Results 71 to 80 of about 24,797 (285)
Structural Insights Into the Function of Leishmania major Adenylosuccinate Lyase
Proteins: Structure, Function, and Bioinformatics, EarlyView.ABSTRACT One of several intriguing aspects of kinetoplastid biochemistry is the complete dependence on host purines and purine recycling due to the lack of a de novo purine biosynthesis pathway. Adenylosuccinate lyase (ASL, EC 4.3.2.2) is a key enzyme in the purine synthesis pathway responsible for the conversion of adenylosuccinate into adenosine ...
Ivan R. e Silva +10 more
wiley +1 more source
Exploring the CK2 Paradox: Restless, Dangerous, Dispensable
Pharmaceuticals, 2017 The history of protein kinase CK2 is crowded with paradoxes and unanticipated findings. Named after a protein (casein) that is not among its physiological substrates, CK2 remained in search of its targets for more than two decades after its discovery in ...
Cinzia Franchin +6 more
doaj +1 more source
Responsive Materials, EarlyView.This review summarizes the recent progress in responsive NO‐releasing materials and their applications in biofilm‐associated infectious diseases. The design principles and response mechanisms are given to provide inspiration toward the future development of multi‐responsive NO‐releasing materials.
Wenyue Sun +8 more
wiley +1 more source
Molecular simulations of enzymatic phosphorylation of disordered proteins and their condensates
Nature CommunicationsCondensation and aggregation of disordered proteins in cellular non-equilibrium environments are shaped decisively by enzymes. Enzymes called kinases phosphorylate proteins, consuming the chemical fuel ATP.
Emanuele Zippo +3 more
doaj +1 more source
Marine Drugs, 2018 Alzheimer’s disease (AD) is becoming one of the most disturbing health and socioeconomic problems nowadays, as it is a neurodegenerative pathology with no treatment, which is expected to grow further due to population ageing.
Laura Llorach-Pares +3 more
doaj +1 more source
Casein Kinase 1: A Wnt'er of Disconnect [PDF]
Current Biology, 2002 Phosphorylation of beta-catenin, a central downstream component of the Wnt pathway, by glycogen synthase kinase 3 is essential for its targeted degradation by the proteosome. New studies show that casein kinase 1 primes beta-catenin for subsequent phophorylation by glycogen synthase kinase 3.
openaire +2 more sources
Prothymosin α is phosphorylated by casein kinase‐2 [PDF]
FEBS Letters, 1992 Prothymosin α (ProTα) is a 12.5 kDa acidic polypeptide that is considered to have a nuclear function related to cell proliferation. Inspection of its amino acid sequence revealed the presence of sequences that may serve as targets for phosphorylation by casein kinase‐2 (CK‐2). ProTα isolated from calf thymocytes was phosphorylated in vitro by CK‐2. The
Barcia, Miguel G. +4 more
openaire +2 more sources
DNA‐Enzyme Hybrid Nanostructures: Functional Materials to Modulate Enzymatic Activity
Small, EarlyView.DNA–enzyme hybrid nanostructures enable precise spatial and stoichiometric control over enzyme organization, offering a powerful platform to modulate catalytic activity. This review critically evaluates key mechanistic hypotheses, including proximity effects, microenvironment changes, confinement, and stabilization, as well as highlighting ...
Manar Elnaggar, Amelie Heuer‐Jungemann
wiley +1 more source
Journal of Animal Ecology, EarlyView.Replicated mainland–islet populations of the Skyros wall lizard reveal consistent divergence in digestive physiology, including gut morphology, passage time, digestive efficiency and enzyme activity. These results show how ecological variation in resource availability can shape digestive performance across populations in insular environments.
Aikaterini Reppa +8 more
wiley +1 more source
Casein kinase 1 proteomics reveal prohibitin 2 function in molecular clock.
PLoS ONE, 2012 Throughout the day, clock proteins synchronize changes in animal physiology (e.g., wakefulness and appetite) with external cues (e.g., daylight and food).
Lorna S Kategaya +5 more
doaj +1 more source