Results 41 to 50 of about 21,606,107 (313)
Alpha 1-antitrypsin does not inhibit human monocyte caspase-1. [PDF]
PLoS ONE, 2015 BACKGROUND:Alpha 1-antitrypsin (A1AT) is a 52 kDa serine protease inhibitor produced largely by hepatocytes but also by mononuclear phagocytes. A1AT chiefly inhibits neutrophil elastase and proteinase-3 but has also been reported to have immune ...
Mohd Akhlakur Rahman +3 more
doaj +1 more source
Compartmentalized megakaryocyte death generates functional platelets committed to caspase-independent death [PDF]
, 2003 Caspase-directed apoptosis usually fragments cells, releasing nonfunctional, prothrombogenic, membrane-bound apoptotic bodies marked for rapid engulfment by macrophages.
Jones, David B. +9 more
core +1 more source
, 2022 Western blot of pro- and cleaved caspase-3 [ratio to ß-actin]. Shown are representative blots separated by location of lung tissue sampling (contusion site, ipsilateral control, and contralateral control). Lung tissue samples were homogenized, separated,
Martin Sassen (14232410) +7 more
core +1 more source
Role of caspase-1 in regulation of triglyceride metabolism [PDF]
Proceedings of the National Academy of Sciences, 2013 Caspase-1 is a cysteine protease that can be activated by both endogenous and exogenous inflammatory stimuli and has been shown to have important functions in processes as diverse as proteolytic activation of cytokines, cell death, and membrane repair. Caspase-1–dependent production of the inflammatory cytokines IL-1 and IL-18 has also been implicated ...
Maya E, Kotas +6 more
openaire +2 more sources
Caspase-8 content in SNU-1 cells.
, 2021 Increases in intracellular Caspase-8 compared to blank (untreated) SNU-1 cells upon treatment with 50–5000 nm sized aminated, carboxylated and NF particles for 4 h. Data compared with respect to surface functionalization (A) or particle size (B).
Amrita Banerjee (382658) +2 more
core +1 more source
Role of Caspase 1 in Neurologic Disease [PDF]
Archives of Neurology, 2000 In recent years substantial advances have taken place in understanding the mechanistic pathways mediating neuronal cell death in a variety of neurologic diseases. Since the central nervous system (CNS) has little, if any, power of functional neuronal regeneration, prevention of neuronal cell death is an important target of modern neurotherapeutics.
openaire +2 more sources
Roles of caspase-1 in Listeria infection in mice [PDF]
International Immunology, 2004 Caspase-1 [IL-1beta-converting enzyme (ICE)] processes substrate precursor molecules to yield the biologically active form of IL-1beta and IL-18, both of which are considered to play important roles in the host defense by activation of both innate and adaptive immunity.
Noriko M, Tsuji +6 more
openaire +2 more sources
Role and Association of Inflammatory and Apoptotic Caspases in Renal Tubulointerstitial Fibrosis
Kidney & Blood Pressure Research, 2016 Background/Aims: Caspases, an evolutionary conserved family of aspartate-specific cystein proteases, play pivotal roles in apoptotic and inflammatory signaling.
You Ke +7 more
doaj +1 more source
Caspase-1 Inhibitor Reduces Pyroptosis Induced by Brain Death in Kidney
Frontiers in Surgery, 2021 Brain death (BD) induces an organ-level inflammatory response. However, the underlying mechanisms have not been fully elucidated. Here, we investigated the role of caspase-1-mediated pyroptosis in BD-induced kidney injury in rats.
Weifeng Liu +21 more
doaj +1 more source
Oligomerized CARD16 promotes caspase‐1 assembly and IL‐1β processing
FEBS Open Bio, 2015 Increasing evidence indicates that caspase recruitment domain (CARD)‐mediated caspase‐1 (CASP1) assembly is an essential process for its activation and subsequent interleukin (IL)‐1β release, leading to the initiation of inflammation.
Tadayoshi Karasawa +10 more
doaj +1 more source