Results 21 to 30 of about 329,630 (269)
YopM Puts Caspase-1 on Ice [PDF]
Cell Host & Microbe, 2012 Caspase-1-mediated detection of pathogens is a potent arm of the innate immune system. LaRock and Cookson (2012) show that the Yersinia type III secretion effector, YopM, directly inhibits caspase-1.
Jørgensen, Ine, Miao, Edward A.
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Caspase‐1‐induced pyroptotic cell death [PDF]
Immunological Reviews, 2011 Summary: Programmed cell death is a necessary part of development and tissue homeostasis enabling the removal of unwanted cells. In the setting of infectious disease, cells that have been commandeered by microbial pathogens become detrimental to the host. When macrophages and dendritic cells are compromised in this way, they can be lysed by pyroptosis,
Edward A, Miao +2 more
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Caspase‐1 is not involved in experimental hepatitis in mouse [PDF]
FEBS Letters, 1999 Experimental hepatitis induced by tumor necrosis factor in d‐(+)‐galactosamine‐sensitized mice or by an agonistic anti‐Fas antibody in normal mice is accompanied by dramatic apoptosis of hepatocytes. Apoptosis is the final result of activation of a cascade of caspases.
van Molle, Wim +2 more
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Caspase-1 as a regulatory molecule of lipid metabolism [PDF]
Lipids in Health and Disease, 2020 AbstractCaspase-1 is an evolutionarily conserved inflammatory mediated enzyme that cleaves and activates inflammatory cytokines. It can be activated through the assembly of inflammasome and its major effect is to activate the pro-inflammatory cytokines; interleukin 1β (IL-1β) and interluekine-18 (IL-18).
Meseret Derbew Molla +4 more
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Regulation and Function of the Caspase-1 in an Inflammatory Microenvironment [PDF]
Journal of Investigative Dermatology, 2015 The inflammasome is a complex of proteins that has a critical role in mounting an inflammatory response in reply to a harmful stimulus that compromises the homeostatic state of the tissue. The NLRP3 inflammasome, which is found in a wound-like environment, is comprised of three components: the NLRP3, the adaptor protein ASC and caspase-1. Interestingly,
Lee, Dai-Jen +7 more
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iScience, 2023 Summary: Canonical pyroptosis is type of programmed cell death depending on active caspase-1, and the inflammasome carries out caspase-1 activation. Here, we showed that docosahexaenoic acid (DHA) induced ovarian cancer cell deaths in caspase-1-dependent
Ozlem Calbay +9 more
doaj +1 more source
Apoptosis in prostate carcinoma tissue: The role of caspase-3, caspase-1, and alkaline DNase activity [PDF]
Journal of Medical BiochemistryBackground: Prostate glandular tissue maintains a delicate balance between cellular proliferation and programmed cell death (apoptosis), ensuring the preservation of normal glandular architecture in healthy individuals.
Veljkovic Andrej +6 more
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Cell Reports, 2017 Inflammasomes activate the protease caspase-1, which cleaves interleukin-1β and interleukin-18 to generate the mature cytokines and controls their secretion and a form of inflammatory cell death called pyroptosis.
Katharina S. Schneider +16 more
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Oligomerized CARD16 promotes caspase‐1 assembly and IL‐1β processing
FEBS Open Bio, 2015 Increasing evidence indicates that caspase recruitment domain (CARD)‐mediated caspase‐1 (CASP1) assembly is an essential process for its activation and subsequent interleukin (IL)‐1β release, leading to the initiation of inflammation.
Tadayoshi Karasawa +10 more
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Alpha 1-antitrypsin does not inhibit human monocyte caspase-1. [PDF]
PLoS ONE, 2015 BACKGROUND:Alpha 1-antitrypsin (A1AT) is a 52 kDa serine protease inhibitor produced largely by hepatocytes but also by mononuclear phagocytes. A1AT chiefly inhibits neutrophil elastase and proteinase-3 but has also been reported to have immune ...
Mohd Akhlakur Rahman +3 more
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