Results 41 to 50 of about 360,151 (357)

ASC filament formation serves as a signal amplification mechanism for inflammasomes [PDF]

, 2016
A hallmark of inflammasome activation is the ASC speck, a micrometre-sized structure formed by the inflammasome adaptor protein ASC (apoptosis-associated speck-like protein containing a CARD), which consists of a pyrin domain (PYD) and a caspase ...
Broz, Petr, Dick, Mathias S., Hiller, Sebastian, Rühl, Sebastian, Sborgi, Lorenzo   +4 more
core   +1 more source

Caspase-1 inflammasomes in infection and inflammation [PDF]

Journal of Leukocyte Biology, 2007
AbstractNucleotide-binding and oligomerization domain-like receptors (NLRs) constitute a family of germline-encoded pattern-recognition receptors, which allow the host to respond rapidly to a wide variety of pathogenic microorganisms. Here, we discuss recent advances in the study of a subset of NLRs, which control the activation of caspase-1 through ...
Lamkanfi, Mohamed, Kanneganti, Thirumala‐devi, Franchi, Luigi, Núñez, Gabriel   +3 more
openaire   +4 more sources

The mitochondrial protease HtrA2 restricts the NLRP3 and AIM2 inflammasomes. [PDF]

, 2018
Activation of the inflammasome pathway is crucial for effective intracellular host defense. The mitochondrial network plays an important role in inflammasome regulation but the mechanisms linking mitochondrial homeostasis to attenuation of inflammasome ...
Alnemri, Emad S., Champagne, Claudia, Doiron, Karine, Douglas, Todd, Leiva-Torres, Gabriel André, Mayes, Lindsey, Rodrigue-Gervais, Ian Gaël, Saleh, Maya, Vanié, Paulin, Vidal, Silvia M.   +9 more
core   +4 more sources

Caspase-1 Modulates Incisional Sensitization and Inflammation [PDF]

Anesthesiology, 2010
Background Surgical injury induces production and release of inflammatory mediators in the vicinity of the wound. They in turn trigger nociceptive signaling to produce hyperalgesia and pain. Interleukin-1β plays a crucial role in this process.
De-Yong, Liang, XiangQi, Li, Wen-Wu, Li, Dennis, Fiorino, Yanli, Qiao, Peyman, Sahbaie, David C, Yeomans, J David, Clark   +7 more
openaire   +2 more sources

Apoptosis in prostate carcinoma tissue: The role of caspase-3, caspase-1, and alkaline DNase activity [PDF]

Journal of Medical Biochemistry
Background: Prostate glandular tissue maintains a delicate balance between cellular proliferation and programmed cell death (apoptosis), ensuring the preservation of normal glandular architecture in healthy individuals.
Veljkovic Andrej, Hadzi-Djokic Jovan, Kocic Gordana, Li Xiaobo, Roumeliotis Stefanos, Sokolović Dušan, Klisic Aleksandra   +6 more
doaj   +1 more source

Reactive oxygen species regulate caspase-11 expression and activation of the non-canonical NLRP3 inflammasome during enteric pathogen infection [PDF]

, 2014
Enteropathogenic and enterohemorrhagic bacterial infections in humans are a severe cause of morbidity and mortality. Although NOD-like receptors (NLRs) NOD2 and NLRP3 have important roles in the generation of protective immune responses to enteric ...
Anand, Paras K, Kanneganti, Thirumala-Devi, Lamkanfi, Mohamed, Liu, Zhiping, Lupfer, Christopher R, Stokes, Kate L, Vogel, Peter   +6 more
core   +3 more sources

Glyburide inhibits the Cryopyrin/Nalp3 inflammasome [PDF]

, 2009
Inflammasomes activate caspase-1 for processing and secretion of the cytokines interleukin-1 beta (IL-1 beta) and IL-18. Cryopyrin/NALP3/NLRP3 is an essential component of inflammasomes triggered by microbial ligands, danger-associated molecular patterns
Mohamed Lamkanfi, James L. Mueller, Alberto C. Vitari, Shahram Misaghi, Anna Fedorova, Kurt Deshayes, Wyne P. Lee, Hal M. Hoffman, Vishva M. Dixit, Aguilar-Bryan, Ashcroft, Boyden, Cassel, Clement, Dostert, Duncan, Halle, Hamon, Hoffman, Hornung, Kanneganti, Kanneganti, Laliberte, Lamkanfi, Lamkanfi, Locovei, Ma, Mariathasan, Mariathasan, Martinon, Marty, Meyer, Miki, Miki, Pelegrin, Pelegrin, Perregaux, Riddle, Rosengren, Schott, Solle, Stoller, Sutterwala, Yvan-Charvet   +43 more
core   +2 more sources

Cytoprotective Activated Protein C Averts Nlrp3 Inflammasome–Induced Ischemia-Reperfusion Injury Via Mtorc1 Inhibition [PDF]

, 2017
Cytoprotection by activated protein C (aPC) after ischemia-reperfusion injury (IRI) is associated with apoptosis inhibition. However, IRI is hallmarked by inflammation, and hence, cell-death forms disjunct from immunologically silent apoptosis are, in ...
Al-Dabet, Moh\u27d Mohanad, Bock, Fabian, Braun-Dullaeus, Ruediger C., Camerer, Eric, Dockendorff, Chris, Elwakiel, Ahmed, Esmon, Charles T., Gadi, Ihsan, Ghosh, Sanchita, Griffin, John H., Huber, Tobias B., Isermann, Berend, Kohli, Shrey, Manoharan, Jayakumar, Nazir, Sumra, Ranjan, Satish, Shahzad, Khurrum   +16 more
core   +2 more sources

Caspase-1 Mediates Resistance in Murine Melioidosis [PDF]

Infection and Immunity, 2009
ABSTRACT The gram-negative rod Burkholderia pseudomallei is the causative agent of melioidosis, a potentially fatal disease which is endemic in tropical and subtropical areas. The bacterium multiplies intracellularly within the cytosol, induces the formation of actin tails, and can spread directly from ...
Breitbach, K., Kohler, J., Eske, K., Wongprompitak, P., Steinmetz, I., Sun, G.W., Liu, Y., Gan, Y.-H., Tan, G.   +8 more
openaire   +2 more sources

Brainiac Caspases: Beyond the Wall of Apoptosis [PDF]

, 2019
For the last two decades, caspases, a family of cysteine-aspartic proteases, have evolved from being considered solely as regulators of apoptosis or inflammation to having a wider range of functions.
Alonso Bellido, Isabel María, Burguillos García, Miguel Ángel, Espinosa Oliva, Ana María, García Revilla, Juan   +3 more
core   +1 more source