The casein kinase MoYck1 regulates development, autophagy, and virulence in the rice blast fungus
Virulence, 2019 Casein kinases are serine/threonine protein kinases that are evolutionarily conserved in yeast and humans and are involved in a range of important cellular processes.
Huan-Bin Shi +7 more
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Casein kinases as potential therapeutic targets
Expert Opinion on Therapeutic Targets, 2015 Introduction: The conventional term ‘casein kinase’ (CK) denotes three classes of kinases – CK1, CK2 and Golgi-CK (G-CK)/Fam20C (family with sequence similarity 20, member C) – sharing the ability to phoshorylate casein in vitro, but otherwise unrelated to each other.
COZZA, GIORGIO, Pinna, Lorenzo A.
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The casein kinases Yck1p and Yck2p act in the secretory pathway, in part, by regulating the Rab exchange factor Sec2p. [PDF]
Mol Biol Cell, 2016 Sec2p is a guanine nucleotide exchange factor that activates Sec4p, the final Rab GTPase of the yeast secretory pathway. Sec2p is recruited to secretory vesicles by the upstream Rab Ypt32p acting in concert with phosphatidylinositol-4-phosphate (PI(4)P).
Stalder D, Novick PJ.
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Casein kinases I and 2α phosphorylate oryza sativa pseudo-response regulator 37 (OsPRR37) in photoperiodic flowering in rice. [PDF]
Mol Cells, 2015 This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/.Flowering time (or ...
Kwon CT, Koo BH, Kim D, Yoo SC, Paek NC.
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Crystal structures of two aminoglycoside kinases bound with a eukaryotic protein kinase inhibitor. [PDF]
PLoS ONE, 2011 Antibiotic resistance is recognized as a growing healthcare problem. To address this issue, one strategy is to thwart the causal mechanism using an adjuvant in partner with the antibiotic.
Desiree H Fong +3 more
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eLife, 2020 Casein kinases are a large family of intracellular serine/threonine kinases that control a variety of cellular signaling functions. Here we report that a member of casein kinase 1 family, casein kinase 1G2, CSNK1G2, binds and inhibits the activation of ...
Dianrong Li +9 more
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Casein Kinase 1 and Human Disease: Insights From the Circadian Phosphoswitch
Frontiers in Molecular Biosciences, 2022 Biological systems operate in constant communication through shared components and feedback from changes in the environment. Casein kinase 1 (CK1) is a family of protein kinases that functions in diverse biological pathways and its regulation is ...
Joel C. Francisco +2 more
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Using bacteria to determine protein kinase specificity and predict target substrates. [PDF]
PLoS ONE, 2012 The identification of protein kinase targets remains a significant bottleneck for our understanding of signal transduction in normal and diseased cellular states.
Michael F Chou +5 more
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Phosphorylation and regulation of group II metabotropic glutamate receptors (mGlu2/3) in neurons
Frontiers in Cell and Developmental Biology, 2022 Group II metabotropic glutamate (mGlu) receptors (mGlu2/3) are Gαi/o-coupled receptors and are primarily located on presynaptic axonal terminals in the central nervous system.
Li-Min Mao +6 more
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iScience, 2022 Summary: Candida albicans is a leading cause of death due to systemic fungal infections. Poor patient outcomes are attributable to the limited number of antifungal classes and the increasing prevalence of drug resistance.
Yunjin Lee +4 more
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