Results 11 to 20 of about 341,145 (337)

Molecular basis of caspase-1 polymerization and its inhibition by a new capping mechanism [PDF]

, 2015
Inflammasomes are cytosolic caspase-1-activation complexes that sense intrinsic and extrinsic danger signals, and trigger inflammatory responses and pyroptotic cell death. Homotypic interactions among Pyrin domains and caspase recruitment domains (CARDs)
A Dorfleutner, A Druilhe, A Lu, A Lu, A Vezzani, Alexander B Tong, Alvin Lu, B Wu, C Stehlik, CP Guimaraes, E de Alba, E Latz, EF Pettersen, EH Egelman, EM Kofoed, EW Humke, F Bedoya, F DiMaio, F Hou, F Martinon, Florian I Schmidt, G López-Castejón, GG Brusselle, GR Robbins, H Hirakawa, H Wu, Hao Wu, HH Park, Hidde L Ploegh, HT Le, JA Cooper, JA Mindell, JE Caldwell, JP da Cunha, K Kersse, KL Meerbrey, KL Tsao, L Holm, L Zhang, M Aguilera, M Biasini, M Lamkanfi, M Lamkanfi, MD Winn, MF Carlier, N Esser, NA Maun, P Emsley, PD Adams, PM Ridker, Q Qiao, Qian Yin, R Ferrao, SC Lin, SH Lee, SH Scheres, Shuobing Chen, T Wakatsuki, Tian-Min Fu, TR Shaikh, X Cai, Y Qu, Yang Li, YH Lin, Youdong Mao, Z Hu   +65 more
core   +6 more sources

RAB39a binds caspase-1 and is required for caspase-1-dependent interleukin-1β secretion. [PDF]

Journal of Biological Chemistry, 2009
Interleukin-1beta (IL-1beta) is an important pro-inflammatory cytokine that is secreted by unconventional means in a caspase-1-dependent manner. Using a one-step immunoprecipitation approach to isolate endogenous caspase-1 from the monocytic THP1 cell line, we identified previously undescribed binding partners using mass spectrometry.
Christine Becker, Emma M. Creagh, Luke A. J. O'Neill   +2 more
openaire   +5 more sources

GSDMD-mediated pyroptosis restrains intracellular Chlamydia trachomatis growth in macrophages

Frontiers in Cellular and Infection Microbiology, 2023
Pyroptosis, a type of programmed necrosis associated with inflammatory, is a host defense mechanism against microbial infections. Although Chlamydia has been shown to induce pyroptosis, whether pyroptosis directly impacts the growth of Chlamydia has not ...
Ping Jiang, Hongzhi Chen, Xiaojing Feng, Huiqi Xie, Mengjie Jiang, Danning Xu, Haoneng Tang, Ningjie Zhang, Jianlin Chen, Lei Zhang, Lingli Tang   +10 more
doaj   +1 more source

YopM Puts Caspase-1 on Ice [PDF]

Cell Host & Microbe, 2012
Caspase-1-mediated detection of pathogens is a potent arm of the innate immune system. LaRock and Cookson (2012) show that the Yersinia type III secretion effector, YopM, directly inhibits caspase-1.
Edward A. Miao, Ine Jorgensen
openaire   +3 more sources

Pyroptosis: A Common Feature of Immune Cells of Haemodialysis Patients

Toxins, 2021
NLRP-3 inflammasome activation can result in interleukin-1β (IL-1β) release and inflammatory cell death (pyroptosis). Caspase-1 is able to trigger both processes.
Christof Ulrich, Leonie Kneser, Roman Fiedler, Julia Beckert, Susann Wildgrube, Eric Seibert, Sylvia Fick, Christoph Schäfer, Silke Markau, Bogusz Trojanowicz, Matthias Girndt   +10 more
doaj   +1 more source

Caspase-8 Potentiates Triglyceride (TG)-Induced Cell Death of THP-1 Macrophages via a Positive Feedback Loop

Korean Journal of Clinical Laboratory Science, 2021
Hypertriglyceridemia is the main risk factor for atherosclerosis. It is reported that triglyceride (TG) induces macrophage cell death, and is involved in the formation of plaques and development of atherosclerosis.
Byung Chul Jung, Jaewon Lim, Sung Hoon Kim, Yoon Suk Kim   +3 more
doaj   +1 more source

Thalidomide Inhibits Activation of Caspase-1 [PDF]

The Journal of Immunology, 2009
Abstract Thalidomide is an efficient anti-inflammatory and anti-angiogenic drug, but its therapeutic use is problematic due to a strong teratogenic activity. Nevertheless, thalidomide was approved for the treatment of inflammatory skin diseases and certain types of cancer, and it is extensively tested for several other indications ...
Keller, Martin, Sollberger, Gabriel, Beer, Hans Dietmar   +2 more
openaire   +4 more sources

Caspase-1 as a regulatory molecule of lipid metabolism [PDF]

Lipids in Health and Disease, 2020
AbstractCaspase-1 is an evolutionarily conserved inflammatory mediated enzyme that cleaves and activates inflammatory cytokines. It can be activated through the assembly of inflammasome and its major effect is to activate the pro-inflammatory cytokines; interleukin 1β (IL-1β) and interluekine-18 (IL-18).
Tesfahun Dessale Admasu, Zeleke Geto, Birhanu Ayelign, Gashaw Dessie, Meseret Derbew Molla   +4 more
openaire   +3 more sources

A Role for Caspase-1 in Heart Failure [PDF]

Circulation Research, 2007
Apoptosis of cardiomyocytes is increased in heart failure and has been implicated in disease progression. The activation of “proapoptotic” caspases represents a key step in cardiomyocyte apoptosis. In contrast, the role of “proinflammatory” caspases (caspases 1, 4, 5, 11, 12) is unclear. Here, we study the cardiac function of caspase-1.
Sabine Merkle, Robert J.A. Frost, Stefan Frantz, Martin J. Lohse, Johann Bauersachs, Eva M. Schmitteckert, Stefan Engelhardt, Monika Buitrago, Michael P. Schön   +8 more
openaire   +3 more sources

An Apoptotic Caspase Network Safeguards Cell Death Induction in Pyroptotic Macrophages

Cell Reports, 2020
Summary: Pyroptosis has emerged as a key mechanism by which inflammasomes promote host defense against microbial pathogens and sterile inflammation. Gasdermin D (GSDMD)-mediated cell lysis is a hallmark of pyroptosis, but our understanding of cell death ...
Nathalia Moraes de Vasconcelos, Nina Van Opdenbosch, Hanne Van Gorp, Rosa Martín-Pérez, Annalisa Zecchin, Peter Vandenabeele, Mohamed Lamkanfi   +6 more
doaj   +1 more source