Results 31 to 40 of about 21,606,107 (313)

Regulation of caspase-3 processing by cIAP2 controls the switch between pro-inflammatory activation and cell death in microglia. [PDF]

, 2014
The activation of microglia, resident immune cells of the central nervous system, and inflammation-mediated neurotoxicity are typical features of neurodegenerative diseases, for example, Alzheimer's and Parkinson's diseases. An unexpected role of caspase-
Rodhe, J, Venero, JL, Rodhe, J,, Rodhe, Johanna, Joseph, B, Burguillos García, Miguel Ángel, Venero Recio, José Luis, Kavanagh, E, Burguillos, MA, Kavanagh, Edel T., Joseph, Bertrand, Joseph, B,   +11 more
core   +1 more source

Regulation and Function of the Caspase-1 in an Inflammatory Microenvironment [PDF]

Journal of Investigative Dermatology, 2015
The inflammasome is a complex of proteins that has a critical role in mounting an inflammatory response in reply to a harmful stimulus that compromises the homeostatic state of the tissue. The NLRP3 inflammasome, which is found in a wound-like environment, is comprised of three components: the NLRP3, the adaptor protein ASC and caspase-1. Interestingly,
Lee, Dai-Jen, Du, Fei, Chen, Shih-Wei, Nakasaki, Manando, Rana, Isha, Shih, Vincent FS, Hoffmann, Alexander, Jamora, Colin   +7 more
openaire   +4 more sources

ASC/inflammasome-independent pyroptosis in ovarian cancer cells through translational augmentation of caspase-1

iScience, 2023
Summary: Canonical pyroptosis is type of programmed cell death depending on active caspase-1, and the inflammasome carries out caspase-1 activation. Here, we showed that docosahexaenoic acid (DHA) induced ovarian cancer cell deaths in caspase-1-dependent
Ozlem Calbay, Ravi Padia, Mahmuda Akter, Lei Sun, Bin Li, Nicole Qian, Jianhui Guo, Zheng Fu, Lingtao Jin, Shuang Huang   +9 more
doaj   +1 more source

Caspase-1 activation during Eh-macrophage contact degrades cullin-1/5.

, 2021
(A, B) THP-1 derived macrophages were pre-incubated with the pan-caspase inhibitor Z-VAD-fmk (100μM) and caspase-1 specific inhibitor Z-YVAD-fmk (100μM) for 1 h followed by stimulation with Eh (10:1 ratio) for 10 min.
Kris Chadee (249039), Antoine Dufour (628454), Attinder Chadha (11414273), France Moreau (458493), Shanshan Wang (283009)   +4 more
core   +1 more source

Apoptosis in prostate carcinoma tissue: The role of caspase-3, caspase-1, and alkaline DNase activity [PDF]

Journal of Medical Biochemistry
Background: Prostate glandular tissue maintains a delicate balance between cellular proliferation and programmed cell death (apoptosis), ensuring the preservation of normal glandular architecture in healthy individuals.
Veljkovic Andrej, Hadzi-Djokic Jovan, Kocic Gordana, Li Xiaobo, Roumeliotis Stefanos, Sokolović Dušan, Klisic Aleksandra   +6 more
doaj   +1 more source

Uterine Endoplasmic Reticulum Stress and Its Unfolded Protein Response May Regulate Caspase 3 Activation in the Pregnant Mouse Uterus [PDF]

, 2013
We have previously proposed that uterine caspase-3 may modulate uterine contractility in a gestationally regulated fashion. The objective of this study was to determine the mechanism by which uterine caspase-3 is activated and consequently controlled in ...
Subedi, Kalpana, Jennifer C. Condon, Chandrashekara Kyathanahalli, Kalpana Subedi, Lydon, John P., Arvind Suresh, Kyathanahalli, Chandrashekara, Condon, Jennifer C., Jeyasuria, Pancharatnam, Pancharatnam Jeyasuria, Rashekara Kyathanahalli, Jennifer C Condon, Suresh, Arvind   +12 more
core   +1 more source

Caspase-3 content in SNU-1 cells.

, 2021
Increase in intracellular Caspase-3 compared to blank (untreated) SNU-1 cells upon treatment with 50–5000 nm sized aminated, carboxylated and NF particles for 4 h. Data compared with respect to surface functionalization (A) or particle size (B). All data
Amrita Banerjee (382658), Weilin L. Shelver (189419), Lloyd O. Billey (2454244)   +2 more
core   +1 more source

Caspase-1 inhibition by YVAD generates tregs pivoting IL-17 to IL-22 response in β-glucan induced airway inflammation

, 2022
During Aspergillus fumigatus mediated lung inflammation, NLRP3 inflammasome is rapidly activated that aggravates IL-1β production contributing to lung inflammation.
Parameswar Dalai (12159242), Divyesh Patel (5476793), Shivani Yadav (12159236), Dipeeka Mandaliya (12159233), Hima Vora (12159245), Omkar Naik (12159239), Dhruvi Shah (4951405), Naveen Challagundla (12159230), Reena Agrawal-Rajput (4951399)   +8 more
core   +1 more source

Activation of Caspase-1 in the Nucleus Requires Nuclear Translocation of Pro-caspase-1 Mediated by Its Prodomain [PDF]

Journal of Biological Chemistry, 1998
The interleukin-1beta-converting enzyme-like protease precursor, pro-caspase-1, has an N-terminal prodomain that is removed during cleavage activation of the protease. Here we show that tumor necrosis factor treatment of HeLa cells induced apoptosis without detectable proteolytic activation of caspase-1 in the cytosol.
Mao, P.-L., Jiang, Y., Wee, B.Y., Porter, A.G.   +3 more
openaire   +2 more sources

The Inflammasome Drives GSDMD-Independent Secondary Pyroptosis and IL-1 Release in the Absence of Caspase-1 Protease Activity

Cell Reports, 2017
Inflammasomes activate the protease caspase-1, which cleaves interleukin-1β and interleukin-18 to generate the mature cytokines and controls their secretion and a form of inflammatory cell death called pyroptosis.
Katharina S. Schneider, Christina J. Groß, Roland F. Dreier, Benedikt S. Saller, Ritu Mishra, Oliver Gorka, Rosalie Heilig, Etienne Meunier, Mathias S. Dick, Tamara Ćiković, Jan Sodenkamp, Guillaume Médard, Ronald Naumann, Jürgen Ruland, Bernhard Kuster, Petr Broz, Olaf Groß   +16 more
doaj   +1 more source