Results 31 to 40 of about 24,797 (285)

Phosphorylation of varicella-zoster virus IE63 protein by casein kinases influences its cellular localization and gene regulation activity. [PDF]

, 2002
peer reviewedDuring the early phase of varicella-zoster virus (VZV) infection, Immediate Early protein 63 (IE63) is expressed rapidly and abundantly in the nucleus, while during latency, this protein is confined mostly to the cytoplasm.
Bontems, Sébastien, Sadzot-Delvaux, Catherine, Piette, Jacques, Baudoux, Laurence, Rentier, Bernard, Di Valentin, Emmanuel   +5 more
core   +1 more source

The Haemonchus contortus kinome - a resource for fundamental molecular investigations and drug discovery

Parasites & Vectors, 2015
Background Protein kinases regulate a plethora of essential signalling and other biological pathways in all eukaryotic organisms, but very little is known about them in most parasitic nematodes.
Andreas J. Stroehlein, Neil D. Young, Pasi K. Korhonen, Abdul Jabbar, Andreas Hofmann, Paul W. Sternberg, Robin B. Gasser   +6 more
doaj   +1 more source

Computer-Aided Drug Design Applied to Marine Drug Discovery: Meridianins as Alzheimer’s Disease Therapeutic Agents

Marine Drugs, 2017
Computer-aided drug discovery/design (CADD) techniques allow the identification of natural products that are capable of modulating protein functions in pathogenesis-related pathways, constituting one of the most promising lines followed in drug discovery.
Laura Llorach-Pares, Alfons Nonell-Canals, Melchor Sanchez-Martinez, Conxita Avila   +3 more
doaj   +1 more source

Phosphorylation of fibrinogen by casein kinase 2 [PDF]

Biochemical Journal, 1986
Casein kinase 2 from rat liver cytosol phosphorylated human fibrinogen in a reaction that was not stimulated by Ca2+ or cyclic AMP, but was markedly inhibited by heparin, and proceeded at a similar rate when either ATP or GTP was used as phosphate donor.
M D, Guasch, M, Plana, J M, Pena, E, Itarte   +3 more
openaire   +2 more sources

Characterization of three casein kinases type I from Dictyostelium discoideum

, 2013
Three different casein kinases type I have been characterized and partially purified from vegetative cells of Dictyostelium discoideum. The enzymes have been classified as type I because they are excluded from DEAE cellulose columns and do not utilize ...
Ospina, Blanca, Fernández-Renart, Margarita   +1 more
core   +1 more source

Casein Kinase II in Theileriosis

Science, 1995
East Coast fever is an acute, leukemia-like disease of cattle and Cape buffalo that is endemic in eastern, central, and southern Africa, where the disease causes high mortality and losses in livestock production. It is caused by the parasite Theileria parva, which infects bovine lymphocytolysis.
openaire   +3 more sources

Kinome profiling of myxoid liposarcoma reveals NF-kappaB-pathway kinase activity and Casein Kinase II inhibition as a potential treatment option

Molecular Cancer, 2010
Background Myxoid liposarcoma is a relatively common malignant soft tissue tumor, characterized by a (12;16) translocation resulting in a FUS-DDIT3 fusion gene playing a pivotal role in its tumorigenesis.
Szuhai Karoly, Bruijn Inge, Schrage Yvonne M, Willems Stefan M, Hogendoorn Pancras CW, Bovée Judith VMG   +5 more
doaj   +1 more source

Trisubstituted pyrazolopyrimidines as novel angiogenesis inhibitors. [PDF]

, 2013
Current inhibitors of angiogenesis comprise either therapeutic antibodies (e.g. bevacicumab binding to VEGF-A) or small molecular inhibitors of receptor tyrosin kinases like e.g. sunitinib, which inhibits PDGFR and VEGFR.
Gucký, Tomáš, Stefan Zahler, Krystof, Vladimir, Strnad, Miroslav, Liebl, Johanna, Vollmar, Angelika M., Fürst, Robert, Vladimir Krystof, Robert Fürst, Sabine B Weitensteiner, Miroslav Strnad, Johanna Liebl, Havlíček, Libor, Tomáš Gucký, Weitensteiner, Sabine B., Zahler, Stefan, Libor Havlíček, Angelika M Vollmar   +17 more
core   +1 more source

The Drosophila splicing factor PSI is phosphorylated by casein kinase II and tousled-like kinase. [PDF]

PLoS ONE, 2013
Alternative splicing of pre-mRNA is a highly regulated process that allows cells to change their genetic informational output. These changes are mediated by protein factors that directly bind specific pre-mRNA sequences.
J Matthew Taliaferro, Dhruv Marwha, Julie L Aspden, Daniela Mavrici, Nathalie E Cheng, Lori A Kohlstaedt, Donald C Rio   +6 more
doaj   +1 more source

Regulation of Pkc1 Hyper-Phosphorylation by Genotoxic Stress

Journal of Fungi, 2021
The cell wall integrity (CWI) signaling pathway is best known for its roles in cell wall biogenesis. However, it is also thought to participate in the response to genotoxic stress.
Li Liu, Jiri Veis, Wolfgang Reiter, Edwin Motari, Catherine E. Costello, John C. Samuelson, Gustav Ammerer, David E. Levin   +7 more
doaj   +1 more source