Results 51 to 60 of about 24,797 (285)

Histone H3K18 Lactylation Promotes the Malignant Progression of Wilms Tumor via a PSRC1/AKT/HIF‐1α Positive Feedback Loop

Advanced Science, EarlyView.
In nephroblastoma, aberrant glycolysis drives lactate accumulation, which elevates histone H3K18 lactylation via p300. Lactylation of the PSRC1 promoter activates its transcription. PSRC1 competitively binds AKT, relieving PTEN‐mediated inhibition and triggering AKT/mTOR/HIF‐1α signaling.
Yanping Wang, Hongjie Gao, Bifei Zhang, Xuetian Li, Ding Li, Aihua Cao, Fengyin Sun   +6 more
wiley   +1 more source

Roscovitine-Derived, Dual-Specificity Inhibitors of Cyclin-Dependent Kinases and Casein Kinases 1

, 2016
Cyclin-dependent kinases (CDKs) and casein kinases 1 (CK1) are involved in the two key molecular features of Alzheimer’s disease, production of amyloid-β peptides (extracellular plaques) and hyper-phosphorylation of Tau (intracellular neurofibrillary ...
Yoan Ferandin (1291758), Angela Lopez-Giral (2419555), Emmanuel Mikros (148999), Marc Flajolet (364288), Paul Greengard (199705), Laurent Meijer (243859), Hervé Galons (2374684), Nassima Oumata (446994), Vassilios Myrianthopoulos (148997), Marie-Lorène Goddard (2419561), Luc Demange (2419558), Karima Bettayeb (2392852)   +11 more
core   +1 more source

Nuclear factor of activated T cells as a driver of tumor progression and a target for precision therapy

Animal Models and Experimental Medicine, EarlyView.
Overview illustration of dysregulated NFAT activation coordinating upstream signaling, post‐translational regulation and cancer promoting pathways to induce abnormal gene expression that drives tumor development, progression and immune escape. Abstract The Nuclear Factor of Activated T Cells (NFAT) family comprises closely related transcription factors.
Hira Khan, Khushbakhat Alia, Yusra Al Dhaheri, Muhammad Naseem, Rabah Iratni, Edgar Serfling, Khalid Muhammad   +6 more
wiley   +1 more source

The Yeast Glucose Sensing Receptor is Stabilized by Interaction with Casein Kinases

, 2022
Many metabolic diseases are rooted in the inability to process glucose or regulate its uptake. These processes can be explored using yeast as a model.
Mohler, Emma E
core   +1 more source

Glycogen Synthase Kinase (GSK) 3β phosphorylates and protects nuclear myosin 1c from proteasome-mediated degradation to activate rDNA transcription in early G1 cells [PDF]

, 2014
Nuclear myosin 1c (NM1) mediates RNA polymerase I (pol I) transcription activation and cell cycle progression by facilitating PCAF-mediated H3K9 acetylation, but the molecular mechanism by which NM1 is regulated remains unclear.
Laura Borgonovo-Brandter (573527), Neus Visa (245920), Gothenburg University., Al-Muzzaini, Bader, Anne Von Euler, Von Euler Anne, Sarshad, Aishe A., Visa, Neus,, Laura Borgonovo-Brandter, Martin Corcoran (573526), Borgonovo-Brandter Laura, Martin Corcoran, Piergiorgio Percipalle (393101), Borgonovo-Brandter, Laura, Visa, Neus, Göteborgs universitet., Lamont, Douglas, Sarshad, Aishe A.,, Corcoran, Martin, Percipalle Piergiorgio, Von Euler, Anne, Percipalle, Piergiorgio, Al-Muzzaini Bader, Corcoran Martin, Visa Neus, Douglas Lamont (573529), Lamont Douglas, Aishe A Sarshad, Bader Al-Muzzaini, Anne Von Euler (573528), Sarshad Aishe A., Von Euler, Anne,, Bader Al-Muzzaini (393098), Douglas Lamont, Aishe A. Sarshad (573525), Neus Visa, Piergiorgio Percipalle   +36 more
core   +1 more source

A Sequentially Priming Phosphorylation Cascade Activates the Gliomagenic Transcription Factor Olig2

Cell Reports, 2017
During development of the vertebrate CNS, the basic helix-loop-helix (bHLH) transcription factor Olig2 sustains replication competence of progenitor cells that give rise to neurons and oligodendrocytes.
Jing Zhou, An-Chi Tien, John A. Alberta, Scott B. Ficarro, Amelie Griveau, Yu Sun, Janhavee S. Deshpande, Joseph D. Card, Meghan Morgan-Smith, Wojciech Michowski, Rintaro Hashizume, C. David James, Keith L. Ligon, William D. Snider, Peter Sicinski, Jarrod A. Marto, David H. Rowitch, Charles D. Stiles   +17 more
doaj   +1 more source

Protective Effect of Phytic Acid in Cardiovascular Diseases: A Systematic Review

ChemFoodChem, EarlyView.
ABSTRACT Cardiovascular diseases (CVDs) are a cluster of ailments that impact the heart and blood vessels and are a primary public health problem of mortality on a global scale. Phytic acid, a dietary constituent frequently present in foods like seeds, has been linked to many pharmacological attributes, including anti‐cancer, antioxidant, anti ...
Marta M. S. de Freitas Almeida, Éverton A. Pereira, Patricia Severino, Cristina Blanco‐Llamero, Sandra L. Santos, Luciana N. Andrade, Ricardo G. Amaral, Eliana B. Souto   +7 more
wiley   +1 more source

Nicotinamide Promotes Cell Survival and Differentiation as Kinase Inhibitor in Human Pluripotent Stem Cells

Stem Cell Reports, 2018
Summary: Nicotinamide, the amide form of vitamin B3, is widely used in disease treatments and stem cell applications. However, nicotinamide's impact often cannot be attributed to its nutritional functions.
Ya Meng, Zhili Ren, Faxiang Xu, Xiaoxiao Zhou, Chengcheng Song, Vivien Ya-Fan Wang, Weiwei Liu, Ligong Lu, James A. Thomson, Guokai Chen   +9 more
doaj   +1 more source

GPR68 Contributes to Persistent Acidosis-Induced Activation of AGC Kinases and Tyrosine Phosphorylation in Organotypic Hippocampal Slices

Frontiers in Neuroscience, 2021
Persistent acidosis occurs in ischemia and multiple neurological diseases. In previous studies, acidic stimulation leads to rapid increase in intracellular calcium in neurons.
Guokun Zhou, Xiang-ming Zha
doaj   +1 more source

Crystal structure of the Golgi casein kinase [PDF]

Proceedings of the National Academy of Sciences, 2013
The family with sequence similarity 20 (Fam20) kinases phosphorylate extracellular substrates and play important roles in biomineralization. Fam20C is the Golgi casein kinase that phosphorylates secretory pathway proteins within Ser-x-Glu/pSer motifs. Mutations in Fam20C cause Raine syndrome, an osteosclerotic bone dysplasia.
Junyu, Xiao, Vincent S, Tagliabracci, Jianzhong, Wen, Soo-A, Kim, Jack E, Dixon   +4 more
openaire   +2 more sources