Results 31 to 40 of about 360,151 (357)

YopM Puts Caspase-1 on Ice [PDF]

Cell Host & Microbe, 2012
Caspase-1-mediated detection of pathogens is a potent arm of the innate immune system. LaRock and Cookson (2012) show that the Yersinia type III secretion effector, YopM, directly inhibits caspase-1.
Jørgensen, Ine, Miao, Edward A.
openaire   +2 more sources

Defusing inflammasomes. [PDF]

, 2018
In this issue of JEM, Boucher et al. (https://doi.org/10.1084/jem.20172222) report isolation of active caspase-1 from macrophages after inflammasome activation.
Sandstrom, Andrew, VANCE, Russell E.
core   +1 more source

Caspase-1: The inflammasome and beyond [PDF]

Innate Immunity, 2013
Caspase-1 plays a fundamental role in innate immunity and in several important inflammatory diseases as the protease activates the pro-inflammatory cytokines proIL-1β and proIL-18. Caspase-1 itself is activated in different inflammasome complexes, which assemble in response to a variety of exogenous and endogenous stressors. More recently, pyroptosis,
Sollberger, Gabriel, Strittmatter, Gerhard E, Garstkiewicz, Martha, Sand, Jennifer, Beer, Hans-Dietmar   +4 more
openaire   +3 more sources

Probiotics Improve Cognitive Impairment by Decreasing Bacteria-Related Pattern Recognition Receptor-Mediated Inflammation in the Gut-Brain Axis of Mice

Journal of Integrative Neuroscience, 2023
Introduction: Some studies have found that probiotics can improve cognitive impairment in Alzheimer’s disease, although the specific molecular mechanism by which this occurs has not been reported.
Xue-Qin Yang, Yang Zhao, Li Xue, Hui-Shan Wang, Jia Zeng, Jun-Rong Du, Zhe Xu   +6 more
doaj   +1 more source

Non-classical ProIL-1beta activation during mammary gland infection is pathogen-dependent but caspase-1 independent [PDF]

, 2014
Infection of the mammary gland with live bacteria elicits a pathogen-specific host inflammatory response. To study these host-pathogen interactions wild type mice, NF-kappaB reporter mice as well as caspase-1 and IL-1beta knockout mice were ...
A Ito, B Brand, C Coeshott, C Kebaier, C Riollet, D Demon, D Demon, Dario S. Zamboni, DD Bannerman, Dieter Demon, DJ Hazuda, E Brouillette, E Gonen, EM Ibeagha-Awemu, Evelyne Meyer, F Li, H Carlsen, Harald Carlsen, HW Barkema, J Gunther, J Mehrzad, J Monks, K Demeyere, K Farhat, K Jensen, K Persson-Waller, Koen Breyne, Kristel Demeyere, KW Kim, L Connelly, L Lara-Zárate, M Lamkanfi, M Rinaldi, M Wittmann, MG Stevens, Niek N. Sanders, OC Kousidou, Peter Vandenabeele, RA Black, S Balasubramanian, S Bougarn, S Elazar, S Elazar, S Liu, S Mandard, S Notebaert, S Notebaert, S Notebaert, SK Cool, Steven K. Cool, TC Lin, Tom Vandenberghe, U Meyer-Hoffert, U Schonbeck, W Yang, Wim Van Den Broeck, X Li, YH Schukken   +57 more
core   +5 more sources

Molecular basis of caspase-1 polymerization and its inhibition by a new capping mechanism [PDF]

, 2015
Inflammasomes are cytosolic caspase-1-activation complexes that sense intrinsic and extrinsic danger signals, and trigger inflammatory responses and pyroptotic cell death. Homotypic interactions among Pyrin domains and caspase recruitment domains (CARDs)
A Dorfleutner, A Druilhe, A Lu, A Lu, A Vezzani, Alexander B Tong, Alvin Lu, B Wu, C Stehlik, CP Guimaraes, E de Alba, E Latz, EF Pettersen, EH Egelman, EM Kofoed, EW Humke, F Bedoya, F DiMaio, F Hou, F Martinon, Florian I Schmidt, G López-Castejón, GG Brusselle, GR Robbins, H Hirakawa, H Wu, Hao Wu, HH Park, Hidde L Ploegh, HT Le, JA Cooper, JA Mindell, JE Caldwell, JP da Cunha, K Kersse, KL Meerbrey, KL Tsao, L Holm, L Zhang, M Aguilera, M Biasini, M Lamkanfi, M Lamkanfi, MD Winn, MF Carlier, N Esser, NA Maun, P Emsley, PD Adams, PM Ridker, Q Qiao, Qian Yin, R Ferrao, SC Lin, SH Lee, SH Scheres, Shuobing Chen, T Wakatsuki, Tian-Min Fu, TR Shaikh, X Cai, Y Qu, Yang Li, YH Lin, Youdong Mao, Z Hu   +65 more
core   +2 more sources

IL-1R and inflammasomes mediate early pulmonary protective mechanisms in respiratory brucella abortus infection [PDF]

, 2016
Brucella spp. infection is frequently acquired through contaminated aerosols. The role of interleukin-1 beta (IL-1β) in the early pulmonary response to respiratory Brucella infection is unknown.
Alonso Paiva, Iván Mathias, Baldi, Pablo Cesar, Campos, Priscila C., Falivene, Juliana, Fernandez, Andrea Giselle, Ferrero, Mariana Cristina, Hielpos, María Soledad, Muñoz González, Florencia, Oliveira, Sergio Costa, Vieira, Angelica T.   +9 more
core   +1 more source

Lysophosphatidylcholine activates caspase-1 in microglia via a novel pathway involving two inflammasomes. [PDF]

, 2017
Inflammasomes regulate microglial caspase-1 activation and subsequent neuroinflammatory processes in brain pathology. In the present study, we have identified inflammasomes causing caspase-1 activation following stimulation of microglia with ...
Eder, C, Scholz, H
core   +1 more source

Nedd8 Regulates Inflammasome-Dependent Caspase-1 Activation [PDF]

Molecular and Cellular Biology, 2015
Caspase-1 is activated by the inflammasome complex to process cytokines like interleukin-1β (IL-1β). Pro-caspase-1 consists of three domains, CARD, p20, and p10. Association of pro-caspase-1 with the inflammasome results in initiation of its autocatalytic activity, culminating in self-cleavage that generates catalytically active subunits (p10 and p20).
Segovia, Jesus A, Tsai, Su-Yu, Chang, Te-Hung, Shil, Niraj K, Weintraub, Susan T, Short, John D, Bose, Santanu   +6 more
openaire   +3 more sources

ASC/inflammasome-independent pyroptosis in ovarian cancer cells through translational augmentation of caspase-1

iScience, 2023
Summary: Canonical pyroptosis is type of programmed cell death depending on active caspase-1, and the inflammasome carries out caspase-1 activation. Here, we showed that docosahexaenoic acid (DHA) induced ovarian cancer cell deaths in caspase-1-dependent
Ozlem Calbay, Ravi Padia, Mahmuda Akter, Lei Sun, Bin Li, Nicole Qian, Jianhui Guo, Zheng Fu, Lingtao Jin, Shuang Huang   +9 more
doaj   +1 more source