulin (NRG).
Alokendra Ghosh, Ravi Radhakrishnan
doaj   +1 more source